[Changes in the coagulation status of patients with chronic obstructive lung disease following the electrophoretic use of heparin]. / Promeni v koagulatsionniia status pri bolni s khronichna obstruktivna belodrobna bolest sled elektroforetichno prilagane na kheparin.

49 patients with chronic obstructive pulmonary disease and 40 healthy persons were examined. The hemocoagulation state indices were followed up before and after treatment. The patients with chronic obstructive pulmonary disease were classified into two groups: I gr.--treated without drugs acting on the hemocoagulation factors, II gr.--treated with heparin applied by electrophoresis. Significant changes of some of the basic indices of hemostasis were found. Following electrophoretic application of heparin they were considerably improved compared with the control group of patients treated without heparin. This kind of treatment is well tolerated by the patients and does not lead to untoward reactions.

[Anticoagulants and changes in the coagulation status of patients with chronic obstructive lung disease and various degrees of respiratory failure]. / Antikoagulanti i promeni v koagulatsionniia status pri bolni s khronichna obstruktivna belodrobna bolest i razlichna stepen na dikhatelna nedostatuchnost.

The study includes 94 persons: 54 patients with chronic obstructive pulmonary disease and 40 healthy controls. The coagulation indices were followed up dynamically before and after heparin treatment. The patients with chronic obstructive pulmonary disease were classified into 3 groups in relation to the degree of respiratory failure. The results show significant changes in some of the basic hemostatic indices: decreased antithrombin III activity, increased alpha 2-macroglobulin and plasminogen activity, partial thromboplastin time shortening, increased erythrocyte, hemoglobin and hematocrit values. With deterioration of the respiratory failure these changes become more manifested which increases significantly the risk of pulmonary thromboembolism. The values of platelets, fibrinogen, prothrombin time, bleeding time, clotting time, alpha 2-antiplasmin and prekallikrein activity do not show any significant changes and are not reliable indices for hemostatic changes in patients with chronic obstructive pulmonary disease. The administration of heparin improves the changed basic indices. This is best expressed in patients with III degree respiratory failure. The parameters of external respiration and gas exchange improve parallelly with the improvement of the coagulation state.

[Experiments to elucidate the role of Aspergillus fungi in the hemorrhagic syndrome in poultry]. / Opiti za iziasniavane roliata na gubichki ot rod Aspergillus za khemoragichniia sindrom pri ptitsi.

Attempts were made to assess the role played by fungi of the Aspergillus genus in the occurrence of the hemorrhagic syndrome in birds. Groups of test birds were given continuously a forage mixture containing 30 per cent of ground nut cake which had aflatoxin at the rate of 1.5 ppm, a forage mixture 30 per cent of which was preliminarily contaminated with spores of Asp. fumigatus or Asp. flavus, and subtoxic amounts of nonpurified aflatoxin. Growth retardation was established along with the development of slightly manifested morphologic changes in some organs of the test birds. No morphologic picture characteristic of a hemorrhagic syndrome was found. In the authors' opinion the toxic Aspergillus fungi entering the body of the birds via the forage were not the sole factor contributing to the outbreak of such a syndrome.

[Parasitic fusaria in corn an attempts to isolate phytoestrogens from them]. / Parazitni fuzarii po tsarevitsata i opiti za izolirane na fitoestrogeni ot tiakh.

A total of 123 fungus strains of the Fusarium genus were found in 181 samples of maize. Fusarium moniliforme was most frequently isolated. It was found that 14 of the strains produced F-2 toxin. Experiments were carried out with 50 male and female guinea pigs. Each of the test animals was given orally 0.2 ml (daily, in the course of twenty days) crude toxin obtained through growing the fungus--selected strains--on sterile maize flour. It was established that most of the tested toxins affected the reproductive apparatus of the animals, causing necrobiotic and degenerative changes. Some Furarium species even produced toxic substances that manifested tropism to the digestive tract, liver, kidneys, heart, the nervous system, where they caused hemodynamic troubles and degenerative changes.