RESUMO
A new bisabolane-type sesquiterpenoid, (E)-3-isocyanobisabolane-7,10-diene (1), and a new epidioxyergostane-type steroid, 9(11)-dehydroaxinysterol (2), were isolated from the Okinawan sponge of the genus Axinyssa. Their structures were elucidated based on the results of spectroscopic analysis and chemical conversion. Epidioxysterol 2 was found to show significant growth inhibitory effects against human cancer cell lines.
Assuntos
Antineoplásicos/isolamento & purificação , Antineoplásicos/farmacologia , Poríferos/química , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia , Esteroides/isolamento & purificação , Esteroides/farmacologia , Alcenos/química , Animais , Antineoplásicos/química , Artemia , Catálise , Ensaios de Seleção de Medicamentos Antitumorais , Ergosterol/química , Ergosterol/isolamento & purificação , Humanos , Hidrogenação , Japão , Dose Letal Mediana , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Modelos Moleculares , Oxirredução , Sesquiterpenos/química , Esteroides/químicaRESUMO
Two novel prostanoid-related marine oxylipins, tricycloclavulone (1) and clavubicyclone (2), were isolated from the Okinawan soft coral Clavularia viridis. The structures of 1, having a tricyclo[5.3.0.0(1,4)]decane ring system, and 2, having a bicyclo[3.2.1]octane ring system, were elucidated on the basis of spectroscopic analysis. Clavubicyclone showed a moderate growth inhibition activity against tumor cells in vitro.
