Exploring functional abilities and competing risks among stroke patients: a longitudinal and survival analysis study at Felege Hiwot Referral Hospital, Ethiopia.

OBJECTIVES: This study aimed to evaluate competing risks and functional ability measures among patients who had a stroke. DESIGN: A joint model comprising two related submodels was applied: a cause-specific hazard submodel for competing drop-out and stroke-related death risks, and a partial proportional odd submodel for longitudinal functional ability. SETTING: Felege Hiwot Referral Hospital, Ethiopia. PARTICIPANTS: The study included 400 patients who had a stroke from the medical ward outpatient stroke unit at Felege Hiwot Referral Hospital, who were treated from September 2018 to August 2021. RESULTS: Among the 400 patients who had a stroke, 146 (36.5%) died and 88 (22%) dropped out. At baseline, 14% of patients had no symptoms and/or disability while 24% had slight disability, and 25% had severe disability. Most patients (37.04%) exhibited moderate functional ability. The presence of diabetes increased the cause-specific hazard of death by 3.95 times (95% CI 2.16 to 7.24) but decreased the cause-specific hazard of drop-out by 95% (aHR 0.05; 95% CI 0.01 to 0.46) compared with non-diabetic patients who had a stroke. CONCLUSION: A substantial proportion of patients who had a stroke experienced mortality and drop-out during the study period, highlighting the importance of considering competing risks in stroke research. Age, diabetes, white cell count and stroke complications were significant covariates affecting both longitudinal and survival submodels. Compared with stand-alone models, the joint competing risk modelling technique offers comprehensive insights into the disease's transition pattern.

Lung cancer mortality and associated predictors: systematic review using 32 scientific research findings.

Background: Cancer is a chronic disease brought on by mutations to the genes that control our cells' functions and become the most common cause of mortality and comorbidities. Thus, this study aimed to assess the comprehensive and common mortality-related risk factors of lung cancer using more than thirty scientific research papers. Methods: Possible risk factors contributing to lung cancer mortality were assessed across 201 studies sourced from electronic databases, including Google Scholar, Cochrane Library, Web of Science (WOS), EMBASE, Medline/PubMed, the Lung Cancer Open Research Dataset Challenge, and Scopus. Out of these, 32 studies meeting the eligibility criteria for meta-analysis were included. Due to the heterogeneous nature of the studies, a random-effects model was applied to estimate the pooled effects of covariates. Results: The overall prevalence of mortality rate was 10% with a 95% confidence interval of 6 and 16%. Twenty studies (62.50%) studies included in this study considered the ages of lung cancer patients as the risk factors for mortality. Whereas, eighteen (56.25%) and thirteen (40.63%) studies incorporated the gender and smoking status of patients respectively. The comorbidities of lung cancer mortality such as cardiovascular disease, hypertension, diabetes, and pneumonia were also involved in 7 (21.90%), 6 (18.75%), 5 (15.63%), and 2 (6.25%) studies, respectively. Patients of older age are more likely to die as compared to patients of younger age. Similarly, lung patients who had smoking practice were more likely to die as compared to patients who hadn't practiced smoking. Conclusion: The mortality rate of lung cancer patients is considerably high. Older age, gender, stage, and comorbidities such as cardiovascular, hypertension, and diabetes have a significant positive effect on lung cancer mortality. The study results will contribute to future research, management, and prevention strategies for lung cancer.

Spatial multilevel analysis of age at death of under-5 children and associated determinants: EDHS 2000-2016.

OBJECTIVE: This study examines trends, spatial distribution and determinants of age at death of under-5 children in Ethiopia. DESIGN: This study used secondary data from the 2000, 2005, 2011 and 2016 Ethiopian Demographic and Health Surveys. A multilevel partial ordinal logistic regression model was used to assess the effects of variables on the age at death of children under 5 years. SETTING: Ethiopia. PARTICIPANTS: The final analysis included a sample of 3997 deaths of newborns, infants and toddlers. RESULTS: A total of 1508, 1054, 830 and 605 deaths of under-5 children were recorded in the 2000, 2005, 2011 and 2016 survey years, respectively. The death of newborns, infants and toddlers showed a significant decrease from 2000 to 2016, with reductions of 33.3% to 17.4%, 42.4% to 12.6% and 45.2% to 11.6%, respectively. The analysis using Global Moran's Index revealed significant spatial autocorrelation in mortality for each survey year (p<0.05). The intraclass correlation of age at death of under-5 children within regions was substantial. Furthermore, the odds of newborn deaths among under-5 children (OR: 0.638, 95% CI: 0.535, 0.759) were lower for those delivered in health institutions compared with those delivered at home. CONCLUSIONS: Throughout the survey years from 2000 to 2016, newborn children had higher mortality rates compared with infants and toddlers, and significant spatial variations were observed across different zones in Ethiopia. Factors such as child's sex, age of mother, religion, birth size, sex of household head, place of delivery, birth type, antenatal care, wealth index, spatial autocovariate, Demographic and Health Survey year, place of residence and region were found to be significant in influencing the death of under-5 children in Ethiopia. Overall, there has been a decreasing trend in the proportion of under-5 child mortality over the four survey years in Ethiopia.

