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J Pediatr ; 129(3): 424-31, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8804333

RESUMO

OBJECTIVE: To assess the incremental cost-effectiveness of prophylactic compared with episodic care in boys with severe hemophilia A. SETTING: Eleven U.S. hemophilia treatment centers. METHODS: Charge data from a randomly selected cohort of 70 boys receiving episodic infusions for bleeding events and from all 27 boys receiving infusions prophylactically were collected from documents obtained from the hemophilia treatment centers during a period of approximately 2 years. Published and public sources were used for conversion to cost, lifetime earnings, and earnings losses from disability. A model was constructed for a hypothetical patient from ages 3 to 50 years by means of three infusion scenarios. RESULTS: The cohort receiving prophylactic treatment had fewer bleeding events each year (median, 3 vs 31) but used more concentrate (3323 vs 1015 units/kg per year). Factor VIII concentrate accounted for more than 93% of the cost of both episodic and prophylactic care. Compared with episodic infusion, prophylaxis from ages 3 to 20 years costs $1100 per bleeding event prevented, in comparison with $1380 for prophylaxis from ages 3 to 50 years. The total cost of prophylactic care from ages 3 to 50 years would equal the current total cost of episodic care if the price of the concentrate were decreased by 50%. CONCLUSION: Prophylactic care markedly reduces the number of bleeding events and should prevent joint function impairment, but at substantial cost.


Assuntos
Fator VIII/administração & dosagem , Hemofilia A/economia , Hemofilia A/terapia , Hemorragia/prevenção & controle , Adolescente , Criança , Pré-Escolar , Análise Custo-Benefício , Fator VIII/economia , Hemofilia A/complicações , Hemorragia/economia , Hemorragia/etiologia , Humanos , Lactente , Masculino , Modelos Econômicos , Estados Unidos
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