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2.
Artigo em Inglês | MEDLINE | ID: mdl-24110220

RESUMO

The ALPE Essential device for model-based measurement of pulmonary gas exchange status may be a useful alternative to current methods for diagnosing, monitoring and evaluating treatment related to pulmonary gas exchange. In this study, shunt and ventilation/perfusion mismatch were measured with ALPE Essential in 106 healthy subjects with the aim of investigating the influence of age, posture and gender on gas exchange parameters and evaluating the test-retest reliability of the measurements. Age and gender did not have statistically significant influence on gas exchange parameters, although there was a tendency for poorer matching of ventilation and perfusion with age. Posture was shown to be important when measuring gas exchange parameters. Absolute measurement reliability was acceptable with future studies in patients being necessary for accurate evaluation of relative reliability.


Assuntos
Postura , Troca Gasosa Pulmonar , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Reprodutibilidade dos Testes , Testes de Função Respiratória , Fatores Sexuais , Adulto Jovem
3.
J Clin Monit Comput ; 27(3): 341-50, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23430364

RESUMO

The automatic lung parameter estimator (ALPE) method was developed in 2002 for bedside estimation of pulmonary gas exchange using step changes in inspired oxygen fraction (FIO2). Since then a number of studies have been conducted indicating the potential for clinical application and necessitating systems evolution to match clinical application. This paper describes and evaluates the evolution of the ALPE method from a research implementation (ALPE1) to two commercial implementations (ALPE2 and ALPE3). A need for dedicated implementations of the ALPE method was identified: one for spontaneously breathing (non-mechanically ventilated) patients (ALPE2) and one for mechanically ventilated patients (ALPE3). For these two implementations, design issues relating to usability and automation are described including the mixing of gasses to achieve FIO2 levels, and the automatic selection of FIO2. For ALPE2, these improvements are evaluated against patients studied using the system. The major result is the evolution of the ALPE method into two dedicated implementations, namely ALPE2 and ALPE3. For ALPE2, the usability and automation of FIO2 selection has been evaluated in spontaneously breathing patients showing that variability of gas delivery is 0.3 % (standard deviation) in 1,332 breaths from 20 patients. Also for ALPE2, the automated FIO2 selection method was successfully applied in 287 patient cases, taking 7.2 ± 2.4 min and was shown to be safe with only one patient having SpO2 < 86 % when the clinician disabled the alarms. The ALPE method has evolved into two practical, usable systems targeted at clinical application, namely ALPE2 for spontaneously breathing patients and ALPE3 for mechanically ventilated patients. These systems may promote the exploration of the use of more detailed descriptions of pulmonary gas exchange in clinical practice.


Assuntos
Troca Gasosa Pulmonar/fisiologia , Testes de Função Respiratória/instrumentação , Algoritmos , Teorema de Bayes , Desenho de Equipamento , Humanos , Modelos Biológicos , Monitorização Fisiológica/instrumentação , Monitorização Fisiológica/estatística & dados numéricos , Oxigênio/fisiologia , Respiração Artificial , Testes de Função Respiratória/estatística & dados numéricos , Relação Ventilação-Perfusão/fisiologia
4.
Med Biol Eng Comput ; 50(1): 43-51, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22105216

RESUMO

Management of mechanical ventilation in intensive care patients is complicated by conflicting clinical goals. Decision support systems (DSS) may support clinicians in finding the correct balance. The objective of this study was to evaluate a computerized model-based DSS for its advice on inspired oxygen fraction, tidal volume and respiratory frequency. The DSS was retrospectively evaluated in 16 intensive care patient cases, with physiological models fitted to the retrospective data and then used to simulate patient response to changes in therapy. Sensitivity of the DSS's advice to variations in cardiac output (CO) was evaluated. Compared to the baseline ventilator settings set as part of routine clinical care, the system suggested lower tidal volumes and inspired oxygen fraction, but higher frequency, with all suggestions and the model simulated outcome comparing well with the respiratory goals of the Acute Respiratory Distress Syndrome Network from 2000. Changes in advice with CO variation of about 20% were negligible except in cases of high oxygen consumption. Results suggest that the DSS provides clinically relevant and rational advice on therapy in agreement with current 'best practice', and that the advice is robust to variation in CO.