Spatial distribution and multilevel analysis of the ideal number of children among Ethiopian women.

BACKGROUND: Ideal number of children (INC) is the number of children that a woman or man would have if they could go back to the time when they did not have any children and could choose accurately the number of children to have in their total life. Despite numerous studies on the prevalence and associated factors of the ideal number of children, there is a lack of studies that incorporated spatial and multilevel analysis. Thus, this study was aimed at the spatial and multilevel analysis of an ideal number of children and associated factors. METHODS: The study design was a cross-sectional study in which the data was obtained from Ethiopian Demographic and Health Survey (EDHS) in 2016. About 13,961 women ages 15-49 who fulfill the inclusion criterion were considered. A negative binomial regression model that incorporates spatial and multilevel analysis was employed. RESULTS: About 33 and 12.8% of the women had four and six ideal numbers of children respectively. The highest INC per woman was recorded in Oromia region 5055 (36.1%) and the lowest in Harare 35(0.2%). The INC per woman is high in rural 10,726 (76.6%) areas as compared to urban areas 3277(23.4%). The ideal number of children was spatially clustered (Global Moran's I = 0.1439, p < .00043). Significant hotspot clusters were found in the Somali region such as in Afder, Shabelle, Korahe, and Doolo zone. CONCLUSION: The spatial analysis revealed a significant clustering of the ideal number of children in the Ethiopia zone. Specifically, higher INC was observed in the Somali region, specifically in the Afder, Shabelle, Korahe, and Doolo zones. Among the various factors considered, women's age, region, place of residence, women's education level, contraception use, religion, marital status, family size, and age at first birth year were identified as significant predictors of the ideal number of children. These findings indicate that these factors play a crucial role in shaping reproductive preferences and decisions among women in the study population. Based on these findings, responsible bodies should prioritize targeted interventions and policies in high-risk regions to address women's specific reproductive needs.

Spatiotemporal distribution and bivariate binary analysis of antenatal and delivery care utilizations in Ethiopia: EDHS 2000-2016.

BACKGROUND: Antenatal care (ANC) is a maternal health care service given by skilled health professionals to pregnant women. Women may give birth at home or in health institutions. Home delivery care (DC) increases the likelihood of mortality of the mother and the newborn. Globally, each year nearly 303,000 maternal deaths occurred from complications of pregnancy and childbirth. Ethiopia alone accounted for 13,000 deaths, which disproportionately affects women living in different places of the country. Thus, this study aimed to assess the spatiotemporal patterns and associated factors of antenatal and delivery care utilization in Ethiopia. METHOD: This study used the 2000 to 2016 EDHS (Ethiopian and Demographic Health Survey) data as a source. A total weighted sample of 30,762 women (7966 in 2000, 7297 in 2005, 7908 in 2011, and 7591 in 2016) was used. The separate and bivariate logistic regression analyses with and without the spatial effect were modeled using SAS version 9.4 and ArcGIS version 10.8. RESULTS: The spatial distribution of ANC and DC was non-random in Ethiopia. The overall odds ratio of ANC and DC was 2.09. In 2016, 31.8% and 33.2% of women had ANC and DC respectively. The estimated odds of following ANC among mothers from middle and rich households were 1.346 and 1.679 times the estimated odds of following ANC among mothers from poor households respectively. Women who had attained higher education were 1.56 and 2.03 times more likely to have ANC and DC respectively compared to women who had no formal education. CONCLUSIONS: Despite the government's report that women now have better access to maternal health care, a sizable proportion of women continue to give birth at home without going to the advised antenatal care appointment. Women and husbands with low education, having non-working partners, religion, regions of dwelling, residing in rural, lower birth order, low birth interval, unable to access mass media, low wealth status, and earlier EDHS survey years were significant predictors that hinder antenatal and delivery care utilization simultaneously in Ethiopia. Whereas the spatial variable significantly affects antenatal care and being unable to access mobile phones lead to low utilization of delivery care. We recommend that policymakers, planners, and researchers consider these variables and the spatiotemporal distribution of ANC and DC to reduce maternal mortality in Ethiopia. Besides, it is recommended that further studies use the latest EDHS survey data.

Spatial distribution and trends of anemia among pregnant women in Ethiopia: EDHS 2005-2016.

