Performance characterization of a novel hybrid dosimetry insert for simultaneous spatial, temporal, and motion-included dosimetry for MR-linac.

BACKGROUND: Several (online) adaptive radiotherapy procedures are available to maximize healthy tissue sparing in the presence of inter/intrafractional motion during stereotactic body radiotherapy (SBRT) on an MR-linac. The increased treatment complexity and the motion-delivery interplay during these treatments require MR-compatible motion phantoms with time-resolved dosimeters to validate end-to-end workflows. This is not possible with currently available phantoms. PURPOSE: Here, we demonstrate a new commercial hybrid film-scintillator cassette, combining high spatial resolution radiochromic film with four time-resolved plastic scintillator dosimeters (PSDs) in an MRI-compatible motion phantom. METHODS: First, the PSD's performance for consistency, dose linearity, and pulse repetition frequency (PRF) dependence was evaluated using an RW3 solid water slab phantom. We then demonstrated the MRI4D scintillator cassette's suitability for time-resolved and motion-included quality assurance for adapt-to-shape (ATS), trailing, gating, and multileaf collimator (MLC) tracking adaptations on a 1.5 T MR-linac. To do this, the cassette was inserted into the Quasar MRI4D phantom, which we used statically or programmed with artificial and patient-derived motion. Simultaneously with dose measurements, the beam-gating latency was estimated from the time difference between the target entering/leaving the gating window and the beam-on/off times derived from the time-resolved dose measurements. RESULTS: Experiments revealed excellent detector consistency (standard deviation ≤ $\le$ 0.6%), dose linearity (R2 = 1), and only very low PRF dependence ( ≤ $\le$ 0.4%). The dosimetry cassette demonstrated a near-perfect agreement during an ATS workflow between the time-resolved PSD and treatment planning system (TPS) dose (0%-2%). The high spatial resolution film measurements confirmed this with a 1%/1-mm local gamma pass-rate of 90%. When trailing patient-derived prostate motion for a prostate SBRT delivery, the time-resolved cassette measurements demonstrated how trailing mitigated the motion-induced dose reductions from 1%-17% to 1%-2% compared to TPS dose. The cassette's simultaneously measured spatial dose distribution highlighted the dosimetric gain of trailing by improving the 3%/3-mm local gamma pass-rates from 80% to 97% compared to the static dose. Similarly, the cassette demonstrated the benefit of real-time adaptations when compensating patient-derived respiratory motion by showing how the TPS dose was restored from 2%-56% to 0%-12% (gating) and 1%-26% to 1%-7% (MLC tracking) differences. Larger differences are explainable by TPS-PSD coregistration uncertainty combined with a steep dose gradient outside the PTV. The cassette also demonstrated how the spatial dose distributions were drastically improved by the real-time adaptations with 1%/1-mm local gamma pass-rates that were increased from 8 to 79% (gating) and from 35 to 89% (MLC tracking). The cassette-determined beam-gating latency agreed within ≤ $\le$ 12 ms with the ground truth latency measurement. Film and PSD dose agreed well for most cases (differences relative to TPS dose < $<$ 4%), while film-PSD coregistration uncertainty caused relative differences of 5%-8%. CONCLUSIONS: This study demonstrates the excellent suitability of a new commercial hybrid film-scintillator cassette for simultaneous spatial, temporal, and motion-included dosimetry.

Performance of the HYPERSCINT scintillation dosimetry research platform for the 1.5 T MR-linac.

Objective.Adaptive radiotherapy techniques available on the MR-linac, such as daily plan adaptation, gating, and dynamic tracking, require versatile dosimetric detectors to validate end-to-end workflows. Plastic scintillator detectors (PSDs) offer great potential with features including: water equivalency, MRI-compatibility, and time-resolved dose measurements. Here, we characterize the performance of the HYPERSCINT RP-200 PSD (MedScint, Quebec, CA) in a 1.5 T MR-linac, and we demonstrate its suitability for dosimetry, including in a moving target.Approach.Standard techniques of detector testing were performed using a Beamscan water tank (PTW, Freiburg, DE) and compared to microDiamond (PTW, Freiburg, DE) readings. Orientation dependency was tested using the same phantom. An RW3 solid water phantom was used to evaluate detector consistency, dose linearity, and dose rate dependence. To determine the sensitivity to motion and to MRI scanning, the Quasar MRI4Dphantom (Modus, London, ON) was used statically or with sinusoidal motion (A= 10 mm,T= 4 s) to compare PSD and Semiflex ionization chamber (PTW, Freiburg, DE) readings. Conformal beams from gantry 0° and 90° were used as well as a 15-beam 8 × 7.5 Gy lung IMRT plan.Main results.Measured profiles, PDD curves and field-size dependence were consistent with the microDiamond readings with differences well within our clinical tolerances. The angular dependence gave variations up to 0.8% when not irradiating directly from behind the scintillation point. Experiments revealed excellent detector consistency between repeated measurements (SD = 0.06%), near-perfect dose linearity (R2= 1) and a dose rate dependence <0.3%. Dosimetric effects of MRI scanning (≤0.3%) and motion (≤1.3%) were minimal. Measurements were consistent with the Semiflex (differences ≤1%), and with the treatment planning system with differences of 0.8% and 0.4%, with and without motion.Significance.This study demonstrates the suitability of the HYPERSCINT PSD for accurate time-resolved dosimetry measurements in the 1.5 T MR-linac, including during MR scanning and target motion.

