Generalized single index modeling of longitudinal data with multiple binary responses.

In health and clinical research, medical indices (eg, BMI) are commonly used for monitoring and/or predicting health outcomes of interest. While single-index modeling can be used to construct such indices, methods to use single-index models for analyzing longitudinal data with multiple correlated binary responses are underdeveloped, although there are abundant applications with such data (eg, prediction of multiple medical conditions based on longitudinally observed disease risk factors). This article aims to fill the gap by proposing a generalized single-index model that can incorporate multiple single indices and mixed effects for describing observed longitudinal data of multiple binary responses. Compared to the existing methods focusing on constructing marginal models for each response, the proposed method can make use of the correlation information in the observed data about different responses when estimating different single indices for predicting response variables. Estimation of the proposed model is achieved by using a local linear kernel smoothing procedure, together with methods designed specifically for estimating single-index models and traditional methods for estimating generalized linear mixed models. Numerical studies show that the proposed method is effective in various cases considered. It is also demonstrated using a dataset from the English Longitudinal Study of Aging project.

Information content of stepped wedge designs under the working independence assumption.

The stepped wedge design is increasingly popular in pragmatic trials and implementation science research studies for evaluating system-level interventions that are perceived to be beneficial to patient populations. An important step in planning a stepped wedge design is to understand the efficiency of the treatment effect estimator and hence the power of the study. We develop several novel analytical results for designing stepped wedge cluster randomized trials analyzed through generalized estimating equations under a misspecified working independence correlation structure. We first contribute a general variance expression of the treatment effect estimator when data collection is scheduled for each cluster-period. Because resource and patient-centered considerations may intentionally call for an incomplete design with outcome data being omitted for certain cluster-periods, we further derive the information content based on the robust sandwich variance to identify data elements that may be preferentially omitted with minimum loss of precision in estimating the treatment effect. We prove that centrosymmetric pairs of cluster-periods, treatment sequences and periods have identical information content and thus contribute equally to the treatment effect estimation, as long as the true covariance structure for the cluster-period means remains centrosymmetric. Finally, we provide an example of how to obtain an incomplete stepped wedge design that admits a more efficient independence GEE estimator but requires less data collection effort. Our results elegantly extend existing ones from linear mixed models coupled with model-based variances to accommodate a misspecified independence working correlation structure through the robust sandwich variances.

Multivariate single index modeling of longitudinal data with multiple responses.

In medical studies, composite indices and/or scores are routinely used for predicting medical conditions of patients. These indices are usually developed from observed data of certain disease risk factors, and it has been demonstrated in the literature that single index models can provide a powerful tool for this purpose. In practice, the observed data of disease risk factors are often longitudinal in the sense that they are collected at multiple time points for individual patients, and there are often multiple aspects of a patient's medical condition that are of our concern. However, most existing single-index models are developed for cases with independent data and a single response variable, which are inappropriate for the problem just described in which within-subject observations are usually correlated and there are multiple mutually correlated response variables involved. This paper aims to fill this methodological gap by developing a single index model for analyzing longitudinal data with multiple responses. Both theoretical and numerical justifications show that the proposed new method provides an effective solution to the related research problem. It is also demonstrated using a dataset from the English Longitudinal Study of Aging.

Impact of unequal cluster sizes for GEE analyses of stepped wedge cluster randomized trials with binary outcomes.

The stepped wedge (SW) design is a type of unidirectional crossover design where cluster units switch from control to intervention condition at different prespecified time points. While a convention in study planning is to assume the cluster-period sizes are identical, SW cluster randomized trials (SW-CRTs) involving repeated cross-sectional designs frequently have unequal cluster-period sizes, which can impact the efficiency of the treatment effect estimator. In this paper, we provide a comprehensive investigation of the efficiency impact of unequal cluster sizes for generalized estimating equation analyses of SW-CRTs, with a focus on binary outcomes as in the Washington State Expedited Partner Therapy trial. Several major distinctions between our work and existing work include the following: (i) we consider multilevel correlation structures in marginal models with binary outcomes; (ii) we study the implications of both the between-cluster and within-cluster imbalances in sizes; and (iii) we provide a comparison between the independence working correlation versus the true working correlation and detail the consequences of ignoring correlation estimation in SW-CRTs with unequal cluster sizes. We conclude that the working independence assumption can lead to substantial efficiency loss and a large sample size regardless of cluster-period size variability in SW-CRTs, and recommend accounting for correlations in the analysis. To improve study planning, we additionally provide a computationally efficient search algorithm to estimate the sample size in SW-CRTs accounting for unequal cluster-period sizes, and conclude by illustrating the proposed approach in the context of the Washington State study.