Background: Anemia is a public health problem affecting both developed and developing nations worldwide with a significant consequence on health and economic growth. The problem is more severe in pregnant women. Hence, the main purpose of this study was to determine the factors of anemia levels among pregnant women in zones in Ethiopia. Methods: We utilized data from 2005, 2011, and 2016 Ethiopian demographic and health survey (EDHSs), a population-based cross-sectional study. The study includes 8,421 pregnant women. An ordinal logistic regression model with spatial analysis was used to explore factors of anemia levels among pregnant women. Result: About 224 (2.7%), 1,442 (17.2%), and 1,327 (15.8%) pregnant women were mild, moderate, and severely anemic, respectively. The spatial autocorrelation of anemia among the administrative zones of Ethiopia for the three consecutive was not significant. The middle wealth index of 15.9% (OR = 0.841, CI: 0.72-0.983) and richest wealth index of 51% (OR = 0.49, CI: 0.409-0.586) were less likely anemic compared to the poorest wealth index, age group of mother 30-39 was 42.9% (OR = 0.571, CI: 0.359-0.908) times less likely to be moderate and above anemic compared to <20 years, several household members 4-6 were 51% (OR = 1.51, CI: 1.175-1.94 more likely moderate and above anemic compared to 1-3. Conclusion: Over one-third of the pregnant women (34.5%) were anemic in Ethiopia. Wealth index, age group, religion, region, number of household members, source of drinking water, and EDHS were significant factors in anemia levels. The prevalence of anemia among pregnant women varied among Ethiopian administrative zones. North West Tigray, Waghimra, Oromia special woreda, West shewa, and East shewa were a high prevalence of anemia.

Joint modeling of longitudinal changes of blood pressure and time to remission of hypertensive patients receiving treatment: Bayesian approach.

INTRODUCTION: Hypertension is a widespread condition when the blood's force on the artery walls is extremely high to develop adverse health effects. This paper aimed to jointly model the longitudinal change of blood pressures (systolic and diastolic) and time to the first remission of hypertensive outpatients receiving treatment. METHODS: A retrospective study design was used to collect appropriate data on longitudinal changes in blood pressure and time-to-event from the medical charts of 301 hypertensive outpatients under follow-up at Felege Hiwot referral hospital, Ethiopia. The data exploration was done using summary statistics measures, individual profile plots, Kaplan-Meier plots, and log-rank tests. To get wide-ranging information about the progression, joint multivariate models were employed. RESULTS: A total of 301 hypertensive patients who take treatment was taken from Felege Hiwot referral hospital recorded between Sep. 2018 to Feb. 2021. Of this 153 (50.8%) were male, and 124 (49.2%) were residents from rural areas. About 83(27.6%), 58 (19.3%), 82 (27.2%), and 25 (8.3%) have a history of diabetes mellitus, cardiovascular disease, stroke, and HIV respectively. The median time of hypertensive patients to have first remission time was 11 months. The hazard of the patient's first remission time for males was 0.63 times less likely than the hazard for females. The time to attain the first remission for patients who had a history of diabetes mellitus was 46% lower than for those who had no history of diabetes mellitus. CONCLUSION: Blood pressure dynamics significantly affect the time to the first remission of hypertensive outpatients receiving treatment. The patients who had a good follow-up, lower BUN, lower serum calcium, lower serum sodium, lower hemoglobin, and take the treatment enalapril showed an opportunity in decreasing their blood pressure. This compels patients to experience the first remission early. Besides, age, patient's history of diabetes, patient's history of cardiovascular disease, and treatment type were the joint determinant factors for the longitudinal change of BP and the first remission time. The Bayesian joint model approach provides specific dynamic predictions, wide-ranging information about the disease transitions, and better knowledge of disease etiology.

Discrepancies of recurrent birth intervals using longitudinal data analysis in Ethiopia: interim EDHS 2019.

OBJECTIVE: This study aimed to determine whether the birth interval changes differently over time among women in Ethiopia and whether the change depends on women, children and household characteristics measured at the last visit. METHODS: Longitudinal study design was implemented based on the data obtained from the 2019 Ethiopia Mini Demographic and Health Survey consisting of a total of 3630 mothers. Generalised estimating equation and generalised linear mixed model were employed to estimate the effect of the determinants given the correlation between birth intervals within a mother is under consideration. RESULTS: The majority of women were Muslims (48.1%) and come from rural areas (82.2%). About 77.2% of women at first birth were below 20 years old. A significant correlation (p value <0.0001) between the first and second birth intervals of mothers was observed. The estimated birth interval of women from the poorest household was 0.877 (e-0.1317) times the estimated birth intervals of women from the richest household. This indicates richest households were likely to have higher birth intervals as compared with the poorest households (95% CI e-0.1754=0.839 to e-0.088=0.916). CONCLUSION: The birth intervals of over one-fifth of mothers were 1 year, less than the birth interval recommended by the WHO standard. It was also perceived that successive birth intervals are correlated. Mothers who have delivered female children had lower birth intervals than mothers who have delivered male children. As compared with the birth intervals of mothers from a household with higher economic status, the birth intervals of mothers from a household with lower economic status had lower birth intervals. In this study, significant effects of religion, contraceptive use, region, mothers' current age, education level and mothers' current marital status on birth intervals were also noted.

