[Light-chain plasmacytoma with reversible renal insufficiency after intravascular application of thorotrast (author's transl)]. / Leichtkettenplasmozytom mit reversibler Niereninsuffizienz nach intravasaler Thorotrastanwendung.

Thirty-three years after intravascular injection of Thorotrast, a light-chain plasmacytoma with hypercalcemia and renal insufficiency was diagnosed in a 60-year-old man. The question of causal relation between Thorotrast deposit and plasmacytoma is discussed. The accumulated radiation load to the bone-marrow as caused by thorium dioxide deposition amounts to circa 3000 rem. According to casuistic and epidemiological communications, induction of plasmacytomas by external X-irradiation may be regarded as possible. A distinct increase in myeloproliferative diseases but only small numbers of plasmacytomas are reported in extensive epidemiological Thorotrast studies. From combination of results of the three most comprehensive epidemiological Thorotrast studies is obtained a numerical ratio of 1:5 for the spontaneous rate against the number of plasmacytomas observed. Identical correlations are yielded by investigations at Hiroshima and Nagasaki. Hence it is to be supposed that also plasmacytomas can be induced by thorotrastosis of the reticulohistiocytic system.

[Folic acid substitution in hemodialyzed patients. Folic acid levels in plasma and erythrocytes]. / Folsäure-Substitution bei Hämodialyse-Patienten. Untersuchungen zum Fols-5aaure-Spiegal in Plasma und Erthrozyten

Investigations of folic acid levels in plasma and erythrocytes. In 20 patients on hemodialysis with and without folic acid substitution the concentration of folic acid in plasma and in red cells was estimated by radioassay. In patients, who were substituted with folic acid concomitantly with elevated folic acid concentrations hematocrit values were higher than those of patients who were not substituted. Folic acid concentrations in patients not substituted. Folic acid concentrations in patients not substituted were subnormal and further decreased on dialysis. Results of folic acid determinations in plasma were paralleled by concentrations in erythrocytes. It is concluded, that folic acid substitution is necessary in patients on hemodialysis.

[Proceedings: Plasma hemoglobin in patients with intermittent hemodialysis with special reference to various dialysis procedures]. / Hämoglobin im Plasma bei Dauerhämodialyse-Patienten unter Berücksichtigung verschiedener Dialyseverfahren

In the pathogenesis of anemia in patients on intermittent hemodialysis is a frequently mentioned factor. To evaluate the red blood cell trauma caused by the hemodialyser, free hemoglobin was determined in the plasma before and after various types of hemodialysis. We investigated 22 patients with chronic renal failure in the age range from 18 to 54 years who were hemodialysed with various types of shunt (Cimino, Scribner or Thomas shunt) and hemodialysers (Kiil or Rhone-Poulenc). Determinations of hemoglobin in the plasma before and after 8-h hemodialysis were performed by the method of RICHTERICH. A significant increase in the initial normal values for hemoglobin in the plasma were found, but without any correlation between rate of hemolysis and type of hemodialyser. The presumed mechanical destruction of erythrocytes during hemodialysis can be determined by the free hemoglobin in the plasma. The small extent of intravascular hemolysis does not correlate with the type of hemodialyser.