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1.
Int J Biol Macromol ; 269(Pt 1): 132107, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38710246

RESUMO

Soft assembly of peptide and curcumin (Cur) molecules enables functional integration by finding dynamic equilibrium states through non-covalent interactions. Herein, we developed two soft assembly systems, curcumin-egg white peptides (Cur-EWP) aggregations (AGs) and Cur-EWP-casein-quaternary chitosan (Cur-EWP-CA-QC) nanoparticles (NPs) to comparatively investigate their therapeutic effects on ulcerative colitis in mice and elucidate their underlying mechanism. Results revealed that Cur-EWP AGs, despite gastrointestinal tract instability, exhibited a propensity for swift accumulation within the colorectal region, enriching mucus-associated and short-chain fatty acid (SCAF)-producing bacteria, restoring the intestinal barrier damage. Whereas, Cur-EWP-CA-QC NPs, benefiting from their remarkable stability and exceptional mucosal adsorption properties, not only enhanced permeability of Cur and EWP in the small intestine to activate the immune response and boost tight junction protein expression but also, in their unabsorbed state, regulated the intestinal flora, exerting potent anti-inflammatory activity. Soft assembly of peptides and hydrophobic nutraceuticals could synergize biological activities to modulate chronic diseases.


Assuntos
Caseínas , Quitosana , Colite Ulcerativa , Curcumina , Curcumina/farmacologia , Curcumina/química , Quitosana/química , Quitosana/farmacologia , Colite Ulcerativa/tratamento farmacológico , Colite Ulcerativa/metabolismo , Animais , Camundongos , Caseínas/química , Caseínas/farmacologia , Nanopartículas/química , Peptídeos/farmacologia , Peptídeos/química , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/química , Masculino , Microbioma Gastrointestinal/efeitos dos fármacos , Clara de Ovo/química , Mucosa Intestinal/metabolismo , Mucosa Intestinal/efeitos dos fármacos
2.
World J Surg Oncol ; 19(1): 282, 2021 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-34537060

RESUMO

OBJECTIVE: To explore the clinical outcomes and effect on intraoperative blood loss and postoperative pain of patients undergoing the retroperitoneal laparoscopic partial nephrectomy (RLPN) for complex renal tumors. METHODS: Fifty patients with complex renal tumor admitted to our hospital from February 2017 to February 2019 were selected as the research object and divided into the RLPN group (given the retroperitoneal laparoscopic partial nephrectomy, n = 24) and the OPN group (given the open partial nephrectomy, n = 26) by number table method to compare their various perioperative indicators and serum stress response and analyze the clinical effect of different surgical methods on the complex renal tumor. RESULTS: The clinical information of patients in both groups were not significantly different (P > 0.05); in addition to the operative time, the intraoperative blood loss, hospital stay, warm ischemia time, and numerical rating scale (NRS) scores of the RLPN group were clearly lower than those of the OPN group (P < 0.05); after treatment, patients in the RLPN group obtained significantly lower white blood cell (WBC) count, cortisol, and c-reactive protein (CRP) levels than the OPN group (P < 0.05); the renal glomerular filtration rate (GFR) of the affected side, quality of life scores, and 3-year overall survival rate of treated patients in the RLPN group were obviously higher than those in the OPN group (P < 0.05); and patients in the RPLN group had significantly lower incidence rate (P < 0.05). CONCLUSION: Compared with OPN, RLPN is more worthy of promotion and application, because it has better treatment outcomes, significantly reduces intraoperative blood loss, alleviates the body stress response and postoperative pain, and improves the quality of life.


Assuntos
Neoplasias Renais , Laparoscopia , Perda Sanguínea Cirúrgica , Humanos , Neoplasias Renais/cirurgia , Nefrectomia/efeitos adversos , Dor Pós-Operatória/etiologia , Complicações Pós-Operatórias , Prognóstico , Qualidade de Vida
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