Distraction as a simple and effective method to reduce pain during local anesthesia: A randomized controlled trial.

BACKGROUND: The administration of local anesthetics is considered the most unpleasant part of office-based surgery. Many procedural and pharmacological strategies have been developed to minimize pain. In children and adolescents, distraction has been demonstrated to be an effective way of minimizing pain during local anesthesia. We present a randomized controlled trial of the effect of distraction on pain during local anesthesia in adults. MATERIAL AND METHODS: We have included 115 patients undergoing small office-based surgery to either the face, wrist, or hand. We randomized these patients between two groups: a control group and an intervention group. The intervention group watched a distractive video during the administration of the local anesthetic; for the rest the surgical procedures were performed in an equal fashion in both groups. Preoperative anxiety was scored from 0 to 10 and pain experienced during the injection of local anesthetic was measured on the visual analogue scale of pain (VAS), ranging from 0 to 10. Patient satisfaction was measured on the Patient Satisfaction Questionnaire (PSQ-18), ranging from 18 to 90. RESULTS: Patients had an equal anticipated pain score in control and intervention group. In the intervention group, a reduction of pain scores of 1 point was observed (p = 0.01). There was no difference in patient satisfaction scores between both groups. DISCUSSION: In this study, we demonstrate the pain minimizing effect of distraction during the administration of local anesthesia. Less experienced pain did not result in improved patient satisfaction in our study. We encourage physicians to seek ways to actively distract patients during unpleasant procedures.

[Sunburn of a reconstructed breast: risk of denervated tissue]. / Zonverbranding van een gereconstrueerde borst.

More and more women opt for breast reconstruction with autologous tissue after breast removal. Reconstruction with a deep inferior epigastric perforator (DIEP) flap is the most common technique. In this operation, the nerves of the DIEP flap are cut. This creates a denervated reconstructed breast which is not only numb, but also lacks autonomic response. This makes the tissue more susceptible to thermal injury. We present a case of a 66-year-old woman who underwent uncomplicated breast reconstruction with a DIEP flap 8 months ago. She recently noticed a second-degree burn on her reconstructed breast after she had been sitting in the sun whilst dressed. She did not feel anything and noticed it by accident. Familiarity with this phenomenon is important for all parties involved in care and aftercare of breast cancer and breast reconstruction, so adequate information can be provided. Reinnervation of the reconstructed breast could be a solution, but more research is needed.

Distinct defects in collagen microarchitecture underlie vessel-wall failure in advanced abdominal aneurysms and aneurysms in Marfan syndrome.

An aneurysm of the aorta is a common pathology characterized by segmental weakening of the artery. Although it is generally accepted that the vessel-wall weakening is caused by an impaired collagen metabolism, a clear association has been demonstrated only for rare syndromes such as the vascular type Ehlers-Danlos syndrome. Here we show that vessel-wall failure in growing aneurysms of patients who have aortic abdominal aneurysm (AAA) or Marfan syndrome is not related to a collagen defect at the molecular level. On the contrary our findings indicate similar (Marfan) or even higher collagen concentrations (AAA) and increased collagen cross-linking in the aneurysms. Using 3D confocal imaging we show that the two conditions are associated with profound defects in collagen microarchitecture. Reconstructions of normal vessel wall show that adventitial collagen fibers are organized in a loose braiding of collagen ribbons. These ribbons encage the vessel, allowing the vessel to dilate easily but preventing overstretching. AAA and aneurysms in Marfan syndrome show dramatically altered collagen architectures with loss of the collagen knitting. Evaluations of the functional characteristics by atomic force microscopy showed that the wall has lost its ability to stretch easily and revealed a second defect: although vascular collagen in normal aortic wall behaves as a coherent network, in AAA and Marfan tissues it does not. As result, mechanical forces loaded on individual fibers are not distributed over the tissue. These studies demonstrate that the mechanical properties of tissue are strongly influenced by collagen microarchitecture and that perturbations in the collagen networks may lead to mechanical failure.