RESUMO
As an educational exercise with real-world application, a standard motor go-kart was altered so that a person with disabilities could control it with one hand via a joystick. The first step was to establish the exact design requirements. Then the power systems to operate the steering, throttle, and brakes were selected and the analog control circuits and amplifiers to drive and control the power systems were built. Finally, the mechanisms to connect the power systems to the various functions on the go-kart were designed and built. The complete system was then tested with a group of children with disabilities, and problems with the system were identified.
Assuntos
Pessoas com Deficiência/reabilitação , Jogos e Brinquedos , Tecnologia Assistiva , Criança , Eletrônica , Desenho de Equipamento , Segurança de Equipamentos , HumanosRESUMO
Fluorouracil is given for a variety of neoplasms by various administrative routes. Toxicity of susceptible normal tissue limits systemic dosage, but at this level intraocular tissue may not receive tumor-inhibiting concentrations. Subconjunctival administration of 6.25 mg of 14C-fluorouracil in 0.5-mL dosages resulted in a peak anterior chamber concentration of 69.5 micrograms/mL and a peak vitreous concentration of 10.5 micrograms/mL over the 12 hours tested. This resulted in no visible ocular damage. The intraocular levels achieved were greater than the concentration reported to inhibit selected tumors. The total dosage administered was considerably below the level of systemic toxicity.
