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Mol Immunol ; 38(12-13): 997-1002, 2002 May.
Artigo em Inglês | MEDLINE | ID: mdl-12009579

RESUMO

The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions in the cluster that forms around a dendritic cell. These interactions are being dissected by experiments in which two populations of TCR-transgenic T cells are combined in vivo. Another important aspect of synaptic activity is the way in which different levels of expression of MHC class II molecules influence Th1/Th2 balance. In exploring this form of control we are learning something of general importance about cis-regulation.


Assuntos
Sistema Imunitário/imunologia , Modelos Imunológicos , Animais , Linfócitos B/imunologia , Adesão Celular , Células Dendríticas/imunologia , Genes MHC da Classe II , Ativação Linfocitária , Polimorfismo Genético , Regiões Promotoras Genéticas , Transdução de Sinais , Linfócitos T/imunologia
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