Hybrid Cerenkov-scintillation detector validation using Monte Carlo simulations.

Objective.This study aimed at investigating through Monte Carlo simulations the limitations of a novel hybrid Cerenkov-scintillation detector and the associated method for irradiation angle measurements.Approach.Using Monte Carlo simulations, previous experimental irradiations of the hybrid detector with a linear accelerator were replicated to evaluate its general performances and limitations. Cerenkov angular calibration curves and irradiation angle measurements were then compared. Furthermore, the impact of the Cerenkov light energy dependency on the detector accuracy was investigated using the energy spectra of electrons travelling through the detector.Main results.Monte Carlo simulations were found to be in good agreement with experimental values. The irradiation angle absolute mean error was found to be less than what was obtained experimentally, with a maximum value of 1.12° for the 9 MeV beam. A 0.4% increase of the ratio of electrons having an energy below 1 MeV to the total electrons was found to impact the Cerenkov light intensity collected as a function of the incident angle. The effect of the Cerenkov intensity variation on the measured angle was determined to vary according to the slope of the angular calibration curve. While the contribution of scattered electrons with a lower energy affects the detector accuracy, the greatest discrepancies result from the limitations of the calculation method and the calibration curve itself.Significance.A precise knowledge of the limitations of the hybrid detector and the irradiation angle calculation method is crucial for a clinical implementation. Moreover, the simulations performed in this study also corroborate hypotheses made regarding the relations between multiple Cerenkov dependencies and observations from the experimental measurements.

External beam irradiation angle measurement using a hybrid Cerenkov-scintillation detector.

Objective.In this study, we propose a novel approach designed to take advantage of the Cerenkov light angular dependency to perform a direct measurement of an external beam irradiation angle.Approach.A Cerenkov probe composed of a 10 mm long filtered sensitive volume of clear PMMA optical fibre was built. Both filtered and raw Cerenkov signals from the transport fibre were collected through a single 1 mm diameter transport fibre. An independent plastic scintillation detector composed of 10 mm BCF12 scintillating fibre was also used for simultaneous dose measurements. A first series of measurements aimed at validating the ability to account for the Cerenkov electron energy spectrum dependency by simultaneously measuring the deposited dose, thus isolating signal variations resulting from the angular dependency. Angular calibration curve for fixed dose irradiations and incident angle measurements using electron and photon beams where also achieved.Main results.The beam nominal energy was found to have a significant impact on the shapes of the angular calibration curves. This can be linked to the electron energy spectrum dependency of the Cerenkov emission cone. Irradiation angle measurements exhibit an absolute mean error of 1.86° and 1.02° at 6 and 18 MV, respectively. Similar results were obtained with electron beams and the absolute mean error reaches 1.97°, 1.66°, 1.45° and 0.95° at 9, 12, 16 and 20 MeV, respectively. Reducing the numerical aperture of the Cerenkov probe leads to an increased angular dependency for the lowest energy while no major changes were observed at higher energy. This allowed irradiation angle measurements at 6 MeV with a mean absolute error of 4.82°.Significance.The detector offers promising perspectives as a potential tool for future quality assurance applications in radiotherapy, especially for stereotactic radiosurgery (SRS), magnetic resonance image-guided radiotherapy (MRgRT) and brachytherapy applications.

Lead-doped scintillator dosimeters for detection of ultrahigh dose-rate x-rays.

