RESUMO
Based on a "transition metal frustrated Lewis pair" approach, a cyclopentadienone iron tricarbonyl complex has been designed and applied in the reductive amination and hydrogenation of bicarbonate. This well-defined phosphine-free complex displays the best activities reported to date for an iron complex in the reduction of bicarbonate into formate and in reductive amination.
RESUMO
The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins.
Assuntos
Ânions/química , Gossipol/análogos & derivados , Compostos de Lítio/química , Metais/química , Naftalenos/química , Animais , Apoptose/efeitos dos fármacos , Gossipol/química , Espectroscopia de Ressonância Magnética , Camundongos , Estrutura Molecular , Proteínas Proto-Oncogênicas c-bcl-2/química , Proteínas Proto-Oncogênicas c-bcl-2/efeitos dos fármacos , EstereoisomerismoRESUMO
The single-crystal X-ray structure analysis of [RuCl(2)(C(12)H(18))(C(5)H(7)NO)] reveals a distorted piano-stool geometry around the Ru(II) atom, with a hexa-methyl-benzene ligand, two chloride ligands and a furfuryl-amine ligand, the latter coordinating through the amine group. In the crystal, a dimeric structure is observed as a result of N-Hâ¯Cl inter-actions between two symmetry-related mol-ecules.
