RESUMO
OBJECTIVE: To analyze drug resistance status of Pseudomonas aeruginosa in the two-drug regimens in laboratory and clinical settings for more appropriate application of antibiotics. METHODS: The laboratory data of drug resistance rate of Pseudomonas aeruginosa identified with Biomerieux Vitek 32 system were collected. The clinical two-drug regimen data corresponding to anti-microbial sensitivity test were investigated, and the resistance rate of the clinical two-drug regimen was analyzed statistically. RESULTS: The isolation rate of Pseudomonas aeruginosa with multi-drug resistance increased steadily in recent years, and the resistance rate to 6 widely used antibiotics increased by over 20%. Two Pseudomonas aeruginosa strains resistant to all the 6 drugs were identified in January 2004, and till June 2005, totally 18 panresistant strains had been isolated with dramatic increases in MIC value. In the clinical two-drug regimen, sulbactam/amikacin, sulbactam/ciprofloxacin, tazobactam/amikacin, and imipenem/amikacin still had low resistant rates. CONCLUSIONS: Multi-drug resistance of Pseudomonas aeruginosa to the antibiotics is a serious problem. A two-drug regimen based on anti-microbial susceptibility test should be chosen.
Assuntos
Farmacorresistência Bacteriana Múltipla , Pseudomonas aeruginosa/efeitos dos fármacos , Amicacina/administração & dosagem , Amicacina/farmacologia , Ciprofloxacina/administração & dosagem , Ciprofloxacina/farmacologia , Quimioterapia Combinada , Humanos , Testes de Sensibilidade Microbiana , Ácido Penicilânico/administração & dosagem , Ácido Penicilânico/análogos & derivados , Ácido Penicilânico/farmacologia , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa/isolamento & purificação , Sulbactam/administração & dosagem , Sulbactam/farmacologia , TazobactamRESUMO
A clinical analysis of hyperthyroidism heart diseases was conducted in 31 elderly patients, of whom 15 (48.4%) had been misdiagnosed before accurate diagnoses were reached 4 months to 3 years later. Among the 15 misdiagnosed cases, 9 were misdiagnosed as coronary heart disease, 3 as pulmonary heart disease, 2 as hypertension heart disease and 1 as dilated cardiomyopathy. This result suggests that physicians need to be more aware of elderly hyperthyroidism, and thorough history inquiry, systemic examination and timely thyroid function test can reduce the misdiagnosis of hyperthyroid heart disease in elderly patients.
