RESUMO
Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964-2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16-79%) per 1,000 kJ/m(2)/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0-19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
Assuntos
Influenza Humana/complicações , Leucemia/epidemiologia , Leucemia/etiologia , Estações do Ano , Luz Solar , Doença Aguda , Finlândia/epidemiologia , Humanos , Incidência , Leucemia Mieloide Aguda/epidemiologia , Leucemia Mieloide Aguda/etiologia , Deficiência de Vitamina D/complicaçõesRESUMO
Valproic acid (VPA), an inhibitor of histone deacetylases, inhibits the growth of leukemia cells and induces their differentiation in vitro. In the present study, VPA in combination with two differentiating agents, 13-cis retinoic acid and 1,25-dihydroxyvitamin D3, was given to 19 previously untreated patients with MDS or CMML. Eight patients had to discontinue treatment before week 16 due to toxicity. According to international working group criteria, three patients (16%) responded to treatment. No correlation between VPA serum level, histone acetylation or clinical response was observed.
Assuntos
Calcitriol/uso terapêutico , Isotretinoína/uso terapêutico , Síndromes Mielodisplásicas/tratamento farmacológico , Ácido Valproico/uso terapêutico , Acetilação/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Calcitriol/administração & dosagem , Calcitriol/efeitos adversos , Queilite/induzido quimicamente , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Quimioterapia Combinada , Fadiga/induzido quimicamente , Histonas/metabolismo , Humanos , Isotretinoína/administração & dosagem , Isotretinoína/efeitos adversos , Pessoa de Meia-Idade , Pneumonia/induzido quimicamente , Processamento de Proteína Pós-Traducional/efeitos dos fármacos , Resultado do Tratamento , Ácido Valproico/administração & dosagem , Ácido Valproico/efeitos adversosAssuntos
Doença de Gaucher/genética , Doença de Gaucher/terapia , Predisposição Genética para Doença , Glucosilceramidase/uso terapêutico , Saposinas/genética , Desenvolvimento Infantil/fisiologia , Pré-Escolar , Feminino , Seguimentos , Doença de Gaucher/diagnóstico , Doença de Gaucher/epidemiologia , Glucosilceramidase/deficiência , Humanos , Incidência , Lactente , Masculino , Medição de Risco , Índice de Gravidade de DoençaRESUMO
In this study, the course of 40 pregnancies in 16 women with essential thrombocythaemia (ET) was analysed retrospectively. Of the pregnancies, 45% were complicated, 55% uncomplicated, and 62% resulted in live birth. The most common complication was spontaneous abortion during the first trimester seen in 33% of all pregnancies and comprising 72% of all complications. Two intrauterine foetal deaths occurred at weeks 22 and 28. Three pregnancies were complicated by eclampsia or pre-eclampsia. Nine of 16 women with 29 pregnancies had at least one complicated pregnancy. In seven of 16 women, all 11 pregnancies were uneventful. The non-pregnancy-related symptoms of ET or the platelet count before conception or during pregnancy did not correlate with the risk of pregnancy complications. Treatment with low-dose acetylsalicylic acid (ASA) alone during pregnancy or platelet-lowering drugs before or during pregnancy reduced the risk of complications.