RESUMO
Sixty-three patients with mild to moderate hypertension completed a double-blind, randomised crossover trial of atenolol 100 mg daily, enalapril 20 mg daily and the fixed combination atenolol 50 mg and nifedipine retard 20 mg (Tenif) once daily. In the three areas of efficacy that the study compared-24-hour post dose blood pressure, control of blood pressure over the dosing period with particular reference to the waking day and attenuation of systolic blood pressure on exercise-atenolol and the fixed combination demonstrated greater efficacy than enalapril.
Assuntos
Atenolol/uso terapêutico , Enalapril/uso terapêutico , Hipertensão/tratamento farmacológico , Nifedipino/uso terapêutico , Método Duplo-Cego , Combinação de Medicamentos , Feminino , Humanos , MasculinoRESUMO
In this randomized, double-blind, cross-over study we investigated the haemodynamic effects of a beta-blocker (atenolol 50 mg) and a calcium antagonist (nifedipine SR 20 mg) given either separately or in combination in three groups of hypertensive patients. Each treatment was administered twice daily. The fixed combination given twice daily for four weeks produced reductions in blood pressure which lasted for at least 12 h after administration of the last dose. The control of blood pressure by the combination was superior to that achieved by its individual components. Adverse effects normally associated with nifedipine were less frequent when it was given with atenolol. Compliance with treatment was good, but best when the drugs were given together rather than separately. A fixed combination of atenolol and nifedipine may prove useful in treating hypertensive patients inadequately controlled on beta-blocker therapy alone.
Assuntos
Atenolol/uso terapêutico , Hipertensão/tratamento farmacológico , Nifedipino/uso terapêutico , Adulto , Idoso , Atenolol/administração & dosagem , Atenolol/efeitos adversos , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Método Duplo-Cego , Combinação de Medicamentos , Quimioterapia Combinada , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Nifedipino/administração & dosagem , Nifedipino/efeitos adversos , Cooperação do Paciente , Distribuição AleatóriaRESUMO
This randomised, double-blind, crossover study investigated the haemodynamic effects of a beta-blocker (atenolol 50mg) and a calcium antagonist (sustained release nifedipine 20mg) given either separately or in combination in 3 groups of patients with mild to moderate essential hypertension. Each treatment was administered twice daily. The fixed combination given twice daily for 4 weeks produced reductions in blood pressure which lasted for at least 12 hours after administration of the final dose. The control of blood pressure by the combination was superior to that achieved by its individual components. Side effects normally associated with nifedipine therapy were less frequent when it was administered with atenolol. Compliance with treatment was good, but it was best when the drugs were given together rather than separately. A fixed combination of atenolol and nifedipine may prove useful in treating hypertensive patients inadequately controlled on beta-blocker therapy alone.
Assuntos
Atenolol/uso terapêutico , Hipertensão/tratamento farmacológico , Nifedipino/uso terapêutico , Adulto , Idoso , Atenolol/administração & dosagem , Atenolol/efeitos adversos , Pressão Sanguínea/efeitos dos fármacos , Ensaios Clínicos como Assunto , Creatinina/sangue , Método Duplo-Cego , Quimioterapia Combinada , Tolerância a Medicamentos , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Nifedipino/administração & dosagem , Nifedipino/efeitos adversos , Potássio/sangue , Distribuição Aleatória , Ácido Úrico/sangueAssuntos
Hipertensão/tratamento farmacológico , Propranolol/administração & dosagem , Ensaios Clínicos como Assunto , Formas de Dosagem , Método Duplo-Cego , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Propranolol/efeitos adversos , Fatores de TempoRESUMO
In controlled trials of the beta-adrenergic blocking drugs oxprenolol and practolol in hypertension both drugs were well tolerated without side effects and caused statistically significant non-postural reduction of blood pressure. In less than half the patients on eitherdrug the reduction of blood pressure was clinically adequate. No attempt was made to compare the two drugs.