The transition characteristics and driving mechanisms of rural residential land in metropolitan areas-a case study of Tianjin, China.

Rural revitalization is the core decision for eradicating global poverty and achieving shared prosperity, and one of the most important works is to optimize and manage rural land space. A theoretical framework based on urbanization theory was built to reveal the rural residential land transition in the Tianjin metropolitan area, China from 1990 to 2020. The transition features are identified by computing the land-use conversion matrix and the rural residential land expansion index (RRLEI) and the influencing factors and mechanisms through a multiple linear regression model. The spatial distribution of rural residential land shows that it expands from the inner suburbs to the outer suburbs, then diminishes in the outer suburbs, and extends to the Binhai New Area. Low-level conflicts between rural residential land and urban construction land occurred during the rapid urbanization period, resulting in disorganized and wasteful growth. The inner suburbs have edge-expansion, dispersion, and urban encroachment patterns; the outer suburbs have edge-expansion, infilling, and dispersion patterns, with little urban encroachment; and Binhai New Area has just an edge-expansion pattern. During decelerated urbanization stage, a high-level conflict occurred between rural residential land and arable land, forestland, grassland, water, and urban construction land. Dispersion grew as urban encroachment reduced in the inner suburbs; dispersion increased while urban encroachment declined in the outer suburbs; dispersion, infilling expansion, and urban encroachment increased in the Binhai New Area. During the saturation stage of urbanization, rural residential land evolved in tandem with other forms of land use, with more efficient land use and diverse uses. The main pattern of rural residential land in a suburban region is still edge-expansion, dispersion has expanded in the Binhai New Area, and urban encroachment is the way of urban development in the inner suburbs. Economic factors and economic location strongly impact the dispersion pattern. Edge-expansion and infilling patterns are impacted by comparable variables, including geographical location, topography, population resources, and economic location. Furthermore, the amount of economic growth influences the edge-expansion pattern. It might be influenced by land policy, and the eight elements have no substantial relationship with urban occupancy. Based on resource endowment and pattern features, certain optimization techniques are given.

Expression, oncological and immunological characterizations of BZW1/2 in pancreatic adenocarcinoma.

Background: Despite the progress in early diagnosis and treatment, prognosis of pancreatic adenocarcinoma (PAAD) is still poor. Basic leucine zipper and W2 domain-containing protein 1 (BZW1) and protein 2 (BZW2) are attached to the basic leucine zipper (bZIP) superfamily. Recently, BZW1 was identified as an important role in glycolysis of PAAD. However, the comprehensive reports about BZW1/2 in PAAD are not sufficient. Methods: RNA-seq data in the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were retrospectively analyzed. We explored the expression of BZW1/2 in PAAD tissues and the associations between BZW1/2 and prognosis. In addition, the potential roles of BZW1/2 in tumor microenvironment (TME) of PAAD were analyzed. Finally, clinicopathological data of 49 patients with PAAD in our institution were collected. Immunohistochemistry was used to determine the expression of BZW1/2 in PAAD samples. Results: BZW1 and BZW2 were upregulated in PAAD tissues compared to normal tissues (p < 0.05). The expression of BZW1/2 were not significantly correlated with gender, grade and stage of PAAD (p > 0.05). High expression of BZW2 was an independent predictor for poor prognosis of PAAD (HR 1.834, 95%CI 1.303-2.581, p = 0.001). And a nomogram to predict overall survival (OS) of PAAD was established with a C-index of 0.685. BZW1 and BZW2 expression were positively associated with T cell mediated immune response to tumor cell and Th2 cells in xCell database. Tumor Immune Single-Cell Hub (TISCH) analyses indicated that BZW1 and BZW2 were mainly expressed in B cells and malignant cells. External cohort furtherly validated that high expression of BZW1 and BZW2 were predictors for poor prognosis of PAAD. Conclusion: We found that BZW1 and BZW2 are highly expressed in malignant cells and B cells in the TME of PAAD. BZW2 is an independent predictor for OS of PAAD. BZW1 and BZW2 expression are positively associated with T cell mediated immune response to tumor cell and Th2 cells in PAAD.

Assessment of the spatio-temporal pattern of PM2.5 and its driving factors using a land use regression model in Beijing, China.