Objective.Lead-doped scintillator dosimeters may be well suited for the dosimetry of FLASH-capable x-ray radiotherapy beams. Our study explores the dose rate dependence and temporal resolution of scintillators that makes them promising in the accurate detection of ultrahigh dose-rate (UHDR) x-rays.Approach.We investigated the response of scintillators with four material compositions to UHDR x-rays produced by a conventional x-ray tube. Scintillator output was measured using the HYPERSCINT-RP100 dosimetry research platform. Measurements were acquired at high frame rates (400 fps) which allowed for accurate dose measurements of sub-second radiation exposures from 1 to 100 ms. Dose-rate dependence was assessed by scaling tube current of the x-ray tube. Scintillator measurements were validated against Monte Carlo simulations of the probe geometries and UHDR x-ray system. Calibration factors converting dose-to-medium to dose-to-water were obtained from simulation data of plastic and lead-doped scintillator materials.Main Results.The results of this work suggest that lead-doped scintillators were dose-rate independent for UHDR x-rays from 1.1 to 40.1 Gy s-1and capable of measuring conventional radiotherapy dose-rates (0.1 Gy s-1) at extended distance from the x-ray focal spot. Dose-to-water measured with a 5% lead-doped scintillator detector agreed with simulations within 0.6%.Significance.Lead-doped scintillators may be a valuable tool for the accurate real-time dosimetry of FLASH-capable UHDR x-ray beams.

Technical note: Characterization and practical applications of a novel plastic scintillator for online dosimetry for an ultrahigh dose rate (FLASH).

PURPOSE: Although flash radiation therapy (FLASH-RT) is a promising novel technique that has the potential to achieve a better therapeutic ratio between tumor control and normal tissue complications, the ultrahigh pulsed dose rates (UHPDR) mean that experimental dosimetry is very challenging. There is a need for real-time dosimeters in the development and implementation of FLASH-RT. In this work, we characterize a novel plastic scintillator capable of temporal resolution short enough (2.5 ms) to resolve individual pulses. METHODS: We characterized a novel plastic dosimeter for use in a linac converter to deliver 16-MeV electrons at 100-Gy/s UHPDR average dose rates. The linearity and reproducibility were established by comparing relative measurements with a pinpoint ionization chamber placed at 10-cm water-equivalent depth where the electrometer is not saturated by the high dose per pulse. The accuracy was established by comparing the plastic scintillator dose measurements with EBT-XD Gafchromic radiochromic films, the current reference dosimeter for UHPDR. Finally, the plastic scintillator was compared against EBT-XD films for online dosimetry of two in vitro experiments performed at UHPDR. RESULTS: Relative ion chamber measurements were linear with plastic scintillator response within ≤1% over 4-20 Gy and pulse frequencies (18-180 Hz). When characterized under reference conditions with NIST-traceability, the plastic scintillator maintained its dose response under UHPDR conditions and agreed with EBT-XD film dose measurements within 4% under reference conditions and 6% for experimental online dosimetry. CONCLUSION: The plastic scintillator shows a linear and reproducible response and is able to accurately measure the radiation absorbed dose delivered by 16-MeV electrons at UHPDR. The dose is measured accurately in real time with a greater level of precision than that achieved with a radiochromic film.

Characterization of an x-ray tube-based ultrahigh dose-rate system for in vitro irradiations.

PURPOSE: To present an x-ray tube system capable of in vitro ultrahigh dose-rate (UHDR) irradiation of small < 0.3 mm samples and to characterize it by means of a plastic scintillation detector (PSD). METHODS AND MATERIALS: A conventional x-ray tube was modified for the delivery of short UHDR irradiations. A beam shutter system with a sample holder was designed and installed in a close proximity of an x-ray tube window to enable <1 s irradiations at UHDR. The dosimetry was performed with a small 0.5-mm long 0.5-mm in diameter PSD irradiated with 80, 100, and 120 kVp beams and beam currents of 1-37.5 mA. The PSD signal was recorded at frame rates of 20 and 50 fps for shutter exposure between 100 and 1125 ms. Irradiation reproducibility was studied with the PSD. The x-ray tube irradiation setup was modeled with Monte Carlo (MC) and dose on a surface of a phantom was also measured with films. The effect of dose delivery uncertainty to 300-µm spheroids due to positioning and spheroid size was evaluated. RESULTS: MC simulations showed good agreement with PSD measurements acquired at both frame rates of 20 and 50 fps in terms of beam temporal profile. PSD-measured dose exhibited excellent linearity as a function of instantaneous dose rate from 3.1 to 118.0 Gy/s as well as shutter exposure time from 100 and 1125 ms for all investigated beam energies. PSD absorbed dose for the 80, 100, and 120 kVp beams agreed with MC simulations to within 5%. The total delivered doses ranged from 0.4 Gy for a 1-mA, 80 kVp beam, and 100 ms shutter exposure to 166.9 Gy for a 37.5-mA, 80 kVp beam, and a 1125 ms exposure. PSD irradiation reproducibility was < 0.5%. Simulated and measured dose fall off agreed and it was steep along the axis of the shutter slit (1%/0.1 mm) and with depth (2%/0.1 mm at 1-mm depth). Spheroid positioning uncertainty of 300 µm resulted in dose difference of < 3% for x and y shifts but up to 7% uncertainty for a z-shift parallel to the beam axis. A 16% difference in spheroid size resulted in <5% dose difference in spheroid absorbed dose. CONCLUSIONS: We have presented a cost-effective x-ray tube-based system with a beam shutter designed for in vitro UHDR delivery and reaching dose rates of up to 118.0 Gy/s. The described shutter system can be easily implemented at other institutions, which might enable new researchers to investigate the radiobiology of UHDR irradiations in vitro.

