RESUMO
Twenty-one SNPs located in the cluster of genes FMO1-FMO2-FMO3-FMO4 and adjacent areas were analyzed in the patients with ischaemic cardioembolic stroke and in the control group. Significant differences between these samples were found in the distribution of genotype and allele differences in two polymorphic loci, rs10912745 and rs4916375. It was shown that these polymorphic loci are associated with the risk of ischaemic cardioembolic stroke development.
Assuntos
Doenças Cardiovasculares/genética , Isquemia/genética , Oxigenases/genética , Acidente Vascular Cerebral/genética , Feminino , Estudos de Associação Genética , Humanos , Família Multigênica/genética , Polimorfismo de Nucleotídeo Único , Fatores de RiscoRESUMO
The analysis of association between DNA markers and total stroke risk was performed in 950 Slavonic patients. Patients with cardioembolic stroke were selected for a genome-wide association study. The HUMANCYTOSNP12 v.2 microchip was used to analyze all DNA samples on a panel of 301 000 single nucleotide polymorphisms. SNP rs1842993 on chromosome 7 was found to be associated with cardioembolic stroke risk.
Assuntos
Centrômero/genética , Cromossomos Humanos Par 7/genética , Acidente Vascular Cerebral/etnologia , Acidente Vascular Cerebral/genética , Idoso , Idoso de 80 Anos ou mais , DNA/genética , Embolia/complicações , Feminino , Marcadores Genéticos , Cardiopatias/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Análise de Sequência com Séries de Oligonucleotídeos , População Branca/genéticaRESUMO
We studied SNP41 (rs152312) and SNP87 (rs2910829) of the PDE4D gene in 577 stroke patients and 270 healthy controls. The significant differences in the distribution of genotype and allele frequencies of the SNP41 between patients and controls were revealed. Genotypes AA and AG were associated with the higher risk of stroke in the Moscow population (OR 1,6). No association between SNP87 and stroke was found.
