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Molecules ; 15(3): 1453-65, 2010 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-20335993

RESUMO

Nephelium lappaceum is a tropical fruit whose peel possesses antioxidant properties. Experiments on the isolation and identification of the active constituents were conducted, and on their antioxidant activity using a lipid peroxidation inhibition assay. The methanolic extract of N. lappaceum peels exhibited strong antioxidant properties. Sephadex LH-20 chromatography was utilized in the isolation of each constituent and the antioxidant properties of each was studied. The isolated compounds were identified as ellagic acid (EA) (1), corilagin (2) and geraniin (3). These compounds accounted for 69.3% of methanolic extract, with geraniin (56.8%) as the major component, and exhibited much greater antioxidant activities than BHT in both lipid peroxidation (77-186 fold) and DPPH* (42-87 fold) assays. The results suggest that the isolated ellagitannins, as the principal components of rambutan peels, could be further utilized as both a medicine and in the food industry.


Assuntos
Antioxidantes/química , Fenóis/química , Sapindaceae/química , Antioxidantes/farmacologia , Cromatografia Líquida de Alta Pressão , Peroxidação de Lipídeos/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Fenóis/farmacologia , Espectrometria de Massas por Ionização por Electrospray
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