Comparative optic and dosimetric characterization of the HYPERSCINT scintillation dosimetry research platform for multipoint applications.

This study introduces the HYPERSCINT research platform (HYPERSCINT-RP100, Medscint Inc., Quebec, Canada), the first commercially available scintillation dosimetry platform capable of multi-point dosimetry through the hyperspectral approach. Optic and dosimetric performances of the system were investigated through comparison with another commercially available solution, the Ocean Optics QE65Pro spectrometer. The optical characterization was accomplished by measuring the linearity of the signal as a function of integration time, photon detection efficiency and spectral resolution for both systems under the same conditions. Dosimetric performances were then evaluated with a 3-point plastic scintillator detector (mPSD) in terms of signal to noise ratio (SNR) and signal to background ratio (SBR) associated with each scintillator. The latter were subsequently compared with those found in the literature for the Exradin W1, a single-point plastic scintillator detector. Finally, various beam measurements were realized with the HYPERSCINT platform to evaluate its ability to perform clinical photon beam dosimetry. Both systems were found to be comparable in terms of linearity of the signal as a function of the intensity. Although the QE65Pro possesses a higher spectral resolution, the detection efficiency of the HYPERSCINT is up to 1000 time greater. Dosimetric measurements shows that the latter also offers a better SNR and SBR, surpassing even the SNR of the Exradin W1 single-point PSD. While doses ranging from 1 to 600 cGy were accurately measured within 2.1% of the predicted dose using the HYPERSCINT platform coupled to the mPSD, the Ocean optics spectrometer shows discrepancies up to 86% under 50cGy. Similarly, depth dose, full width at half maximum region of the beam profile and output factors were all accurately measured within 2.3% of the predicted dose using the HYPERSCINT platform and exhibit an average difference of 0.5%, 1.6% and 0.6%, respectively.

Benchmarking a novel inorganic scintillation detector for applications in radiation therapy.

PURPOSE: The aim of this study was to investigate the contribution of Cerenkov radiation to the overall signal measured with a novel inorganic scintillating detector (ISD). METHODS: An ISD based on terbium doped gadolinium oxysulphide (Gd2O2S:Tb) was used. A hyperspectral technique separated the Cerenkov signal from the radioluminescence (RL) signal of the ISD. The relative contribution of Cerenkov radiation was evaluated under different conditions. The efficiency of using simple spectral correction to reduce the Cerenkov contribution was quantified. Other experiments investigated were the dose-per-pulse dependence observed in our previous study and the absorbed-dose energy dependence when acquiring percentage depth dose curves using Monte Carlo (MC) simulations. RESULTS: The maximum relative contribution of Cerenkov radiation was 2.10% for a 10 × 10 cm2 field at 10 cm depth. However, this percentage increased to 24% when the ISD was 7 cm out of field and exposed to a 10 × 10 cm2 field. Using 15 nm and 5 nm band-pass filters reduced the Cerenkov contribution across all experimental conditions by a maximum of 75% and 82%, respectively. The MC simulation results show discrepancies between the measured and simulated PDD profiles using the Gd2O2S:Tb scintillator at depth. CONCLUSION: This study showed that while Gd2O2S:Tb ISD provides high-signal intensity, the contribution of Cerenkov radiation under specific conditions can be significant. However, narrow band-pass filters can reduce the Cerenkov signal to a negligible level. The MC simulations suggest mechanisms other than the stem effect and the absorbed-dose energy dependence influence the response of the Gd2O2S:Tb scintillator measurements at depth.