Assuntos
Sistemas de Apoio a Decisões Clínicas , Modelos Biológicos , Respiração Artificial/métodos , Idoso , Simulação por Computador , Cuidados Críticos/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Troca Gasosa Pulmonar/fisiologia , Estudos Retrospectivos
5.
J Crit Care ; 26(6): 637.e5-637.e12, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21454039

RESUMO

PURPOSE: The purpose of this study was to evaluate Danish clinicians' opinions toward ventilator settings using standardized model-simulated patients. The models ensured that all clinicians received identical presentations of data and anticipated responses to changes in patient state, enabling opinions on the same patient cases to be obtained from different clinicians. MATERIALS AND METHODS: Ten Danish intensive care clinicians' and a computerized decision support system each provided suggestions for respiratory frequency (f), tidal volume (Vt) and insoired oxygen fraction (FiO2) in the same 10 model-simulated patient cases. The 110 suggestions were then evaluated by the 10 clinicians in a ranking and classification procedure. RESULTS: Clinicians' preferences toward ventilator settings (Fio(2), Vt, and f) and the resulting simulated values of arterial oxygen saturation, peak inspiratory pressure, and pH were significantly different (P < .005). The results of the classification showed that clinicians generally had poor opinion of the advice provided by other clinicians and the decision support system, considering this advice to be unacceptable in 33% of cases and good only in 21%. The ranking procedure also showed that clinicians did not agree on the best and worst advice. CONCLUSION: The present study shows significant difference in opinion on appropriate settings of f, Vt, and Fio(2) in the same computerized decision support system model-simulated patient cases.


Assuntos
Simulação por Computador , Guias de Prática Clínica como Assunto , Padrões de Prática Médica , Respiração Artificial , Cuidados Críticos , Técnicas de Apoio para a Decisão , Dinamarca , Feminino , Humanos , Unidades de Terapia Intensiva , Masculino , Troca Gasosa Pulmonar
6.
J Crit Care ; 25(3): 367-74, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20149586

RESUMO

PURPOSE: The aim of the study was to prospectively evaluate a decision support system for its ability to provide appropriate suggestions of inspired oxygen fraction in intensive care patients comparing with levels used by clinicians in attendance. MATERIALS AND METHODS: Thirteen mechanically ventilated patients were studied in an intensive care unit where up to 4 experiments were performed during 2 consecutive days. Inspired oxygen fraction was selected in each experiment by both the decision support system and attending clinicians, and each selection was evaluated by measuring arterial oxygen saturation. RESULTS: Median (interquartile range [range]) changes in inspired oxygen fraction from baseline level by attending clinicians and the decision support system were 0.00 (-0.05 to 0.00 [-0.10 to 0.05]) and -0.03 (-0.07 to 0.01 [-0.16 to 0.12]), respectively. Clinician ranges of inspired oxygen fraction and arterial oxygen saturation were 0.25 to 0.70 and 0.92 to 0.99, respectively. Decision support system ranges of inspired oxygen fraction and arterial oxygen saturation were 0.26 to 0.54 and 0.94 to 0.99, respectively. CONCLUSIONS: The decision support system selects appropriate levels of inspired oxygen fraction in intensive care patients and could be used for automatic frequent assessment of patients, freeing the focus of clinicians to concentrate on more challenging therapy.


Assuntos
Cuidados Críticos/métodos , Sistemas de Apoio a Decisões Clínicas , Oxigenoterapia/instrumentação , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Estudos Prospectivos , Reprodutibilidade dos Testes , Respiração Artificial
7.
Comput Methods Programs Biomed ; 92(2): 205-12, 2008 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-18715670

RESUMO

Selecting appropriate ventilator settings decreases the risk of ventilator-induced lung injury. A decision support system (DSS) has been developed based on physiological models, which can advise on setting of tidal volume (Vt), respiratory frequency (f) and fraction of inspired oxygen (FiO2). The aim of this study is to assess the feasibility of the DSS by comparing its advice with the values used in clinical practice. Data from 20 patients following uncomplicated coronary artery bypass grafting (CABG) with cardiopulmonary bypass was used to test the DSS. Ventilator settings suggested by the DSS were compared to the settings selected by the clinician. When compared to the clinician the DSS suggested: lowering FiO2 (by median 7%, range 2-17%) at high SpO2 and increasing FiO2 (by median 2%, range 1-5%) at low SpO2; lowering ventilation volume (by median 0.57 l min(-1), range 0.2-1.1 l min(-1)) at high pHa and increasing ventilation volume (by median 0.4 l min(-1), range 0.1-0.9 l min(-1)) at low pHa. Suggested changes in ventilation volume were such that simulated values of PIP were < or = 22.9 cmH2O and respiratory frequency < or = 18 breaths min(-1). In all cases, computer suggested values of FiO2, Vt or f were consistent with maintaining sufficient oxygenation, normalising pH and obtaining low values of PIP.


