RESUMO
A visible-light-induced cycloaddition between 2-alkenylarylisocyanides and cyclopropylanilines is reported. This cascade radical reaction constructs two new C-C bonds and two rings to afford 3-aminotetrahydro-1H-carbazols with high atom and step economy. The mechanism is rationalized as involving sequential distonic radical cation formation/isocyanide insertion/5-exo-trig cyclization/intramolecular iminium ion addition/tautomerization.
RESUMO
A cationic hydrolytical-polycarboxybetaine (HPCB), poly(N-ethyl acetate-4-vinylpyridinium bromide) was synthesized by incorporating ester group into the side chain of polycarboxybetaine (PCB). The hydrolytic behaviors of HPCB samples in pH 7.4 phosphate buffer saline (PBS) were investigated by FT-IR and (1)H NMR. The layer-by-layer (LbL) assembly of HPCB/poly (sodium 4-styrenesulfonate) PSS and the disintegration of HPCB/PSS multilayer films were monitored by UV-vis absorption spectroscopy, quartz crystal microbalance (QCM) and atomic force microscopy (AFM). The disintegrated behavior of multilayer films was studied in detail by changing the cationic degree of HPCB and the pH of the immersion solution (PBS) in the disintegration process. The disintegration time of HPCB/PSS multilayer films could be controlled widely from 2 min to 30 days in PBS.