Quality assurance for Gamma Knife Perfexion using the Exradin W1 plastic scintillation detector and Lucy phantom.

The goal of this work is to validate the use of the Exradin W1 plastic scintillation detector (PSD) to measure profiles and output factors from Gamma Knife Perfexion collimators in a Lucy phantom. The Exradin W1 PSD has a small-volume, near-water-equivalent, energy-independent sensitive element. Output measurements were performed for all 3 collimators (4 mm, 8 mm, and 16 mm) of the Gamma Knife Perfexion system, and these measurements were compared to measurements made with an A16 ion chamber and an EBT3 film and to the nominal values. We showed that a configuration in which the focus or 'shot' moves while the detector remains fixed is essentially equivalent to a configuration in which the focus is fixed while the detector moves. A Lucy phantom containing a PSD was moved in small steps to acquire profiles in all three dimensions. EBT3 film was inserted in the Lucy phantom and exposed to a single shot for each collimator. The relative values for output factors measured with the PSD were 1.000, 0.892, and 0.795, for the 16 mm, 8 mm, and 4 mm collimators, respectively. The values measured with EBT3 film were 1.000, 0.881, and 0.793, and the values measured with the A16 ion chamber were 1.000, 0.883, and 0.727. The nominal output factors for the Gamma Knife Perfexion are 1.000, 0.900, and 0.814, respectively. There was excellent agreement between all profiles measured with the PSD and EBT3 as well as with the treatment planning system data provided by the vendor. In light of our results, the Exradin W1 PSD is well suited for beam quality assurance of a Gamma Knife Perfexion irradiator.

Preclinical dose verification using a 3D printed mouse phantom for radiobiology experiments.

PURPOSE: Dose verification in preclinical radiotherapy is often challenged by a lack of standardization in the techniques and technologies commonly employed along with the inherent difficulty of dosimetry associated with small-field kilovoltage sources. As a consequence, the accuracy of dosimetry in radiobiological research has been called into question. Fortunately, the development and characterization of realistic small-animal phantoms has emerged as an effective and accessible means of improving dosimetric accuracy and precision in this context. The application of three-dimensional (3D) printing, in particular, has enabled substantial improvements in the conformity of representative phantoms with respect to the small animals they are modeled after. In this study, our goal was to evaluate a fully 3D printed mouse phantom for use in preclinical treatment verification of sophisticated therapies for various anatomical targets of therapeutic interest. METHODS: An anatomically realistic mouse phantom was 3D printed based on segmented microCT data of a tumor-bearing mouse. The phantom was modified to accommodate both laser-cut EBT3 radiochromic film within the mouse thorax and a plastic scintillator dosimeter (PSD), which may be placed within the brain, abdomen, or 1-cm flank subcutaneous tumor. Various treatments were delivered on an image-guided small-animal irradiator in order to determine the doses to isocenter using a PSD and validate lateral- and depth-dose distributions using film dosimeters. On-board cone-beam CT imaging was used to localize isocenter to the film plane or PSD active element prior to irradiation. The PSD irradiations comprised a 3 × 3 mm2 brain arc, 5 × 5 mm2 parallel-opposed pair (POP), and 5-beam 10 × 10 mm2 abdominal coplanar arrangement while two-dimensional (2D) film dose distributions were acquired using a 3 × 3 mm2 arc and both 5 × 5 and 10 × 10 mm2 3-beam coplanar plans. A validated Monte Carlo (MC) model of the source was used as to verify the accuracy of the film and PSD dose measurements. computer-aided design (CAD) geometries for the mouse phantom and dosimeters were imported directly into the MC code to allow for highly accurate reproduction of the physical experiment conditions. Experimental and MC-derived film data were co-registered and film dose profiles were compared for points above 90% of the dose maximum. Point dose measurements obtained with the PSD were similarly compared for each of the candidate (brain, abdomen, and tumor) treatment sites. RESULTS: For each treatment configuration and anatomical target, the MC-calculated and measured doses met the proposed 5% agreement goal for dose accuracy in radiobiology experiments. The 2D film and MC dose distributions were successfully registered and mean doses for lateral profiles were found to agree to within 2.3% in all cases. Isocentric point-dose measurements taken with the PSD were similarly consistent, with a maximum percentage deviation of 3.2%. CONCLUSIONS: Our study confirms the utility of 3D printed phantom design in providing accurate dose estimates for a variety of preclinical treatment paradigms. As a tool for pretreatment dose verification, the phantom may be of particular interest to researchers for its ability to facilitate precise dosimetry while fostering a reduction in cost for radiobiology experiments.

