1.
Arzneimittelforschung
; 46(3): 273-6, 1996 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-8901148
RESUMO
The synthesis, antihyperlipaemic evaluation and quantitative structure-activity relationships (QSAR) of two series of thieno[3,2-d]pyrimidin-4-one derivatives are reported. While most of the compounds in these series were found to exhibit antihyperlipaemic activity, the QSAR study of these two series indicated a positive influence of only the electronic nature of the 2-substitutents on the biological activity. The lipophilic and the steric parameters did not appear to be significant.