With the acceleration of urbanization and industrialization, atmospheric pollution has become a major issue, restricting the sustainable development of the urban environment. Since 2013, Beijing has been among China's most seriously affected regions in terms of haze pollution. Atmospheric pollution is closely linked to land use, particularly the spatial patterns of green and urban land. Therefore, the quantification of the relationship between fine particulate matter (PM2.5) concentration and its driving factors in Beijing is of considerable significance for environmental management and spatial epidemiological studies. A land use regression (LUR) model was constructed to simulate the spatio-temporal distribution of PM2.5 concentration. In this study, the independent variables (driving factors) included land use, meteorological factors, population, roads, the digital elevation model, and the normalized difference vegetation index. The five models had adjusted R2 of 0.887, 0.770, 0.742, 0.877, and 0.798, respectively. Land use and meteorological factors were the main factors affecting PM2.5 concentration. The driving factors of land use on a large scale and roads on a small scale had a significant impact on PM2.5 emissions. Beijing's PM2.5 concentrations in 2015 showed clear spatio-temporal characteristics. The highest (lowest) average PM2.5 concentration was recorded in winter (summer). In terms of spatial distribution, PM2.5 concentrations showed a "low in the northwest and high in the southeast" trend. The most polluted areas were mainly distributed in the central city and the southeastern and southwestern regions. The PM2.5 concentration boundary was essentially consistent with the boundary of land use type. Different land use types promoted or inhibited PM2.5 concentrations, with a difference of more than 20 µg/m3 PM2.5 between the two land use categories. Thus, PM2.5 concentrations should be controlled by optimizing the spatial and temporal patterns of land use.

Spatial-temporal characteristics of China's industrial wastewater discharge at different scales.

Industrial wastewater is one of the three industrial wastes. If substandard industrial wastewater is discharged into the environment, there will be a serious impact on the environmental quality. Excessive emissions also indicate that water resources utilization is unreasonable. Therefore, it is of great significance to study the changing trends and influencing factors of industrial wastewater discharge in order to effectively conserve resources and improve the environmental quality. In this study, the spatial autocorrelation and the environmental Kuznets curve were used to study the spatial-temporal changes and characteristics of industrial wastewater discharge at the provincial scale and prefectural scale in China in 2004-2015. Then, the Logarithmic Mean Divisia Index was used to analyze the influencing factors of wastewater discharge in this period. China's total industrial wastewater discharge showed a trend of increasing at the beginning and then decreasing, and more than half provinces or cities show this trend of decoupling from economic development. Moreover, wastewater discharge was higher in the east region and lower in the west region at both the provincial scale and prefectural scale, but the aggregation degree on the prefectural scale is more obvious than that on the provincial scale. The technical effect has a general inhibitory effect on industrial wastewater discharge, but it also promoted the discharge in a few cities; the structure effect on industrial wastewater discharge has generally changed from promotion to inhibition during the study period; and economic effect and population effect were mainly to promote industrial wastewater discharge. Therefore, a few cities should accelerate technology upgrading and industrial restructuring in recent years in order to change the promoting effect, and most cities need to strengthen the implementation of economic measures and improve the residents' environmental awareness.

Estimating the potential of energy saving and carbon emission mitigation of cassava-based fuel ethanol using life cycle assessment coupled with a biogeochemical process model.

Global warming and increasing concentration of atmospheric greenhouse gas (GHG) have prompted considerable interest in the potential role of energy plant biomass. Cassava-based fuel ethanol is one of the most important bioenergy and has attracted much attention in both developed and developing countries. However, the development of cassava-based fuel ethanol is still faced with many uncertainties, including raw material supply, net energy potential, and carbon emission mitigation potential. Thus, an accurate estimation of these issues is urgently needed. This study provides an approach to estimate energy saving and carbon emission mitigation potentials of cassava-based fuel ethanol through LCA (life cycle assessment) coupled with a biogeochemical process model-GEPIC (GIS-based environmental policy integrated climate) model. The results indicate that the total potential of cassava yield on marginal land in China is 52.51 million t; the energy ratio value varies from 0.07 to 1.44, and the net energy surplus of cassava-based fuel ethanol in China is 92,920.58 million MJ. The total carbon emission mitigation from cassava-based fuel ethanol in China is 4593.89 million kgC. Guangxi, Guangdong, and Fujian are identified as target regions for large-scale development of cassava-based fuel ethanol industry. These results can provide an operational approach and fundamental data for scientific research and energy planning.

