RESUMO
Alterations in content of lipid peroxidation products, reactions of generation/interception of superoxide anion radicals, content of R-proteins and uric acid were studied in blood serum of 83 patients with gout depending on the disease activity. Rates of lipid peroxidation, estimated by content of thiobarbituric acid-positive products, and of superoxide anion generation as well as content of R-proteins correlated distinctly with activity of the inflammation. At the same time, content of uric acid in blood serum of these patients correlated reversely with content of the lipid peroxidation products at the disease preexacerbation period, while concentration of these products depended on content of total iron.
Assuntos
Gota/sangue , Peroxidação de Lipídeos , Superóxidos/sangue , Ânions , Radicais Livres , Humanos , Transcobalaminas/metabolismo , Ácido Úrico/sangueRESUMO
An attempt was made to study the incidence of gout and hyperuricemia among the workers of the Moscow meat-packing plant exposed to high food purine loads. Using extensive clinical material (535 men and 1121 women) the authors established that gout was diagnosed 33 times more often in men of this plant than in the muscular population of other towns of the country. Moderate hyperuricemia was revealed in every second of the examinees. Marked hyperuricemia was noted 1.8 times more often, it being 3.4 times more often in men working at this plant as compared to the whole muscular population of the country. There was a direct dependence of the level of hyperuricemia in men working in this industry on their service record. The levels of moderate hyperuricemia in all groups of men and in some groups of women directly depended on the amount of daily purine loads. Marked hyperuricemia among the examined men is a factor of risk in the development of load and among the examined women an indicator of risk (i. e. warning) of possible metabolic changes which require an adequate dietetic and therapeutic correction.