Assuntos
Ponte de Artéria Coronária/estatística & dados numéricos , Doença da Artéria Coronariana/cirurgia , Unidades de Cuidados Coronarianos/estatística & dados numéricos , Sistemas de Apoio a Decisões Clínicas/estatística & dados numéricos , Respiração Artificial/instrumentação , Ponte de Artéria Coronária/métodos , Doença da Artéria Coronariana/fisiopatologia , Estudos de Viabilidade , Humanos , Modelos Psicológicos , Respiração Artificial/métodos , Estudos Retrospectivos
8.
Intensive Crit Care Nurs ; 21(4): 220-5, 2005 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16039959

RESUMO

A multicentre study in five postanaesthesia care units (PACUs) was performed to investigate patient and staff opinion of a specially designed music environment (DME), related to geographical location. Patients (325) and staff (91) described their opinion by means of a questionnaire-anonymously in the case of staff. Patients were not asked beforehand for permission to play music. Amongst patients 267 (83%) found the sound environment with DME pleasant or very pleasant, 26 (6%) found it unpleasant, whereas 32 (11%) answered "no opinion". The opinion of the patients did not differ significantly with geographical location. A strong correlation (P<0.05) between a positive attitude towards DME and degree of relaxation and satisfaction with stay was found. The staff had an equally positive attitude towards the DME; but theirs varied significantly with location. The opinion of the staff was more similar concerning the beneficial effect on working conditions and distress, but varied still significantly. The opinion of the staff had no demonstrable impact on that of the patients.


Assuntos
Ambiente de Instituições de Saúde , Musicoterapia , Cuidados Pós-Operatórios , Sala de Recuperação , Atitude do Pessoal de Saúde , Dinamarca , Feminino , Humanos , Masculino , Satisfação do Paciente , Estatísticas não Paramétricas
9.
Intensive Care Med ; 29(5): 727-34, 2003 May.
Artigo em Inglês | MEDLINE | ID: mdl-12698242

RESUMO

OBJECTIVE: To investigate whether parameters describing pulmonary gas exchange (shunt and ventilation-perfusion mismatch) can be estimated consistently by the use of non-invasive data as input to a mathematical model of oxygen transport. DESIGN: Prospective study. SETTING: Investigations were carried out in the post-anaesthesia care unit, coronary care unit, and intensive care unit. PATIENTS: Data from ninety-five patients and six normal subjects were included for the comparison. The clinical situations differed, ranging from healthy subjects to patients with acute respiratory failure in the intensive care unit. MEASUREMENTS: The experimental procedure involved changing the inspired oxygen fraction (F(I)O(2)) in 4-6 steps in order to obtain arterial oxygen saturations (S(a)O(2)) in the range from 90-100%. This procedure allows plotting a F(I)O(2)/S(a)O(2) or F(E)O(2)/S(a)O(2) curve, the shape and position of which was quantified using the mathematical model estimating pulmonary shunt and a measure of ventilation-perfusion mismatch (DeltaPO(2)). This procedure was performed using either arterial blood samples at each F(I)O(2) level (invasive approach) or using values from the pulse oximeter (non-invasive approach). MAIN RESULTS: The model provided good fit to data using both the invasive and non-invasive experimental approach. The parameter estimates were linearly correlated with highly significant correlation coefficients; shunt(invasive) vs shunt(non-invasive), r(2) = 0.74, P <0.01, and DeltaPO(2)(invasive) vs DeltaPO(2)(non-invasive), r(2) = 0.97, P <0.001. CONCLUSIONS: Pulmonary gas exchange can be described equally well using non-invasive data. The simplicity of the non-invasive approach makes the method suitable for large-scale clinical use.


Assuntos
Modelos Biológicos , Monitorização Fisiológica/métodos , Troca Gasosa Pulmonar , Relação Ventilação-Perfusão/fisiologia , Humanos , Oximetria , Estudos Prospectivos , Respiração Artificial , Sensibilidade e Especificidade
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