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J Agric Food Chem ; 64(18): 3533-7, 2016 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-27086840

RESUMO

Due to the key roles of auxins as master regulators of plant growth, there is considerable interest in the development of compounds with auxin-like properties for growth management and weed control applications. Herein, we describe the design and multistep synthesis of ten compounds bearing combinations of functional groups commonly associated with auxin-type properties. Following synthesis, these compounds were tested against multiple weed species as well as sweet corn. In general, while these structures were not quite as active as commercial auxin mimic herbicides, multiple compounds exhibited broadleaf weed activity with concurrent selectivity in sweet corn (Zea mays L. var. saccharum). In addition, differential results were observed upon subtle changes to structure, providing insights into the structural properties required for activity.


Assuntos
Herbicidas/síntese química , Herbicidas/farmacologia , Ácidos Indolacéticos/síntese química , Ácidos Indolacéticos/farmacologia , Desenho de Fármacos , Avaliação de Medicamentos , Herbicidas/química , Ácidos Indolacéticos/química , Plantas Daninhas/efeitos dos fármacos , Zea mays/efeitos dos fármacos
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