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J Atten Disord ; 18(2): 117-22, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22713361

RESUMO

OBJECTIVE: ADHD is common among children with comorbidity of enuresis. Findings concerning prepulse inhibition (PPI) of startle reflexes are controversial. Although PPI is improved through desamino-arginine vasopressin (dDAVP) in enuresis, some patients also improve concomitant ADHD through dDAVP. This study aims to evaluate whether methylphenidate (MPH) also improves PPI in ADHD. METHOD: Nineteen ADHD patients were investigated in a prospective, double-blind, crossover study with MPH versus placebo. PPI was measured as a reduction of acoustic startle reflexes. Subgroups of gender, ADHD subtype, and baseline PPI were analyzed. RESULTS: Median baseline PPI of ADHD patients (51.7%) was below the value of age-matched normal controls (73%, p = .090). MPH showed no improvement in the whole group, or the subgroups gender or subtype. Reduced baseline PPI was significantly improved (22.5%-39.3%, p = .039). CONCLUSION: Heterogeneity of ADHD is confirmed with a wide range of baseline PPI. The improvement of reduced baseline PPI through MPH suggests impaired sensorimotor gating in this subgroup.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Estimulantes do Sistema Nervoso Central/uso terapêutico , Metilfenidato/uso terapêutico , Inibição Reativa , Reflexo de Sobressalto/efeitos dos fármacos , Estimulação Acústica , Adolescente , Criança , Estudos Cross-Over , Desamino Arginina Vasopressina/uso terapêutico , Método Duplo-Cego , Enurese/tratamento farmacológico , Enurese/etiologia , Feminino , Humanos , Masculino , Estudos Prospectivos , Reflexo de Sobressalto/fisiologia , Resultado do Tratamento
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