Assuntos
Adenocarcinoma/análise , Adenoma/análise , Iodetos/análise , Manganês/análise , Neoplasias da Glândula Tireoide/análise , Adenocarcinoma/patologia , Adenoma/patologia , Adulto , Idoso , Feminino , Bócio/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Ativação de Nêutrons , Glândula Tireoide/análise , Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/patologiaRESUMO
Severe hypercalcemia (serum calcium, 4.37-4.84 nmol/L) was found in a 70-yr-old man who had a small cell carcinoma of the lung with multiple metastases. The plasma immunoreactive PTH concentration was markedly elevated, as measured in three different PTH assays [N-terminal PTH, 4,650 ng/L (normal, 230-630); midregion PTH, 13,850 ng/L (normal, 180-560); C-terminal PTH, 9,900 ng/L (normal, less than 1,300)], but at autopsy the parathyroid glands were histologically normal. The PTH concentration of a liver metastasis was 503.5 ng/g wet wt (normal liver, less than 4.2-5.9), and the PTH in the tumor extract eluted at nearly the same position as synthetic human PTH-(1-84) on gel filtration chromatography. Northern blot analysis revealed PTH mRNA in the tumor as a single band of 0.9 kilobase. These results indicate that the ectopic PTH production by the lung cancer was the cause of hypercalcemia in this patient.
Assuntos
Carcinoma de Células Pequenas/metabolismo , Hipercalcemia/sangue , Neoplasias Pulmonares/metabolismo , Síndromes Endócrinas Paraneoplásicas , Hormônio Paratireóideo/sangue , Idoso , Carcinoma de Células Pequenas/análise , Carcinoma de Células Pequenas/sangue , Eletroforese/métodos , Humanos , Neoplasias Hepáticas/análise , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/análise , Neoplasias Pulmonares/sangue , Masculino , Hibridização de Ácido Nucleico , Hormônio Paratireóideo/genética , RNA Mensageiro/análise , Extratos de Tecidos/análiseRESUMO
With the purpose of investigating the pathogenesis of obesity and hyperinsulinemia in rats with hypothalamic lesions (HTL), HTL were made in vagotomized rats, and the development of obesity was serially followed up to 15 weeks as well as the changes of plasma triglyceride and immunoreactive insulin (IRI) levels. Even in vagotomized rats, obesity developed after HTL and plasma triglyceride and IRI levels increased significantly. However, obesity was slightly less in grade and occurred later as compared with sham-vagotomy-HTL rats. Plasma IRI levels in vagotomized rats significantly correlated with the body weight, Lee's index, the weight of adipose tissue and plasma triglyceride level. Similar results were also obtained in rats with HTL which were pair-fed following vagotomy. These results suggest that the hyperinsulinemia in obese rats with HTL may be involved not only by hypersecretion of insulin mediated by hypothalamo-vagal nerve system but also by some insulin-antagonistic factors such as increases of adipose tissues and plasma lipids.