SHCBP1 is a novel target and exhibits tumor­promoting effects in gastric cancer.

The present study investigated the expression and potential influence of SHC SH2 domain­binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in GC tissues. Furthermore, SHCBP1 was revealed to be highly expressed in GC cell lines MGC­803 and SGC­7901 cells, and downregulation of SHCBP1 significantly inhibited GC cell proliferation. Furthermore, SHCBP1 expression promoted cell cycle progression and inhibition of apoptosis. Since the CDK4, cyclin D1 and caspase family proteins play important roles in cell cycle and apoptosis regulation, it was examined whether there was an association between SHCBP1 and these signaling pathways in GC. Our results revealed that SHCBP1 promoted cell cycle progression by regulating the CDK4­cyclin D1 cascade and suppressed caspase­3, caspase PARP­dependent apoptotic pathways. Cell invasion and metastasis experiments also revealed that SHCBP1 promoted tumor growth and invasiveness. These tumor­promoting functions of SHCBP1 may provide a potential molecular basis for the diagnosis and targeted therapy of GC.

Laparoscopic splenectomy: posterolateral approach in patients with liver cirrhosis and portal hypertension with platelet count lower than 1 × 109/l.

INTRODUCTION: Laparoscopic splenectomy for massive splenomegaly secondary to liver cirrhosis and portal hypertension in patients with an extremely low platelet count (< 1 × 109/l) presents several challenges. The posterolateral laparoscopic splenectomy approach may be a feasible and safe technique for these patients. AIM: To evaluate the feasibility and safety of the posterolateral laparoscopic splenectomy approach in patients with platelet counts < 1 × 109/l secondary to liver cirrhosis and portal hypertension. MATERIAL AND METHODS: In the period from January 2013 to December 2016, 11 patients with platelet counts < 1 × 109/l secondary to liver cirrhosis and portal hypertension underwent posterolateral laparoscopic splenectomy in our institution. Pre-, peri-, and postoperative medical managements were reviewed retrospectively. RESULTS: Patients' median platelet count was 0.7 × 109/l at the time of inpatient admission. The median operating time was 75 min, and the median intraoperative blood loss was 30 ml. One patient underwent intraoperative transfusion. The median duration of postoperative hospital stay was 5 days. No intra- or postoperative complications ensued, all patients were followed for 12-32 months (median: 24 months), and none had postoperative complications. CONCLUSIONS: The posterolateral laparoscopic splenectomy approach is a feasible, safe technique in the treatment of patients with platelet counts < 1 × 109/l secondary to liver cirrhosis and portal hypertension.

Splenic Bed Laparoscopic Splenectomy Approach for Massive Splenomegaly Secondary to Portal Hypertension and Liver Cirrhosis.

This study was performed to evaluate the feasibility of the splenic bed laparoscopic splenectomy approach (SBLS) for massive splenomegaly (≥30 cm) in patients with hypersplenism secondary to portal hypertension and liver cirrhosis. Patients who underwent laparoscopic splenectomy (LS) from January 2012 to December 2016 were retrospectively reviewed. We performed LS in 83 patients with massive splenomegaly (≥30 cm) secondary to portal hypertension and liver cirrhosis. Of these patients, 37 underwent the SBLS and 46 underwent anterior LS (ALS). Five patients in the ALS group and none in the SBLS group underwent conversion to open surgery. The operation time, intraoperative blood loss volume, transfusion volume, frequency of transfusion, hemorrhage of short gastric vessels, conversion rate, postoperative hospital stay, and incidence of pancreatic fistula were all significantly lower in the SBLS than ALS group (all P < 0.05). No death or postoperative bleeding occurred in the two groups, and there were no significant differences in age, gender, spleen size, hemoglobin level, platelet count, prothrombin time, Child-Pugh class, hypoproteinemia, or ascites (all P > 0.05). The SBLS is more feasible and effective than ALS in patients with massive splenomegaly (≥30 cm) secondary to portal hypertension and liver cirrhosis.