Characterization of a plastic scintillating detector for the Small Animal Radiation Research Platform (SARRP).

PURPOSE: The purpose of this study was to characterize a small plastic scintillator developed for high resolution, real-time dosimetry of therapy and imaging x-ray beams delivered by an image-guided small animal irradiator. MATERIALS AND METHODS: A 1 mm diameter, 1 mm long polystyrene BCF-60 scintillating fiber dosimeter was characterized with 220 kVp therapy and 40, 50, 60, 70, and 80 kVp imaging beams on the Small Animal Research Platform (SARRP). Scintillator output, sensitivity (charge per unit dose), linearity, and 0.2-mm resolution beam profile measurements were performed. A validated in-house Monte Carlo (MC) model of the SARRP was used to compute detailed energy spectra at locations of dosimetry, and validated scintillator measurement with MC simulations. Mass energy-absorption coefficients from the National Institute of Standards and Technology (NIST) tables convolved with MC-derived spectra were used in conjunction with Birks ionization quenching factors to correct scintillator output. An air kerma calibration method was employed to correct scintillator output for in-air beam profile measurements with open, 5 × 5, and 3 × 3 mm2 square field sizes, and compared to MC simulations. RESULTS: Scintillator dose response showed excellent linearity (R2  ≥ 0.999) for all sensitivity measurements, including output as a function of tube current. Detector sensitivity was 2.41 µC Gy-1 for the 220 kVp therapy beam, and it ranged from 1.21 to 1.32 µC Gy-1 for the 40-80 imaging beams. Percentage difference in sensitivity between the therapy and imaging beams before sensitivity correction and after using the Birks quenching factors were 52.3% and 10.2%, respectively. Percentage differences between the therapy and imaging beam sensitivities after using the air kerma calibration method for in-air measurements was excellent and below 0.3%. In-air beam profile measurements agreed to MC simulations within a mean difference of 2.4% for the 5 × 5 and 3 × 3 mm2 field sizes, however, the scintillator showed signs of volume averaging at the penumbra edges. CONCLUSIONS: A small plastic scintillator was characterized for therapy and imaging energies of a small animal irradiator, with output corrected for using an in-house MC model of the irradiator. The characterization of the scintillator detector system for small fields presents steps toward implementing real-time measurements for quality assurance and small animal treatment and imaging dose verification.

A real-time method to simultaneously measure linear energy transfer and dose for proton therapy using organic scintillators.

PURPOSE: Currently, no detectors are capable of simultaneously measuring dose and linear energy transfer (LET) in real time. In this study, we evaluated the feasibility of exploiting the difference in the response of various organic plastic scintillation detectors to measure LET and dose in therapeutic proton beams. The hypothesis behind this work was that the ratio of the responses of different scintillators exposed to the same proton beam can be used to obtain a LET vs ratio calibration curve that can then be used to infer LET under any other measurement conditions. METHODS: We first used similar scintillators with different ionization quenching factors. LET values for different irradiation conditions were calculated using a validated Monte Carlo model of the proton beam line. The quenching factors in the Birks equation for different scintillators as a function of LET were obtained from measurements in a 100-MeV pristine proton beam. We then used four different organic scintillation materials - polystyrene (BCF-12), poly (methyl methacrylate), polyvinyltoluene, and a liquid scintillator - for which the LET response varied with regard to not only quenching but also differences in material density and relative stopping power. We simultaneously exposed the four different organic scintillators and a plane-parallel ion chamber to passively scattered proton beams at fluence-averaged LET. Comparisons to the expected values obtained from the Monte Carlo simulations were made on the basis of both dose and LET. RESULTS: The maximum difference in the quenching factor was 20%, resulting in a 5% change in LET with a response ratio over a range of 5 keV/µm. Among all the scintillators investigated, the ratio of PMMA to BCF-12 provided the best correlation with LET values and was therefore used to construct the LET calibration curve. The expected LET values in the validation set were within 2% ± 6%, which resulted in dose accuracy of 1.5% ± 5.8% for the range of LET values investigated in this work. CONCLUSIONS: We demonstrated the feasibility of using the ratio of the light outputs of two organic scintillators to simultaneously measure LET and dose in therapeutic proton beams for fluence-averaged LET values from 0.47 to 1.26 keV/µm. Further studies are needed to verify the response for higher LET values and the reproducibility of this method.

