RESUMO
The anti-inflammatory potential of three doses of an aqueous infusion of aerial parts Bidens tripartita L. against carrageenan-induced acute paw edema in rats was investigated. A phytochemical study and qualitative-quantitative analyses revealed the presence of flavonoids, tannins, polysaccharides, phenols, amino acids, ascorbic acid, organic acids and polyacetylenes. Infusion doses of 20ml/kgbody wt. exhibited significant anti-inflammatory activity in rats, as compared with indomethacin. In addition, the infusion showed analgesic properties in a hot-plate test and antipyretic properties in carrageenan-induced local hyperthermia, both in rats. The effects were dose-dependent. Our results provide evidence for the potential usefulness of B. tripartita infusion in the treatment of inflammatory disorders.
Assuntos
Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Bidens/química , Edema/tratamento farmacológico , Febre/tratamento farmacológico , Dor/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Analgésicos/análise , Analgésicos/farmacologia , Animais , Anti-Inflamatórios/análise , Anti-Inflamatórios/farmacologia , Carragenina , Cromatografia Líquida de Alta Pressão , Relação Dose-Resposta a Droga , Edema/induzido quimicamente , Feminino , Febre/induzido quimicamente , Temperatura Alta , Indometacina , Componentes Aéreos da Planta , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Ratos , Ratos WistarRESUMO
Review, is devoted to questions of experimental investigations of the effect of biologically active compounds of food on three metaboloms, the functionality of which influences on development of pathologic processes: 1) endothelium metabolom, which controls level of vessel tone and processes of blood coagulation; 2) pro- and antiinflammatory metabolom; 3) metabolom, taking part in maintenance of anti-oxidant status of an organism.