Assuntos
Neoplasias Esofágicas , Melanoma , Transtornos de Deglutição/etiologia , Transtornos de Deglutição/fisiopatologia , Progressão da Doença , Endossonografia/métodos , Neoplasias Esofágicas/patologia , Neoplasias Esofágicas/fisiopatologia , Neoplasias Esofágicas/cirurgia , Esofagectomia/efeitos adversos , Esofagectomia/métodos , Evolução Fatal , Humanos , Masculino , Melanoma/patologia , Melanoma/fisiopatologia , Melanoma/cirurgia , Pessoa de Meia-Idade , Terapia Neoadjuvante/métodos , Estadiamento de Neoplasias , Reoperação/efeitos adversos , Reoperação/métodosRESUMO
Malignant peritoneal effusions often arise in patients with ovarian carcinoma. They are a hazardous complication of cancer. Systematic intraperitoneal chemotherapy is not necessarily followed by long-term remission and may even induce untoward side effects. Intraperitoneal interleukin-2 (IL-2) and IL-2/lymphokine-activated killers (LAK) biotherapy showed high efficacy in treatment of ovarian carcinoma patients suffering from peritoneal effusions. The objective effect was 80.1% and 82.6%, respectively. Our results suggest that intraperitoneal biotherapy may be extended to dealing with malignant peritoneal effusions in ovarian carcinoma.
Assuntos
Antineoplásicos/administração & dosagem , Líquido Ascítico/efeitos dos fármacos , Terapia Biológica/métodos , Interleucina-2/administração & dosagem , Células Matadoras Ativadas por Linfocina , Neoplasias Epiteliais e Glandulares/terapia , Neoplasias Ovarianas/terapia , Adulto , Idoso , Líquido Ascítico/patologia , Carcinoma Epitelial do Ovário , Feminino , Humanos , Infusões Parenterais , Pessoa de Meia-Idade , Neoplasias Epiteliais e Glandulares/tratamento farmacológico , Neoplasias Epiteliais e Glandulares/patologia , Neoplasias Ovarianas/tratamento farmacológico , Neoplasias Ovarianas/patologia , Resultado do TratamentoRESUMO
We studied the possibility of using coal hemosorbents for elimination gram-positive and gram-negative microorganisms from the blood. After hemosorption, the number of S. aureus and K. pneumoniae pneumoniae colony-forming units significantly decreased. The obtained results indicate that coal sorbents can bind and probably eliminate gram-positive and gram-negative bacteria from the blood.
Assuntos
Carvão Mineral , Hemofiltração/métodos , Klebsiella pneumoniae/isolamento & purificação , Staphylococcus aureus/isolamento & purificação , Bacteriemia/sangue , Bacteriemia/microbiologia , Bacteriemia/terapia , Humanos , Klebsiella pneumoniae/crescimento & desenvolvimento , Staphylococcus aureus/crescimento & desenvolvimentoRESUMO
Clinical efficiency of low dose Roncoleukin was studied in 30 patients with metastatic exudative pleurisy. Intrapleural therapy proved to be highly effective (overall effect reached 84%), was well tolerated, and improved patients' quality of life.
Assuntos
Interleucina-2/uso terapêutico , Neoplasias , Pleurisia , Adulto , Idoso , Feminino , Humanos , Imunofenotipagem , Injeções Intralesionais , Interleucina-2/administração & dosagem , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/patologia , Pleurisia/tratamento farmacológico , Pleurisia/etiologia , Resultado do TratamentoRESUMO
To analyze the functions of lymphokine-activated killer cells (LAKC) and to study their phenotype are of paramount importance in the assessment of their role in antitumor immunity. The natural killers--hepatic T cells--have been shown to be used to prepare LAKS that have a higher cytotoxic activity than LAKS that are generalized from peripheral mononuclear cells.
Assuntos
Células Matadoras Ativadas por Linfocina/imunologia , Células Matadoras Naturais/imunologia , Neoplasias Hepáticas/imunologia , Adolescente , Adulto , Idoso , Antígenos CD/sangue , Meios de Cultura , Testes Imunológicos de Citotoxicidade , Citotoxicidade Imunológica , Interpretação Estatística de Dados , Humanos , Imunofenotipagem , Imunoterapia Adotiva , Interleucina-2/imunologia , Leucócitos Mononucleares/imunologia , Fígado/imunologia , Neoplasias Hepáticas/sangue , Neoplasias Hepáticas/secundário , Neoplasias Hepáticas/terapia , Pessoa de Meia-Idade , Fenótipo , Linfócitos T/imunologia , Células Tumorais CultivadasRESUMO
Although there has been a sufficiently steady trend towards a decrease in the incidence of carcinoma of the stomach (CS), the problem related with treatment of this malignant tumor remains acute up to now in many countries. Presently, the surgical method, i.e. gastrectomy in the volume of D2 (with splenectomy being an element of it) remains the basic treatment for CS of stages I-III. A removal of an essential portion of the lymphoid tissues brings about a pronounced, prolonged and hard-to-correct immunodeficiency, which, in its turn, aggravates the risk of postoperative infectious complications and cuts the relapse-free life period. The method, offered by us, makes it possible to obtain the lymphocine-activated cells from the mononuclear cell population of the spleen, removed in operation, and to use them in the adoptive immunotherapy for the purpose of improving the life duration and quality for this category of patients. However, elaboration of methods combining the activation of both non-specific and specific anti-tumor immunity through designing the anti-tumor auto-vaccines based on dendrite cells is the most promising direction in the adoptive immunotherapy for a radically operated CS.