Validation of plastic scintillation detectors for applications in low-dose-rate brachytherapy.

PURPOSE: To develop a plastic scintillation detector (PSD) capable of accurately measuring dose around a low-dose-rate (LDR) iodine-125 (125I) radioactive seed as a first step toward in vivo dosimetry for prostate LDR brachytherapy. METHODS: Using a GEANT4 based Monte Carlo code, photon energy distribution at any position around a realistic 125I source model was obtained. This energy distribution was convolved with the expected energy response from a plastic scintillator and dosimetry accuracy was evaluated. A PSD was constructed and validated in a water phantom for the entire range of clinically relevant positions around an 125I radioactive seed. RESULTS: The effect of energy dependence on dosimetry accuracy was shown to be limited, with a maximum relative difference of 1.2% from the calibration condition. A sophisticated approach to account for the energy dependence of PSDs is, therefore, not required if the detector is calibrated using the same model of radioactive seed or a geometrically similar one. The measurements were in good agreement with theoretical models for the entire clinical range. CONCLUSIONS: This study shows that PSDs can be used for accurate dosimetry in real time around a single 125I seed used in LDR prostate brachytherapy and is promising for clinical applications.

Determination of the Range and Spread-Out Bragg Peak Width of Proton Beams Using a Large-Volume Liquid Scintillator.

PURPOSE: To determine the range, spread-out Bragg peak (SOBP) width, and output of a passive-scattering proton beam with a liquid scintillator detector, without the need for quenching correction. MATERIALS AND METHODS: The depth-light profiles of 3 beam energies (140, 160, and 180 MeV) with 6 SOBP widths at each energy, produced in a 20 × 20 × 20-cm3 liquid scintillator tank, were collected by a charge-coupled device camera. By defining landmarks on the light signals, measured ranges and SOBP widths were acquired. A linear dependence was found between nominal and measured properties, and calibration factors were obtained by comparing those properties. The daily output stability and reproducibility of the liquid scintillator detector were studied by conducting 8 repeated measurements over 2 weeks in a 60Co beam. RESULTS: The beam ranges were determined with submillimeter accuracy without the need for any correction. The maximum difference between the measured and nominal range was 1.0 mm. The mean difference between the measured and nominal SOBP widths after correction was 0.1 mm (σ = 1.8 mm), with a maximum difference of 3.5 mm. The light output was reproducible with an SD of 0.14%. CONCLUSIONS: The method described here makes it possible to quickly and accurately determine the range and SOBP width of a passive-scattering proton beam in a liquid scintillator, without the need for quenching correction. In addition, the detector proved to be reliable over time, showing good output consistency with a high degree of precision.

A method to correct for temperature dependence and measure simultaneously dose and temperature using a plastic scintillation detector.

Plastic scintillation detectors (PSDs) work well for radiation dosimetry. However, they show some temperature dependence, and a priori knowledge of the temperature surrounding the PSD is required to correct for this dependence. We present a novel approach to correct PSD response values for temperature changes instantaneously and without the need for prior knowledge of the temperature value. In addition to rendering the detector temperature-independent, this approach allows for actual temperature measurement using solely the PSD apparatus. With a temperature-controlled water tank, the temperature was varied from room temperature to more than 40 °C and the PSD was used to measure the dose delivered from a cobalt-60 photon beam unit to within an average of 0.72% from the expected value. The temperature was measured during each acquisition with the PSD and a thermocouple and values were within 1 °C of each other. The depth-dose curve of a 6 MV photon beam was also measured under warm non-stable conditions and this curve agreed to within an average of -0.98% from the curve obtained at room temperature. The feasibility of rendering PSDs temperature-independent was demonstrated with our approach, which also enabled simultaneous measurement of both dose and temperature. This novel approach improves both the robustness and versatility of PSDs.

On the use of a single-fiber multipoint plastic scintillation detector for 192Ir high-dose-rate brachytherapy.

