Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Leucemia-Linfoma de Células T do Adulto/tratamento farmacológico , Neoplasias do Mediastino/tratamento farmacológico , Síndrome de Lise Tumoral/etiologia , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Humanos , Masculino , Estudos Multicêntricos como Assunto , Síndrome de Lise Tumoral/terapiaRESUMO
Between 1984 and 1987 14 patients with acute non-lymphocytic leukemia were treated with sequential high-dose cytosine arabinoside in combination with asparaginase. Twelve patients were suffering from refractory leukemia; in these patients complete remissions were achieved in 58%. The efficacy of this schedule was much better in patients with substantial leukemia cell reduction due to antecedent conventional therapy and no more than 25% blast cells in the bone marrow. In this subgroup complete remissions were achieved in 75% and 86% respectively, taking into account only the completed treatment courses. Beside the well-known side-effects such as alopecia, nausea, vomiting and hepatotoxicity, we observed an increase in severe infections. Three patients died of pulmonary mycosis.