Potential mediators of the link between wealth index and anthropometric indices of under-five children in Ethiopia.

Background: Malnutrition of under-five children has adverse effects on child's health and development, such as growth failure and muscle wasting. The household wealth index has a direct contribution to child malnutrition despite little attention being given to its indirect effect through other factors. This study aimed to identify the potential mediators of the link between wealth index and malnutrition. Methods: In this study, a cross-sectional study design was implemented based on the data obtained from the 2019 Ethiopia Mini Demographic and Health Survey (EMDHS), which consists of a total of 3,918 under-five children. Mediation analysis of structural equation (SEM) was implemented to determine and estimate the effects of potential mediators of the link between wealth index and under-five children malnutrition. Results: Among 3,918 under-five children involved in this study, 51.4% were male children and 20.2% were from urban areas. The place of delivery of the majority of mothers (56.1%) was at home, and the majority of children were from the poorest household (36.4%). The estimated effects of height-for-age of female children were higher (1.31:95% CI = 0.45, 0.200), indicating that female children had a lower likelihood of stunting than males. As compared to children in an urban area, children from rural areas were more likely to be stunted (-0.269; 95%CI = -0.388, -0.135). The estimated total indirect effects of wealth index on stunting and underweight was 0.69 (95% = 0.045, 0.094) and 0.036 (95% = 0.013, 0.054), respectively, and significant (p-value of <0.05). Conclusion: Environmental, maternal, biological, and behavioral factors were the potential mediators of the link between the wealth index and the anthropometric indices. Besides, the total effects of the household wealth index had a significant effect on stunting, underweight, and wasting in which children from a household with low economic status were more likely to be malnourished.

Exploring and modeling recurrent birth events in Ethiopia: EMDHS 2019.

BACKGROUND: Globally, the estimated recurrent childbirth of one forth of women happens every two years or fewer. Next to Nigeria, Ethiopia is the second populist country in Africa and the first populist country in sub-Saharan Africa which consists of over 114 million population. There are prevalent short successive birth intervals problems in underdeveloped nations such as Ethiopia that contributes to adverse effects on mother and child health. However, studies that explore recurrent birth events and associated factors are very limited. Thus, this study aimed to explore and model the recurrent birth event by considering its subsequent within a mother and identifying its important determinants. As a result, the research findings of this study will be one of the preliminary research papers on the recurrent birth events that take into account the subsequent event and enable to be input for the policymakers, health institutions, and future researchers. METHODS: A total of 4676 mothers with their 16833 corresponding children were involved in this study. The data was obtained from the 2019 Ethiopian Mini Demographic and Health Survey (EMDHS). In this study, extended cox regression models such as Andersen-Gill (AG), Prentice, Williams, and Peterson total time (PWP-TT) model, PWP-gap time (PWP-GT) model, and Frailty model were employed. These all models are used to consider recurrent events within mothers and determine the potential determinants. AG, PWP-TT, and PWP-GT estimate the effect of covariates by considering the correlation between event times for a person can be explained by past events given the covariates, kth event since the entry time, kth event since the time from the previous event, respectively. RESULTS: Among mothers who have first and ninth recurrent birth events, 75.5% and 80.1% of them respectively were rural residents while 57.6% and 70.6% of them respectively were a place of delivery in the health sector. The highest prevalence of first recurrent births (44.3%) was obtained from Muslim mothers. Mothers' education level (HR: 1.210; 95%CI: 1.010, 1.460), mothers' age at first birth (HR: 0.713; 95% CI: 0.614, 0.828), household wealth index (HR: 0.776; 95% CI: 0.625, 0.965), child mortality (HR: 0.673; 95%CI: 0.514, 0.881), household size (HR: 1.914; 95%CI:1.539,2.381) and sex of child (HR:0.836; 95%CI = 0.755,0.926) were important determinants of recurrent birth event. This indicates mothers' education level and household size were positively associated with recurrent birth events. Whereas mothers' age at first birth, household wealth index, child mortality, and sex of the child was negatively associated with recurrent birth events. CONCLUSION: The WHO recommends a minimum of 33 months between two consecutive births, which is longer than the Ethiopian recurrent birth intervals observed in this study. The highest recurrent birth occurred during the age of fewer than twenty years old of mothers at first birth as compared to mothers whose age was older at first birth. Mothers, children, and household characteristics had significant effects on recurrent birth events. We authors would like to recommend communities, governmental and non-governmental stakeholders consider the associated factors of frequent recurrence of birth noticed in this study. Besides, we would also like to recommend women start birth while they got mature in age to reduce frequent recurrent birth and its corresponding adverse effects.