The spatio-temporal dynamic pattern of rural domestic solid waste discharge of China and its challenges.

At present, construction of rural domestic waste treatment facilities is seriously lagging, and in many cases, treatment facilities do not yet exist in some villages of China. Serious rural waste pollution has not only impacted the quality of surface water and groundwater but also the atmosphere and the living environment of farmers of China. There are relatively few studies of rural domestic waste pollution, especially with respect to the spatio-temporal dynamic pattern of rural domestic waste discharge. Using survey data and income per capita, we calculated rural domestic waste discharge per capita per day. From this, we calculated provincial rural domestic waste discharge. According to our study, rural domestic waste discharge was 1.42 × 108 t/year in 2000. This number increased to 2.3 × 108 t/year in 2006 and to 2.47 × 108 t/year in 2010. Rural domestic waste increased dramatically while the actual rural population and the proportion of the rural population declined. When examining the eight regions, the rural domestic waste discharge of northeastern China, Qinghai-Tibet, middle China, and southwestern China had increased dramatically, while that of northern China, southern China, and eastern China increased relatively slowly. The economies of northern China, southern China, and eastern China are more developed; their rural domestic waste discharge has been high since 2000 and has continued to increase slowly. In northeastern China, Qinghai-Tibet, middle China, and southwestern China, rural domestic waste discharge was low in 2000; however, in the ten-year period from 2000 to 2010, their rural domestic waste discharge increased dramatically.

Assessing summertime urban warming and the cooling efficacy of adaptation strategy in the Chengdu-Chongqing metropolitan region of China.

Western China has experienced rapid urbanization since the Chinese reform process began in the late 1970s. It is essential to study the spatiotemporal patterns of warming induced by historical and future urban expansion and to evaluate adaptation strategies for the Chengdu-Chongqing metropolitan region (CCMR) in western China. The observed urban heat island intensity was ~1.5K in July 2009-2011. We employed the weather research and forecasting (WRF) model using real and projected urban land-use data to simulate near-surface air temperatures for a crop, urban in 2010 and urban in 2030 scenarios in summer over the CCMR. The difference between urban 2010 and cropland scenarios is 0.93K. Warming induced by urban development in 2010-2030 is in the range of 1-1.5K, but warming induced by future urban development will be less intense than historical warming over eastern China. We increased roof albedo to 0.8 to assess the difference in near-surface air temperature between cool roofs (CR) and urban 2030 scenarios, which represents the maximum potential impact of CR; we also assessed the cooling caused by green roofs (GR) (i.e., the difference between the GR and urban 2030 scenarios). Greater cooling occurs during the day due to reflection of solar radiation by CR and additional water evaporation by GR. We provided an evaluation criterion, cooling efficiency (CE), to measure the local performances of CR and GR. CE represents the local cooling capability based on urban warming rather than absolute cooling over a larger spatial scale. CE reveals a lower nocturnal cooling capability, which poses a significant challenge to the applications of CR and GR at night. CR has a better cooling capability across CCMR than GR, only when roof albedo of CR exceeds 0.68. Measures enacted should be appropriately adjusted to optimize for cost, technology and energy savings.

USLE-Based Assessment of Soil Erosion by Water in the Nyabarongo River Catchment, Rwanda.

Soil erosion has become a serious problem in recent decades due to unhalted trends of unsustainable land use practices. Assessment of soil erosion is a prominent tool in planning and conservation of soil and water resource ecosystems. The Universal Soil Loss Equation (USLE) was applied to Nyabarongo River Catchment that drains about 8413.75 km² (33%) of the total Rwanda coverage and a small part of the Southern Uganda (about 64.50 km²) using Geographic Information Systems (GIS) and Remote Sensing technologies. The estimated total annual actual soil loss was approximately estimated at 409 million tons with a mean erosion rate of 490 t·ha(-1)·y(-1) (i.e., 32.67 mm·y(-1)). The cropland that occupied 74.85% of the total catchment presented a mean erosion rate of 618 t·ha(-1)·y(-1) (i.e., 41.20 mm·y(-1)) and was responsible for 95.8% of total annual soil loss. Emergency soil erosion control is required with a priority accorded to cropland area of 173,244 ha, which is extremely exposed to actual soil erosion rate of 2222 t·ha(-1)·y(-1) (i.e., 148.13 mm·y(-1)) and contributed to 96.2% of the total extreme soil loss in the catchment. According to this study, terracing cultivation method could reduce the current erosion rate in cropland areas by about 78%. Therefore, the present study suggests the catchment management by constructing check dams, terracing, agroforestry and reforestation of highly exposed areas as suitable measures for erosion and water pollution control within the Nyabarongo River Catchment and in other regions facing the same problems.

