RESUMO
The paper outlines a new mode of intravascular anabolic steroidal transport. The single intravenous administration of metandrostenolone aqueous solution to rats increases hypertrophy rate of MM. plantaris. It was shown that the action of a single dose (0.05 mg/kg) exceeded that of metandrostenolone oil solution in a dose of 5 mg/kg. The multiple reduction of doses of the anabolic drug and the high level of bioavailability were achieved. This effect was explained by the application of the specific transport agent.
Assuntos
Sangue/efeitos dos fármacos , Metandrostenolona/farmacologia , Músculos/efeitos dos fármacos , Músculos/patologia , Animais , Sangue/metabolismo , Relação Dose-Resposta a Droga , Hipertrofia/sangue , Hipertrofia/etiologia , Masculino , Metandrostenolona/administração & dosagem , Metandrostenolona/sangue , Ratos , Ratos Wistar , Solubilidade , Fatores de TempoRESUMO
A single intravenous injection of solubilized alpha-tocopherol acetate to Wistar male rats in doses of 25, 50 and 100 mg/kg noticeably increased the animals' working capacity. The stimulation effect appeared 18 hours after the injection and was observable for two weeks. Utilization of glucose reserves in bioenergy supply of muscle activity has been shown. The maintenance of the action for such a long time may be accounted for by high metabolic stability of solubilized alpha-tocopherol acetate.