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Exp Biol Med (Maywood) ; 244(9): 734-742, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31042071

RESUMO

IMPACT STATEMENT: The mechanism of gastric cancer is highly complex, accompanied by a variety of genetic abnormalities. It is of great significance to elucidate the pathogenesis of gastric cancer, find its markers and therapeutic targets in the fight against this fatal disease. In this study, we identified P2RX7 as a putative target of gastric cancer, which was overexpressed in gastric cancer tissues and had relationship with worse prognosis. We also elucidated the roles of P2RX7 on the growth and metastasis of gastric cancer cells, and explored the relationship between it and ERK1/2 pathway, Akt pathway, and epithelial-mesenchymal transition. Our findings begin to offer useful insights into the mechanism of gastric cancer progression and provide clues to novel therapy strategies.


Assuntos
Receptores Purinérgicos P2X7/metabolismo , Neoplasias Gástricas/diagnóstico , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/metabolismo , Western Blotting , Linhagem Celular Tumoral , Feminino , Humanos , Estimativa de Kaplan-Meier , Sistema de Sinalização das MAP Quinases , Masculino , Pessoa de Meia-Idade , Prognóstico , Reação em Cadeia da Polimerase em Tempo Real , Receptores Purinérgicos P2X7/análise , Estômago/química , Neoplasias Gástricas/química , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/mortalidade , Análise de Sobrevida
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