Cadmium (Cd) distribution and contamination in Chinese paddy soils on national scale.

Rice is a staple food by an increasing number of people in China. As more issues have arisen in China due to rice contaminated by cadmium (Cd), Cd contamination in arable soils has become a severe problem. In China, many studies have examined Cd contamination in arable soils on a national scale, but little studies have focused on the distribution of Cd in paddy fields. This study explored the spatial pattern of Cd in paddy soils in China, made a preliminary evaluation of the potential risk, and identified the most critically contaminated regions based on the domestic rough rice trade flow. The results showed that Cd concentrations in paddy soils in China ranged from 0.01 to 5.50 mg/kg, with a median value of 0.23 mg/kg. On average, the highest Cd concentrations were in Hunan (0.73 mg/kg), Guangxi (0.70 mg/kg), and Sichuan (0.46 mg/kg) provinces. Cd concentrations in paddy soils in central and western regions were higher than those in eastern regions, especially the southeastern coastal regions. Of the administrative regions, Cd standard exceedance rate was 33.2 %, and the heavy pollution rate was 8.6 %. Regarding to Cd of paddy soil, soil environmental quality was better in Northeast China Plain than in Yangtze River Basin and southeastern coastal region. Mining activities were the main anthropogenic pollution source of Cd in Chinese paddy soil. Based on rice trade, more of the Chinese population would be exposed to Cd through intake of rice produced in Hunan province. Certain regions that output rice, especially Hunan province, should be given priority in the management and control of Cd contamination in paddy soil.

Laparoscopic Liver Resection can be an Effective Way in Obese Patients: A Single Center of 2-Year Experience.

OBJECTIVE: To evaluate the feasibility and safety of laparoscopic liver resection in obese patients, we compared the operative outcomes between obese and nonobese patients, also between laparoscopic liver resection and open liver resection of obese and nonobese patients. MATERIALS AND METHODS: A total of 86 patients suffering from liver resection in our department from January 2013 to December 2014 were divided into 3 groups: the obese patients group for laparoscopic liver resection, the nonobese patients group for laparoscopic liver resection and the obese patients group for open liver resection. Characteristics and clinic data of 3 groups were studied. RESULTS: Characteristics of patients and clinic data were equivalent between the 3 groups. The groups were well matched in age, sex distribution, and liver function (P>0.05). There were no significant differences in the operative time, estimated blood loss, time to oral intake, and postoperative hospital stay in the 3 groups. Tumor diameter of laparoscopic liver resection groups in obese patients was smaller than open liver resections groups in obese patients (P<0.05), but there were no obvious difference of tumor diameter in the laparoscopic liver resection groups of the obese patients and the nonobese patients. CONCLUSIONS: Obesity should not be seen as a contraindication for laparoscopic liver resection, which is a safe and feasible procedure for obese patients.

YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells.

The expression of Yes-associated protein (YAP) has been reported to be dysregulated in pancreatic cancer. However, its contributions to tumor formation and progression remain to be elucidated. The present study demonstrated that YAP overexpression promoted the epithelial­mesenchymal transition (EMT) in a manner associated with pancreatic cancer invasion in vitro. RNA interference­mediated silencing of YAP attenuated cell invasion in vitro. Mechanistically, the present study demonstrated that YAP overexpression fosters pancreatic cancer progression by inducing the EMT in pancreatic cancer cells by activating the AKT cascade, which can counteract the effect of gemcitabine. These data suggested that the YAP acts synergistically to promote pancreatic cancer progression by hyperactivation of AKT signaling. The present study revealed YAP as a potential therapeutic target for pancreatic cancer and a biomarker for predicting gemcitabine treatment response.

