1.
J R Soc Med
; 87(12): 725-6, 1994 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7853293
2.
Lancet
; 1(7957): 441-4, 1976 Feb 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-55716
RESUMO
Lymphocytes from 12 of 17 patients with chronic active hepatitis were cytotoxic towards isolated hepatocytes in a microcytotoxicity assay. Enriched fractions of B cells, prepared by removal of E-rosetted cells, were cytotoxic in all 12 cases, whereas T-cell fractions, prepared by removal of erythrocyte-antibody-complement-rosetted cells, were cytotoxic in only 1 case (P less than 0-0005). HBsAg positive and negative cases reacted similarly. In 6 patients the addition of 5 mug aggregated IgG significantly reduced cytotoxicity from 54% +/- 15 to 13% +/- 15 (mean +/- 1S.D.) suggesting that K cells may be the effector cell in an antibody-dependent, cell-mediated reaction directed against a liver-specific membrane lipoprotein.
Assuntos
Doenças Autoimunes/imunologia , Testes Imunológicos de Citotoxicidade , Hepatite/imunologia , Fígado/citologia , Adulto , Idoso , Autoanticorpos/isolamento & purificação , Linfócitos B/imunologia , Doença Crônica , Técnicas de Cultura , Feminino , Hepatite/patologia , Humanos , Lipoproteínas/imunologia , Fígado/imunologia , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Linfócitos T/imunologia
3.
Virology
; 28(2): 348-50, 1966 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-5932841