PURPOSE: The goal of this study was to prove the feasibility of using a single-fiber multipoint plastic scintillation detector (mPSD) as an in vivo verification tool during (192)Ir high-dose-rate brachytherapy treatments. METHODS: A three-point detector was built and inserted inside a catheter-positioning template placed in a water phantom. A hyperspectral approach was implemented to discriminate the different optical signals composing the light output at the exit of the single collection optical fiber. The mPSD was tested with different source-to-detector positions, ranging from 1 to 5 cm radially and over 10.5 cm along the longitudinal axis of the detector, and with various integration times. Several strategies for improving the accuracy of the detector were investigated. The device's accuracy in detecting source position was also tested. RESULTS: Good agreement with the expected doses was obtained for all of the scintillating elements, with average relative differences from the expected values of 3.4 ± 2.1%, 3.0 ± 0.7%, and 4.5 ± 1.0% for scintillating elements from the distal to the proximal. A dose threshold of 3 cGy improved the general accuracy of the detector. An integration time of 3 s offered a good trade-off between precision and temporal resolution. Finally, the mPSD measured the radioactive source positioning uncertainty to be no more than 0.32 ± 0.06 mm. The accuracy and precision of the detector were improved by a dose-weighted function combining the three measurement points and known details about the geometry of the detector construction. CONCLUSIONS: The use of a mPSD for high-dose-rate brachytherapy dosimetry is feasible. This detector shows great promise for development of in vivo applications for real-time verification of treatment delivery.

On the nature of the light produced within PMMA optical light guides in scintillation fiber-optic dosimetry.

The goal of this study was to evaluate the nature of the stem effect light produced within an optical fiber, to quantify its composition, and to evaluate the efficiency of the chromatic technique to remove the stem effect. Spectrometry studies were performed during irradiations of a bare PMMA optical fiber with kilovoltage x-rays from a superficial therapy unit, an Ir-192 high-dose-rate brachytherapy source, a Co-60 external-therapy unit, and megavoltage electrons and x-rays from a linear accelerator. Stem effect spectra can be accurately modeled by a linear combination of the Cerenkov light and fluorescence emitted spectra. Fluorescence light contributes more for lower-energy modalities. Cerenkov light contributes more as the energy increases above the threshold for its production. The chromatic stem effect removal technique is accurate in most of the situations. However, noticeable differences were obtained between very specific high-energy irradiation conditions. It would be advantageous to implement an additional channel in the chromatic stem effect removal chain or implement a spectral approach to independently remove the Cerenkov and the fluorescence components from the signal of interest. This would increase the accuracy and versatility of the actual chromatic stem effect removal technique.

A mathematical formalism for hyperspectral, multipoint plastic scintillation detectors.

The aim of this paper is to generalize and extend the mathematical formalism used with plastic scintillation detectors (PSDs). By doing so, we show the feasibility of multi-point PSD. The new formalism is based on the sole hypothesis that a PSD optical signal is a linear superposition of spectra. Two calibration scenarios were developed. Both involve solving a linear equation of the form Y = XB, but the process and input data depend on the information available on the detector system. Simulations were carried out to validate both scenarios and demonstrate the advantages of the new formalism. In this paper, we prove the following results. (1) Multi-point PSDs are feasible. Simulations have shown that six different spectra could be resolved accurately even in the presence of up to 10% Gaussian noise. (2) The new formalism leads to more precise PSD measurements. (3) By using the condition number of the measurement matrix, the ideal sets of calibration measurements can be identified. (4) By using principal component analysis it was possible to identify the best set of wavelength filters. We have shown through numerical simulations that multi-point detectors are feasible. This has potential for applications such as in vivo dose verification. Furthermore, our new formalism can be used to improve the robustness and ease of use of PSDs.

Development of a novel multi-point plastic scintillation detector with a single optical transmission line for radiation dose measurement.

The goal of this study was to develop a novel multi-point plastic scintillation detector (mPSD) capable of measuring the dose accurately at multiple positions simultaneously using a single optical transmission line. A 2-point mPSD used a band-pass approach that included splitters, color filters and an EMCCD camera. The 3-point mPSD was based on a new full-spectrum approach, in which a spectrograph was coupled to a CCD camera. Irradiations of the mPSDs and of an ion chamber were performed with a 6 MV photon beam at various depths and lateral positions in a water tank. For the 2-point mPSD, the average relative differences between mPSD and ion chamber measurements for the depth-dose were 2.4±1.6% and 1.3±0.8% for BCF-60 and BCF-12, respectively. For the 3-point mPSD, the average relative differences over all conditions were 2.3±1.1%, 1.6±0.4% and 0.32±0.19% for BCF-60, BCF-12 and BCF-10, respectively. This study demonstrates the practical feasibility of mPSDs. This type of detector could be very useful for pre-treatment quality assurance applications as well as an accurate tool for real-time in vivo dosimetry.