Screening COVID-19 Suspected Cases and Determining the Associated Factors.

Background: The incidence of corona-virus-positive persons in Africa, notably in Ethiopia, is rapidly increasing, leading to enhanced analyses. Even though the majority of people exhibit COVID-19's key symptoms, many refuse to go to the hospital to have the virus tested. This study aims to assess probable COVID-19 participants and the related characteristics among residents of Northwest Ethiopian municipal towns. Methods: This project contains participants enlisted from Northwest Ethiopia municipal towns, and a cross-sectional data collection approach was employed. A total of 1,288 arbitrarily designated contestants accomplished an actively screening test questionnaire that was used to assess whether the participants were suspected of coronavirus. The statistical analysis Chi-square test and a binary logistic regression were implemented. Results: Among the 1,288 designated contestants, 788 (61.2%) of them were men. About 77.5% of the participants were from orthodox religion and 12.2% live in the rural area permanently. As compared to female participants (45.9%), the number of suspected male participants (54.1%) was higher. As compared to societies in Woldya municipal town, populations in Bahir Dar (aOR = 0.101;95% CI = 0.065,0.156), Gondar (aOR = 0.072;95% CI = 0.043,0.122), and Debre Markos (aOR = 0.368;95% CI = 0.271,0.501) municipal town were less likely to be suspected of COVID-19. Equated to the employed contestants, unemployed contestants had lower odds of being suspected of COVID-19 (aOR = 0.147; 95% CI = 0.1160.186). Conclusion: The prevalence of suspected cases of coronavirus in Northwest Ethiopia was considerably high. The city of residence, work status, hospital use, marital status, permanent residence, and source of information were important determinants of suspected cases of coronavirus. Thus, timely diagnosis of suspected cases of coronavirus and taking the appropriate remedial action help to reduce the spread and mortality rate.

Assessing the prevalence and association between physical, emotional, and sexual of intimate partner violence against women in Nigeria.

BACKGROUND: Several studies were carried out on prevalence and associated factors of physical, emotional, and sexual violence against women. However, little attention was given to a comprehensive study that assesses the association between physical, emotional, and sexual violence against women. Thus, this study aimed to assess the association between physical, emotional, and sexual violence against women and their prevalence. METHODS: A retrospective cross-sectional design was implemented based on the 2018 Nigeria Demographic and Health Survey involving 8061 married women aged 15-49. A log-linear statistical model for the three-way table was used to assess the association between emotional, physical, and sexual violence. SAS statistical software was used for data management and parameter estimation. RESULTS: Among a total of 8061 women considered in the study 3022 (37.49%), 4216 (52.3%) and 1186 (14.71%) women have experienced physical, emotional, and sexual violence, respectively. The estimated odds of the interaction between emotional and physical violence (e1.9281 = 6.876); physical and sexual violence (e-2.0529 = 0.128) were significantly differ from 1.0 with p-values < 0:0001 and 0.0201, respectively. CONCLUSION: Over 33 percent of women experienced at least one incident of physical, emotional, or sexual violence in their lifetime. Physical violence against women has a significant association with emotional and sexual violence. However, it does not imply physical violence causes the other violence since cross-sectional data used for the analysis and other factors were not taken into consideration. The lack of a three-way association between emotional, physical, and sexual violence was also perceived. Therefore, as the prevalence of intimate partner violence against women s high, Nigeria as a country needs to strive to reduce it with the collaboration of other nations in the world to achieve Sustainable Development Goal (SDG). Design and apply guidelines to aware of the community about intimate partner violence against women and besides, take appropriate sentencing on those who commit the violence are the better approaches to prevent violence. Traditional habits that might be the cause of violence should be avoided to reduce or prevent the burden of women due to violence.

Even though studies were carried out on physical, emotional, and sexual violence against women, and prevalence and associated factors, little attention was given to a comprehensive study that assesses the association between physical, emotional, and sexual violence against women. As a result, this study aimed to assess the association between physical, emotional, and sexual acts of violence against women in Nigeria. The data was obtained from the 2018 Nigeria Demographic and Health Survey (NDHS). A total of 8061 ever married/cohabited women aged 15­49 years who were residents of the study community for at least 6 months were considered. The log-linear statistical model was used to assess the association between physical, emotional, and sexual violence against women.Of the 8061 women considered in this study, 516(6.40%) have ever been physically forced into unwanted sex by a husband/partner. About 1346 (16.70%) and 1467(18.20%) women have ever been slapped and humiliated by their husbands/partners, respectively. Whereas 3022 (37.49%), 4216 (52.3%), and 1186 (14.71%) women have experienced physical, emotional, and sexual violence, respectively. Four hundred sixty-six women were victims of physical, emotional, and sexual violence. Besides, 40, 755, and 144 women have experienced both physical and sexual violence; emotional and physical violence; and emotional and sexual violence respectively. Physical violence against women has a significant association with emotional and sexual violence. However, it does not imply physical violence causes the other violence since cross-sectional data used for the analysis and other factors were not taken into consideration.

