RESUMO
BACKGROUND: Common variable immunodeficiency is one of the main antibodies' deficiency syndromes. OBJECTIVE: To present the immunological study of a 29-year-old patient with common variable immunodeficiency who assisted to a check-up after being four years without treatment with gammaglobuline. MATERIAL AND METHODS: We studied a sample of peripheral blood and saliva of a patient with common variable immunodeficiency and that of a healthy patient (control). Assessment of immunoglobulin G, immunoglobulin A and immunoglobuin M was performed by a simple radial immunodiffusion test, and immunoglobulin E by immunoassay. Immunophenotypic study of leukocytic subpopulations was done by citometry by using the following panel of monoclonal antibodies: CD3 (Leu-4), CD4 (Leu-3a), CD8 (Leu-2a), CD19 (Leu-12), CD14 (Leu-M3), CD11a (LFA-I), CD49d (VLA-4), CD54 (ICAM-1), CD31 (PECAM). RESULTS: It was found a significant reduction in most of the serum and secretory immunoglobulins, levels of unusual expression of integrines CD11a and CD31 in lymphocytes T related to the low percentage of activated lymphocytes T/memory.
