Effective intravenous cyclosporin therapy in a patient with severe Crohn's disease on parenteral nutrition.

We report a patient with severe Crohn's disease and the short bowel syndrome on parenteral feeding who was not responding to conventional therapy and underwent treatment with cyclosporin (CyA) given initially intravenously and subsequently orally in each of two courses. Plasma drug concentrations were largely kept within the therapeutic range but wide variability was observed on oral therapy. Improvement both clinically and by objective assessment, was observed on intravenous CyA therapy, but was not sustained when the drug was given orally for several months. None of the side effects observed resisted treatment or was severe enough to warrant discontinuation of therapy. These findings suggest that there may be a place for intravenous CyA therapy in patients with severe Crohn's disease who do not respond to conventional therapy or to oral treatment with CyA.

Eastern geothermal resources: should we pursue them?

A geothermal resource that consists of hot water at moderate temperatures (below 125 degrees C) underlies many areas in the central and eastern United States. Programs funded by the Department of Energy have revealed that this resource is definable and economically competitive with conventional fuels for use in direct heat applications. The resource, therefore, has the potential for reducing our dependence on the imported oil used for space heating. However, front-end costs and risks to explore, drill, test, and evaluate the magnitude of the resource have inhibited development. The question is, therefore, how much federal stimulation will be needed to convince private capital to exploit this widespread low-quality energy source.

Early meteorological results from the viking 2 lander.

Early results from the meteorological instruments on the Viking 2 lander are presented. As on lander 1, the daily patterns of temperature, wind, and pressure have been highly repetitive during the early summer period. The average daily maximum temperature was 241 degrees K and the diurnal minimum was 191 degrees K. The wind has a vector mean of 0.7 meter per second from the southeast with a diurnal amplitude of 3 meters per second. Pressure exhibits both diurnal and semidiurnal oscillations, although of substantially smaller amplitude than those of lander 1. Departures from the repetitive diurnal patterns begin to appear on sol 37.

Mars climatology from viking 1 after 20 sols.

The results from the meteorology instruments on the Viking 1 lander are presented for the first 20 sols of operation. The daily patterns of temperature, wind, and pressure have been highly consistent during the period. Hence, these have been assembled into 20-sol composites and analyzed harmonically. Maximum temperature was 241.8 degrees K and minimum 187.2 degrees K. The composite wind vector has a mean diurnal magnitude of 2.4 meters per second with prevailing wind from the south and counterclockwise diurnal rotation. Pressure exhibits diurnal and semidiurnal oscillations. The diurnal is ascribed to a combination of effects, and the semidiurnal appears to be the solar semidiurnal tide. Similarities to Earth are discussed. A major finding is a continual secular decrease in diurnal mean pressure. This is ascribed to carbon dioxide deposition at the south polar cap.

Preliminary meteorological results on Mars from the viking 1 lander.

The results from the meteorology instruments on the Viking 1 lander are presented for the first 4 sols of operation. The instruments are working satisfactorily. Temperatures fluctuated from a low of 188 degrees K to an estimated maximum of 244 degrees K. The mean pressure is 7.65 millibars with a diurnal variation of amplitude 0.1 millibar. Wind speeds averaged over several minutes have ranged from essentially calm to 9 meters per second. Wind directions have exhibited a remarkable regularity which may be associated with nocturnal downslope winds and gravitational oscillations, or to tidal effects of the diurnal pressure wave, or to both.