Multilevel multivariate analysis on the anthropometric indicators of under-five children in Ethiopia: EMDHS 2019.

BACKGROUND: Undernutrition is the main cause of morbidity and mortality of children aged under five and it is an important indicator of countries' economic and health status. Limited attention is given to research papers conducted in Ethiopia that identified and estimates the determinants of under-five anthropometric indicators by considering their association and clustering effect. Therefore, this study aimed to identify and estimate the effects of important determinants of anthropometric indicators by taking into account their association and cluster effects. METHODS: In this study, a cross-sectional study design was implemented based on the data obtained from the 2019 Ethiopia Mini Demographic and Health Survey (EMDHS) consists a total of 5027 under-five children. A multilevel multivariate logistic regression model was employed to estimate the effect of the determinants given their association of anthropometric indicators and clustering effect. RESULTS: Among 5027 children considered in the study 36.0, 23.3, and 9.1% of them were stunted, underweight, and wasted, respectively. Whereas the total number of undernourished (stunting, underweight and/or wasting) children was 42.9%. More than half of the children (51.2%) were males and 77.0% lived in rural area. The estimated odds of children from households with secondary and above education levels being stunted was 0.496 (OR = 0.496) times the estimated odds of children from households with no education. Whereas children from the richest households were less likely to be stunted as compared to children from the poorest households (OR = 0.485). The estimated odds of children from urban areas being underweight and wasting were lower by 24.9 and 33.7% of estimated odds of children from rural areas respectively. CONCLUSION: The prevalence of anthropometric indicators of stunting, underweight, and wasting in Ethiopia was increased. The children underweight has significant dependency with both stunting and wasting. The sex of the child, wealth index, and education level of a household are the common important determinants of stunting, underweight and wasting. The undernourished status of children was more alike within the region and differences between regions.

Survival analysis of women breast cancer patients in Northwest Amhara, Ethiopia.

Introduction: Breast cancer, the most common cause of cancer death and the most frequently diagnosed cancer among women worldwide, ranks as the second cause of death next to lung cancer. Thus, the main objective was to assess the factors that affect the survival time of breast cancer patients using the shared frailty model. Methods: A retrospective study design was used to collect relevant data on the survival time of breast cancer patients from the medical charts of 322 breast cancer patients under follow-up at the Felege Hiwot Comprehensive Specialized Hospital (FHCSH). The data were explored using the Cox proportional hazard model, the accelerated failure time model, and shared frailty models. The model comparison was done using AIC and BIC. As a result, the Weibull gamma shared frailty model had a minimum AIC and BIC value. Result: From a total of 322 patients, about 95 (29.5%) died and 227 (70.5%) were censored. The overall mean and median estimated survival times of breast cancer patients under study were 43.7 and 45 months, respectively. The unobserved heterogeneity in the population of clusters (residence) as estimated by the Weibull-gamma shared frailty model was 0.002 (p-value = 0.000), indicating the presence of residential variation in the survival time of breast cancer patients. The estimated hazard rate of patients who had not had recurrent breast cancer was 0.724 (95% CI: 0.571, 0.917) times the estimated hazard rate of patients who had had recurrent breast cancer. Conclusion: The prevalence of breast cancer was considerably high. Under this investigation, older patients, patients in stages III and IV, anemic and diabetes patients, patients who took only chemotherapy treatment, metastasized patients, patients with an AB blood type, patients with a positive breast cancer family history, and patients whose cancer was recurrent had high death rates. Patient characteristics such as age, stage, complications, treatment, metastasis, blood type, family history, and recurrence were significant factors associated with the survival time of women with breast cancer.

Evaluating the perceptions and practices towards coronavirus and associated factors in metropolitan cities of Amhara region, Ethiopia.

