[Effect of luliberin in the treatment of mental disorders in cerebral arteriosclerosis]. / Effekty liuliberina v lechenii psikhicheskikh narushenii pri tserebral'nom ateroskleroze.

The article presents the results of investigation into hypothalamic-hypophyseal-adrenal system in cerebral atherosclerosis leading to mental disorders. A hypothesis was put forward assuming a major role of luliberins in the pathogenesis of these disorders. Reported are the data on practical application of luliberin in the therapy of mental disorders in cerebral atherosclerosis. Clinical observations and inferences were confirmed in biochemical studies.

[The range of potential practical use for luliberin as a neurotropic peptide]. / Diapazon vozmozhnogo prakticheskogo primeneniia liuliberina kak neirotropnogo peptida.

Some aspects of the effect of LH-RH on behavior reactions and CNS activity were investigated. LH-RH was shown to produce a positive effect on teaching processes in animals, to possess analgesic and antispasmodic activity, and to activate the central nervous system. The adaptogenic properties of LH-RH necessitated a study of its potential to stop dysadaptation.

[Differentiated therapy of the sequelae of craniocerebral injuries using neuropeptides]. / Differentsirovannaia terapiia posledstvii cherepno-mozgovoi travmy neiropeptidami.

A course of neuropeptide hormones (vasopressin and corticotropin) administration is offered to treat patients with head trauma. The therapeutic effectiveness has been evidenced by the physiologic and laboratory investigations. The lack of counterindications and complications after the neuropeptides administration constitute the main advantages of the method.

[Psychotropic properties of corticotropin and its analogs]. / Psikhotropnye svoistva kortikotropina i ego analogov.

The authors presented evidence for the effect of 6 analogues of ACTN4-10 on teaching of albino rats in a labyrinth with negative electrocutaneous reinforcement. Sixteen series of experiments on 192 rats demonstrated a positive effect of corticotropin fragments on memory processes. The activating ACTH fragment effect was shown in recording the background and bioelectrically induced rabbit brain activity in response to a photo-flash in 36 experiments on 18 animals. Three groups of 30 patients with alcohol withdrawal syndrome, posttraumatic craniocerebral effect and schizophrenia received injections of corticotropin as a therapeutic agent. A high efficacy of corticotropin in the treatment of the alcohol withdrawal syndrome and after effect of craniocerebral injury and a low efficacy and sometimes aggravation of symptoms in schizophrenia patients were shown.

[Neuropeptides in the treatment of alcoholism and alcoholic psychoses]. / Neiropeptidy v terapii alkogolizma i alkogol'nykh psikhozov.

The intranasal administration of the hypothalamic peptide hormones vasopressin and corticotropin was used in the therapy of alcohol abstinence syndrome, acute and chronic alcoholic psychoses and in the conditioned reflex therapy of alcoholism. The proposed methods of therapy were fairly effective and free of complications and marked side effects.

[Psychotropic properties of oxytocin]. / Psikhotropnye svoistva oksitotsina.

Oxytocin neurotropic qualities were investigated in "reserpine depression" tests under ethanol and levomepromazine anesthesia, phenamine depression, haloperidol catatonia and swimming of experimental animals in the cylinder. Twenty seven patients with schizophrenia were treated with the hormone mentioned, injected intravenously and/or intranasally, using a double blind control test. The activating psychotropic oxytocin effects were revealed, allowing one to utilize it as a therapeutic means for psychosis treatment.

[Use of vasopressin the treatment of the paranoid form of schizophrenia]. / Primenenie vazopressina v terapii bol'nykh paranoidnoi formoi shizofrenii.

Forty-seven males suffering from paranoid schizophrenia running a paroxysm-like progressive course were treated with the synthetic neuropeptide arginine-vasopressin, a hormone of the posterior lobe of the hypophysis. The therapeutic effect of the hormone was confirmed by a complex of clinical, laboratory and pathopsychological techniques. Both objective methods of investigation and subjective assessment of the patients demonstrated a high efficacy of the drug which was expressed in a marked psychoenergizing action, a beneficial effect on emotional disorders, a memory improvement and a favourable influence on the apatho-abulic manifestations.