RESUMO
Taste threshold detection and recognition were determined on 46 dyspeptic patients and on 42 blind controls. Among the dyspeptic patients 60% suffered from different taste disorders. Among the blind controls the frequency of taste disorder was 41%. Among the dyspeptic patients heterogeusia and dysgeusia dominated, threefold compared to the control blind persons. A mild hypergeusia appeared among the patients in 21%, among the blind in 8%. There was an enhanced hypergeusia in the group of blind persons (16%), but this was found in the group of dyspeptic patients in only 4%. It is suggested that the hypergeusia may also be a compensatory function, a consequence of the loss of seeing. There was an inverse ratio between the taste acuity and taste preference. The taste threshold to the preferred taste in both groups was higher, therefore more food was needed to stimulate the taste nerves.
Assuntos
Dispepsia/fisiopatologia , Limiar Gustativo/fisiologia , Paladar/fisiologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
The effect of the prostaglandin PGF2 alpha on the active Arthus reaction was examined in 20 young male rats and 12 young male rabbits because this local inflammatory reaction caused by immunocomplexes is very similar to a recurrent oral disease on humans called Sutton aphthosis, and because the amount of PGF2 alpha is higher than that of other PGs in the oral mucosa. In our experiments, the PGF2 alpha caused a very rapid and quickly-disappearing Arthus reaction when the sensitisation was pretreated by PGF2 alpha. Moreover the PGF2 alpha caused a very intensive and long-persisting Arthus reaction when the local evocation was prepared by PGF2 alpha pretreatment. The cardinal clinical symptom of the reaction was the marked oedema caused by PGF2 alpha. In the histological picture, the Arthus reaction was more intense after PGF2 alpha pretreatment. The PGF2 alpha is capable of influencing both the intensity and the duration of the Arthus reaction.
Assuntos
Reação de Arthus/fisiopatologia , Prostaglandinas F/farmacologia , Língua/fisiopatologia , Animais , Reação de Arthus/patologia , Dinoprosta , Masculino , Coelhos , Ratos , Língua/efeitos dos fármacos , Língua/patologiaRESUMO
PGF2 alpha exerts a cytoprotective effect on the oral mucous membrane against the caustics, trichloroacetic acid and silver nitrate. The prophlogistic effect of PGF2 alpha and a caustic agent acting synergistically is an exaggerated inflammatory reaction (caustic-prostaglandin reaction or CPR). Intraperitoneal pretreatment with PGF2 alpha can prevent this CPR in rats. Probably the prostaglandin pretreatment depresses the PG receptors. Intraperitoneal pretreatment with indomethacin evokes a more marked CPR in rats. Probably the indomethacine pretreatment activates the PG receptors. Histological sections of the rat oral mucosa show a much less marked reaction after PGF2 alpha pretreatment. They also show signs of more marked swelling after indomethacin pretreatment.