Confirmed cases of coronavirus in Africa, particularly in Ethiopia, are increasing rapidly following improved testing. This study is aimed at assessing the perceptions and practices towards coronavirus among the metropolitan city population of Amhara region, Ethiopia, and examining the associated factors affecting public perceptions and practices regarding coronavirus among the population of metropolitan cities. A total of 1288 randomly selected participants completed a questionnaire designed to assess perceptions and practices towards coronavirus and associated factors. The statistical analysis involved fitting a binary logistic regression model and a chi-square test. Of 1288 study participants, 788 (61.2%) and 500 (38.8%) were male and female, respectively. Their average age and monthly income were 29.2 years and 2484 birr, respectively. Preventive measures followed by the participants involved washing hands with soap and water rubbing for at least 20 s (55.4%) and visiting a doctor when corona symptoms show up (49.5%). Permanent rural residents had lower odds of good perception and practices regarding coronavirus (aOR=0.505; 95% CI=0.15, 0.82) as compared to permanent urban resident participants. Due to misguided perceptions and practices, the prevalence of coronavirus in metropolitan city communities of Amhara region is high. The city of residence, marital status, educational level, permanent residence, and information sources were significantly associated with people's perceptions and practices towards the prevention of coronavirus. Perceptions and practices towards coronavirus had a significant positive correlation in terms of preventive measures against coronavirus. Therefore, the authors would like to recommend if substantive effort from the government and different stakeholders regarding to raising the perception and practices of communities in the cities towards the pandemic and reduce the collateral damage especially the lower income communities who cannot afford basic needs.

Sexual Violence and Other Complications of Corona Virus in Amhara Metropolitan Cities, Ethiopia.

BACKGROUND: The onset of corona virus (COVID-19) pandemic brought about multiple crises with financial, social, and political dimensions, and problems involving absence or scarcity of medication, food, and other amenities. COVID led to reports of severe hunger, stress, sexual violence, and associated complications. This study was aimed at assessing the prevalence of sexual violence, hunger, stress, indoor fighting, and related complications caused by the corona virus, and determining factors associated with it. METHODS: A cross-sectional design study involving a total of 1288 participants recruited from Amhara Metropolitan cities was implemented. Each participant completed a questionnaire regarding experience of sexual violence, hunger, stress, indoor fighting, and other complications faced due to COVID-19. A statistical analysis was done by fitting binary logistic regression model, independent t-test and Chi-squared test. RESULTS: From the total participants, 1288 (26.2%) were displaced, while 39.9% were unemployed due COVID-19. About half of the participants (48.8%) experienced general distress, 33.8% faced sexual violence, 18.2% experienced hunger, 8.4% faced indoor fighting. The majority (81.7%) of non-corona virus patients in government health-care institutions faced lack of treatment. For every unit increase of monthly income during COVID-19, the estimated odds of participants experiencing sexual violence decreased by 31.3% (aOR=0.687). Educational level, work status, and monthly salary before and during corona virus were important factors of hunger. CONCLUSION: COVID-19 pandemic led to considerably high prevalence of sexual violence, hunger, stress, and indoor fighting. Work status of participants was an important associated factor of hunger, stress, and indoor fighting. Sex of participants and their monthly income were significantly associated with increase in sexual violence during COVID-19. In addition to a general economic recession, a decrease in treatment of non-COVID-19 patients was noticed, particularly in government hospitals.

Bivariate binary analysis on composite index of anthropometric failure of under-five children and household wealth-index.

BACKGROUND: Malnutrition is the most common cause of mortality and morbidity of children in low and middle income countries including Ethiopia and household wealth index shares the highest contribution. Thus, in this study it is aimed to conduct bivariate binary logistic regression analysis by accounting the possible dependency of child composite index anthropometric failure and household wealth index. METHODS: In this study the data from Ethiopian Demographic and Health Survey (EDHS) 2016 involved 9411 under five children was considered. Child Composite Index Anthropometric Failure (CIAF) measures the aggregate child undernourished derived from the conventional anthropometric indices (stunting, underweight and wasting). The correlation between CIAF and wealth index was checked and significant correlation found. To address the dependency between the two outcome variables bivariate binary logistic regression was used to analyze the determinants of child CAIF and household wealth index jointly. RESULTS: Study results show that region, place of residence, religion, education level of women and husband/partner, sex of child, source of drinking water, household size and number of under five children in the household, mothers body mass index, multiple birth and anemia level of child had significant association with child CIAF. Female children were 0.82 times less likely to be CIAF compared to male and multiple birth children were more likely to be CIAF compared to single birth. Children from Oromia, Somalie, Gambela, SNNPR, Harari and Addis Ababa region were 0.6, 0.56, 0.67, 0.52, 0.6 and 0.44 times less likely to be CIAF compared to Tigray. A household from rural area were 15.49 times more likely poor compared to a household. The estimated odds of children whose mothers attended primary, and secondary and higher education was 0.82, and 0.52 times respectively the estimated odds of children from mothers who had never attended formal education. CONCLUSION: The prevalence of children with composite index anthropometric failure was high and closely tied with the household wealth index. Among the determinants, region, religion, family education level, and anemia level of child were statistically significant determinants of both CIAF and household wealth index. Thus, the authors recommend to concerned bodies and policymakers work on household wealth index to reduce the prevalence of child composite anthropometric failure.

Determining the effect of time dependent and time independent factors on pneumonia of children under five in North west Ethiopia.

