RESUMO
A new tirucallane-type triterpenoid igniarine (1), and four known compounds meshimakobnol A (2), meshimakobnol B (3), ergosterol (4) and ergosterol peroxide (5), were purified from the methanol extracts of the fruiting bodies of Phellinus igniarius (DC. ex Fr.) Quél. The structure of 1 was elucidated using a combination of 1D and 2D NMR techniques and HR-ESI-MS analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumour cell lines and part of the tested compounds demonstrated weak cytotoxicity.
Assuntos
Antineoplásicos/farmacologia , Basidiomycota/química , Triterpenos/farmacologia , Antineoplásicos/isolamento & purificação , Linhagem Celular Tumoral , Ergosterol/análogos & derivados , Ergosterol/isolamento & purificação , Carpóforos/química , Células Hep G2 , Humanos , Células MCF-7 , Estrutura Molecular , Triterpenos/isolamento & purificação , VietnãRESUMO
A new cyclodepsipeptide, isarin (1), was isolated from the insect pathogenic fungus Isaria japonica Yasuda, together with one known compound, beauveriolide 1 (2). The structure of this new compound was characterized using a combination of spectroscopic and spectrometric analyses.
