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1.
Urologiia ; (3): 10-4, 2004.
Artigo em Russo | MEDLINE | ID: mdl-15199806

RESUMO

To evaluate prognostic value of morphometric studies of the stroma of transitional cell carcinomas of the renal pelvis and ureter, we studied retrospectively the data of primary examination and follow-up of 75 patients (49 males, 65% and 26 females, 35%; mean age 61.9 +/- 1.2 years) given radical surgical treatment for cancer of the renal pelvis and ureter. Five-year survival in the absence of tumor progression was 23%. Morphological examination diagnosed transitional cell carcinoma with invasion pT1, pT2, pT3 and pT4 in 3(4%), 15(20%), 47(63%) and 10(13%) cases and differentiation degree G1, G2, G3 in 31(41%), 15(20%) and 29(39%) cases, respectively. In addition to the standard morphological examination of the tumor, we made morphometry of stromal and tumor area, analysed composition and count of stromal effector cells (lymphocytes, eosinophilic and neutrophilic leukocytes, macrophages, mast and plasmic cells), the degree of stromal vascularization. Prognostic value of the above parameters was estimated according to significance of their correlation with postoperative survival of the patients. The survival correlated with the depth of cancer invasion (p = 0.005) and differentiation of tumor tissue (p = 0.006), high cell infiltration of tumor stroma is prognostically unfavourable (R2 = 0.03; F = 3.41; p = 0.069) as well as weak presentation of stromal component of the tumor (p = 0.056). The lowest survival was observed in patients with cancer of the renal pelvis and ureter with a great number of mast cells (p = 0.056), macrophages (p = 0.037) and neutrophils (p = 0.029) in the tumor stroma. According to the results of multiple regression analysis (R2 = 0.08; F = 5.42; p = 0.024), five-year postoperative survival most closely correlated with cancer invasion depth (p < 0.001), degree of tumor cells differentiation (p < 0.001) and number of macrophages infiltrating tumor stroma (p < 0.001). Significance of survival prognosis for patients with cancer of renal pelvis and ureter can be raised by estimation of mean number of free stromal cells and expression of stromal component.


Assuntos
Carcinoma de Células de Transição/patologia , Neoplasias Renais/patologia , Pelve Renal/patologia , Neoplasias Ureterais/patologia , Carcinoma de Células de Transição/irrigação sanguínea , Carcinoma de Células de Transição/mortalidade , Carcinoma de Células de Transição/terapia , Feminino , Humanos , Neoplasias Renais/irrigação sanguínea , Neoplasias Renais/mortalidade , Neoplasias Renais/terapia , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Prognóstico , Neoplasias Ureterais/irrigação sanguínea , Neoplasias Ureterais/mortalidade , Neoplasias Ureterais/terapia
2.
Aviakosm Ekolog Med ; 31(2): 25-7, 1997.
Artigo em Russo | MEDLINE | ID: mdl-9190250

RESUMO

Experimental verification of prostatilen prophylactics of changes in the urogenital organs consequent to g-loads was the idea of the work. The experiment was performed with 37 mongrel white male rats weighing 200-250 g who were exposed to the head-pelvis g-loads (+Gl) at 10 units. Behavior reactions of the rats were assessed with the "open field" technique immediately after centrifugation; weighing coefficients of the urogenital organs (the organ/body mass relation) were determined, and histological and morphometric analyses of prostate, testis and kidney were made. A significant moderating effect of prophylactic prostatilen on the stress-reactions in animals was first revealed; prostatilen was also found to speed up adaptation. This was concluded from normalization of the hemodynamics, a decrease in venous plethora and epithelial dystrophy, absence of basophilia in conjunctive tissue of the urogenital organs. Distention and overfilling of acini by secret and the number of epithelial acinus hulled into the lumen were markedly less in prostate. Spermatogenesis in testis was normalized, too. The histological profile of kidney approached the norm. Results of the experiment showed that prostatilen is a promising preparation from the standpoint of moderation of stress-reactions and counteraction of disorders in the urogenital organs caused by g-loads.


Assuntos
Fármacos para a Fertilidade Masculina/farmacologia , Gravitação , Peptídeos/farmacologia , Sistema Urogenital/efeitos dos fármacos , Animais , Rim/anatomia & histologia , Rim/efeitos dos fármacos , Masculino , Doenças Urogenitais Masculinas/prevenção & controle , Próstata/anatomia & histologia , Próstata/efeitos dos fármacos , Ratos , Espermatogênese/efeitos dos fármacos , Estresse Psicológico , Testículo/anatomia & histologia , Testículo/efeitos dos fármacos
3.
Patol Fiziol Eksp Ter ; (4): 36-9, 1996.
Artigo em Russo | MEDLINE | ID: mdl-9082321

RESUMO

The purpose of the present study was to examine the effects of the animal renal peptide complex renaline obtained via acid extraction on the cause of acute pyelonephritis in the experiment. Renaline was found to be highly effective in treating experimental acute pyelonephritis in rats. This is manifested as improved changes in the parameters of leukocytosis, leukocyturia, rectal temperatures, and bacteriuria along with the regression of abnormal changes and the reduction in renal mass differences, as compared to the similar parameters in untreated animals. The findings indicate that the clinical use of renaline in the combined therapy for acute pyelonephritis.


Assuntos
Pielonefrite/tratamento farmacológico , Doença Aguda , Animais , Feminino , Contagem de Leucócitos/efeitos dos fármacos , Pielonefrite/sangue , Ratos , Resultado do Tratamento
5.
Antibiotiki ; 22(6): 530-6, 1977 Jun.
Artigo em Russo | MEDLINE | ID: mdl-329749

RESUMO

Pharmacokinetics of sodium benzylpenicillin after intramuscular administration in a dose of 250 000 gamma/kg and simultaneous intramuscular injection of furosemid (lazix) in doses of 0.5--1--2 mg/kg was studied in experiments on a model of meningococcal meningitis of rabbits and in clinics on patients with meningococcal meningitis. A pronounced effect of furosemid on pharmacokinetics of benzylpenicillin as dependent on a number of factors was found. Furosemid and meningococcal endotoxin had a synergic effect and decreased benzylpenicillin excretion with urine resulting in prolongation of the antibiotic effect in the blood. An increase in benzylpenicillin blood levels and inflammation of the soft brain membranes increased permeability of the hemato-encephalic barrier for the antibiotic.


Assuntos
Barreira Hematoencefálica/efeitos dos fármacos , Furosemida/uso terapêutico , Meningite Meningocócica/tratamento farmacológico , Penicilina G/uso terapêutico , Animais , Biofarmácia , Ensaios Clínicos como Assunto , Relação Dose-Resposta a Droga , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Interações Medicamentosas , Humanos , Cinética , Penicilina G/análise , Coelhos , Fatores de Tempo
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