BACKGROUND: Lower Respiratory Tract Infections including pneumonia are the fourth cause of death globally. In Ethiopia, pneumonia is the leading cause of death for children under five. However, so far, only a few studies that used longitudinal design and time dependent covariates determined the significant factors of pneumonia. This study sought to determine whether respiratory rate changes differed for under five-year-old pneumonia patients who had been receiving different treatments over time and whether the change was effected by time dependent and independent covariates. METHODS: A longitudinal study design involving marginal Poisson regression models and conditional Poisson regression models was used. After comparing the two, the final interpretation was made using a conditional Poisson regression model owing to its relative powerfulness. RESULTS: Four hundred and fifty-three under five pneumonia patients were included, of which 44.37% were female. It is found that, compared to rural children, urban children had an estimated mean respiratory rate decrease of 3%. It is also found that, compared to children whose mother practiced only exclusive breastfeeding in the first six months, children whose mother practiced both breastfed and complementary were more likely to be exposed to pneumonia. The estimated mean respiratory rate of children having asthma was 1.073 times that of children who had diarrhea. CONCLUSIONS: In northwest Ethiopia, weight, residence, previous disease history, breastfeeding and temperature are significant factors of pneumonia among children under five. The effectiveness of treatments was dependent on the number of times children visited the hospital. A significant variation of baseline pneumonia status among under five pneumonia patient children was noted in the hospital.

Wealth index and other behavioral and sociodemographic characteristics associated with body mass index in Ethiopia.

BACKGROUND: Nowadays, the burden of non-communicable diseases including obesity has been an increasing public health concern. This menace can be monitored using indexing method like body mass index. Studies indicate that socioeconomic indicators such as income, biology, behavior, and demographic factors associated with body mass index. In Ethiopia, few studies associate wealth index with body mass index in people of ages between 15 and 49. This study was aimed to assess the association of body mass index with wealth index, and behavioral and sociodemographic population characteristics. METHODS: A cross-sectional population-based study was conducted using the 2016 Ethiopian Demographic and Health Survey population of ages 15-49. A total of 10,245 individuals were considered to detect the effect of socioeconomic, biological, behavioral, and demographic factors on body mass index using logistic regression. RESULTS: The prevalence of underweight, overweight, and obesity among men are 23.8%, 6.6%, and 2.0%, respectively, which is lower than that of women (underweight 25.3%, overweight 9.1%, and obesity 2.9%). The poorest men had higher odds of being underweight (adjusted odds ratio = 2.395%; 95% confidence interval = 2.020-3.544) as compared to the richest men. Merchants and government employees have lower odds (adjusted odds ratio = 0.744; 95% confidence interval = 0.588-0.899) compared to men whose occupation is farming and labor, indicating that merchants and government employees are more likely to become overweight and obese compared to men who are farmers and laborers. CONCLUSION: It is concluded that wealth index is an important socioeconomic determinant of body mass index among men and women of age 15-49 in Ethiopia. A high prevalence of underweight, and overweight, and obesity is observed, which increases instances of non-communicable diseases. Effects of socioeconomic, biological, behavioral, and demographic indicators on body mass index differed according to sex.

Multivariate logistic regression analysis on the association between anthropometric indicators of under-five children in Nigeria: NDHS 2018.

BACKGROUND: Child malnutrition is a huge health problem having multifaceted consequences for child survival and long-term well-being. Although, several studies investigated stunting, underweight, and wasting in low- and middle-income countries, in Nigeria, the link between them received little attention. The aim of this study is, therefore, to assess the association between anthropometric indicators of under-five children such as stunting, underweight and wasting given that of other characteristics of children and households. METHODS: The data for this study was obtained from Nigerian Demographic and health survey (NDHS) in 2018. A total of 11,314 under-five children were involved. Multivariate logistic regression model was used to determine the association between stunting, underweight and wasting given that of the estimated effect of other determinants. RESULTS: From 11,314 under-five children the study considered 36.2, 21.4 and 6.7% of them suffered from stunting, underweight and wasting, respectively. About half (50.7%) of the children were male, 24.1% was obtained from North West region of Nigeria, and 37.8% of them were from households having unimproved drinking water. The pairwise dependency between stunting and underweight; underweight and wasting was measured using odds ratio (OR) of 15.796, and 16.750 respectively. The estimated odds of children from richest household to become stunted, underweight, and wasted was respectively 0.392, 0.540, 0.786 times that of the estimated odds of children from poorest households. CONCLUSION: The prevalence of under-five children with stunting, underweight and/or wasting in Nigeria was very high. The important determinants of stunting, underweight, and wasting for under five children were household wealth index, women body mass index, sex of the child, anemia, mothers' age at first birth, and a diarrhea two weeks prior to the survey. Whereas, region, religion, multiple birth, women's educational level significantly associated with both stunting and underweight. Both stunting and wasting significantly associated with underweight.