[Prognostic study of cell proliferative markers ki67, PCNA and p53 oncoprotein in bladder tumors]. / Etude pronostique des marqueurs de prolifération Ki67 et PCNA et de l'oncoprotéine p53 dans les tumeurs vésicales.

We report a study of cell proliferative factors Ki67, PCNA and p53 oncoprotein in 55 patients with bladder tumors. Fifty-three of the patients were male and two were female, with a mean age of 56.6 and 68.5 years, respectively. These tumors were of transitional cell type in 97.9% of the cases. Staging was, respectively, pTis (4.76%), pTa (30.9%), pT1 (19.04%), pT2 (23.8%) and Pt3 (21.4%). Our study of proliferative nuclear markers Ki67 showed that cell proliferation increased in bladder tumors according to grade in the same stage. This variation was highlighted by our results for PCNA but was not verified for Ki67. However, these results revealed an increase of cell proliferation for a same grade (grade I and II) in different stages (pTa, pT1, pT2) for PCNA; this was not ascertained for Ki67. The study of p53 oncoprotein showed that detection of mutated p53 protein increased according to grade only for grades II and III and to stage only when moving from pTis to superficial tumors (pTa, pT1) and to deep tumors (pT2, pT3), thus individualizing two groups without significant variation within these groups. A variation according to grade in the same stage was noted only for stages pT1 and pT2. A variation for a same grade (grades II and III) was reported between stages pTa, pT1 and pT2. The combined study of Ki67, PCNA and p53 oncoprotein showed a prognostic correlation between these three markers in general.

[Extra-adrenal gland pheochromocytoma. Apropos of 3 cases and review of the literature]. / Le phéochromocytome extrasurrénalien. A propos de trois observations et revue de la littérature.

The authors report three new cases of ectopic pheochromocytoma: latero-aortic, bladder and near the kidney. From the review of the literature, they propose a diagnostic and therapeutic strategy for the management of ectopic localisation of pheochromocytoma.

[Bladder pheochromocytoma and pregnancy. A case report]. / Phéochromocytome vésical et grossesse. Une observation.

The authors report the case of a 31-year old patient who successfully completed a pregnancy despite unsuspected bladder pheochromocytoma. After delivery, the patient required care post-partum due to serious hemodynamic problems. Hypertension had been attributed to toxemia of pregnancy. The authors recall the diagnostic difficulties of tumors of this type, and the means which can be used for topographical diagnosis and the precautions to be taken before this tumor can be treated surgically.

[A case of bladder pheochromocytoma]. / A propos d'une observation de phéochromocytome vésical.

Phaeochromocytoma is an endocrine neuroectodermal tumour usually located in the adrenal gland, but occasionally arising in other organs. The authors report a case of a vesical phaeochromocytoma presenting with haematuria. Radiological and endoscopic investigations revealed a right laterovesical submucosal tumour. Partial cystectomy was performed. The normality of the postoperative endocrine survey suggested disappearance of the tumour and absence of any other sites.

[Disease of the pyelo-ureteral junction in adults. 215 cases in 194 patients]. / La maladie de la jonction pyélo-urétérale chez l'adulte. 215 cas chez 194 malades.

215 uretero-pelvic obstruction syndrome among 194 adult patients are analysed. 56.8% of them are of stage III or IV. Lithiasis is a frequent complication (41.8% of cases). The other congenital anomalies are very rare. The diagnosis is based on intravenous pyelography with use of furosemide test when the obstruction is moderate. 178 uretero-pelvic plasties are performed, the resection-anastomosis has retrained our choice. It was done in 119 cases with good results in 85.6 cases. Failure are due to error of indication or technical defect. The high level of nephrectomies (25%) is explained by the very important number of advanced and complicated cases. Among the less symptomatic patients, 37 haven't been operated on and were controlled. All except one remained stable.