Laparoscopic Versus Open Resection for Liver Cavernous Hemangioma: A Single Center of 2-Year Experience.

OBJECTIVE: To evaluate the feasibility and safety of laparoscopic versus open resection for liver cavernous hemangioma (LCH). MATERIALS AND METHODS: A total of 131 patients suffering from LCH operated in our department between January 2013 and December 2014 were divided into 2 groups: 31 for laparoscopic liver resection (LR) and 100 for open liver resection (OR). RESULTS: Age, sex, presence or absence of chronic liver disease, tumor size, tumor location, type of resection, estimated intraoperative blood loss, operative time, length of postoperative hospital stay, morbidity, and mortality were equivalent between the 2 groups. There were no significant differences in estimated intraoperative blood loss between the LR and OR groups. The operation time of the LR group was longer than the OR group and the hospitalization expenses less than the OR group. However, the time of postoperative hospital stay and time of oral intake were shorter in the LR group than the OR group. The tumor of the LR group was smaller than the OR group. In liver function, alanine aminotransferase after operation of the LR group was lower than the OR group, the same as aspartate transaminase after operation. But there were no significant differences in total bilirubin after operation. CONCLUSIONS: Laparoscopic resection for LCH is a safe and feasible procedure as OR.

Characteristics of particulate matter (PM10) and its relationship with meteorological factors during 2001-2012 in Beijing.

Atmospheric pollution has become a significant challenge in Beijing metropolitan region, China. In this study, wavelet analysis and gray analysis were proposed to explore the temporal characteristics of particulate matter (PM10) and its relationships with meteorological factors during 2001-2012. The analysis indicated that air quality had got better significantly over the last decade. It was clearly interannual, seasonal, and monthly variation of atmospheric pollution, which represented that the air quality was the worst in spring, and got better in summer, subsequently tended to be more serious in autumn and winter. Generally atmospheric pressure was the most important meteorological feature influencing on PM10, followed by relative humidity and wind speed. However, the dominant meteorological factors influencing the atmospheric pollution were different in the four seasons. The results suggest that urban design and effective measures based on the relationship between meteorological factors and PM10 would be effective for improving atmospheric pollution.

Assessing the impact of the urbanization process on net primary productivity in China in 1989-2000.

Urban development affects the material circulation and energy flow of ecosystems, thereby affecting the Net Primary Productivity (NPP). The loss of NPP due to urban expansion was calculated integrating GLO-PEM with remote sensing and GIS techniques in China during the period of 1989-2000. Using urban expansion and the mean NPP for the different land use types in the fourteen regions, the total loss of NPP was calculated as 0.95 Tg C, which accounted for 0.03% of the national NPP of 1989. The total loss of NPP due to the transformation from cropland to urban land accounted for 91.93%, followed by forest (7.17%) and grassland (0.69%). However, the conversion from unused land, industrial and construction land, and water bodies to urban land resulted in an increase in the NPP. The regions locating in eastern China and middle China had large reductions in the total NPP due to urban expansion.

The spatio-temporal dynamic pattern of rural residential land in China in the 1990s using Landsat TM images and GIS.

Through interpreting Landsat TM images, this study analyzes the spatial distribution of rural settlements in China in 2000. It calculates rural residential land percentage for every 1-km(2) cell. The entire country is divided into 33 regions to investigate the spatio-temporal dynamic patterns of rural residential land during the 1990s. According to the remote sensing survey, the rural residential land increased by 7.88 x 10(5) ha in the 1990s. The increment of rural residential land was 0.55 million ha in 1990-1995 and 0.23 million ha in 1995-2000. In 1990-1995, rural residential land increased dramatically in the eastern regions such as the Yangtze River Delta, Pearl River Delta, and North China Plain, accounting for 80.80% of the national growth; the expansion in the western regions was much more moderate. In 1995-2000, the expansion of rural residential land in eastern regions slowed, accounting for only 58.54% of the increase at the national level, whereas the expansion in the western regions accelerated. Rapid rural residential development resulted from increasing home construction and the limited control on rural land. The great regional disparity reflected the regional economic development and land-use policy change. Our finding shows that nearly 60% of the rural residential area came from cropland.