RESUMO
A small series of pyrazoles and isoxazoles derived from thiochroman-4-one has been synthesized and characterized. The compounds were examined for their in vitro inhibitory activity against Bacillus subtilis and Pseudomonas fluorescens. Among the tested compounds the pyrazole derivative from thiochroman-4-one was found to be the most effective inhibitor of growth of B. subtilis. Extensive H NMR analysis was recorded for all compounds.
Assuntos
Antibacterianos/síntese química , Benzopiranos/síntese química , Cromanos/síntese química , Compostos Heterocíclicos/síntese química , Animais , Bacillus subtilis/efeitos dos fármacos , Células Cultivadas , Cromanos/farmacologia , Cromanos/uso terapêutico , Dactinomicina/uso terapêutico , Sinergismo Farmacológico , Leucemia L1210/tratamento farmacológico , Masculino , Camundongos , Mitomicinas/uso terapêutico , Pseudomonas fluorescens/efeitos dos fármacos , Piranos/farmacologia , Piranos/uso terapêuticoRESUMO
A proton-magnetic-resonance study of the complex formed between actinomycin D and 10,11-dihydro-3H-naphth[1,2-g]indazol-7-ol strongly suggests that the indazole lies above the phenoxazine ring of actinomycin D. The complex can be destroyed by addition of dimethyl sulphoxide or dimethylformamide. The actinomycin D-indazole complex inhibits growth of Pseudomonas fluorescens and raises the thermal denaturation response of DNA. These data support the hypothesis that a molecular complex is formed which readily inhibits cell growth and interacts with DNA.
