Recent Advances in Optical Fiber Enabled Radiation Sensors.

Optical fibers are being widely utilized as radiation sensors and dosimeters. Benefiting from the rapidly growing optical fiber manufacturing and material engineering, advanced optical fibers have evolved significantly by using functional structures and materials, promoting their detection accuracy and usage scenarios as radiation sensors. This paper summarizes the current development of optical fiber-based radiation sensors. The sensing principles of both extrinsic and intrinsic optical fiber radiation sensors, including radiation-induced attenuation (RIA), radiation-induced luminescence (RIL), and fiber grating wavelength shifting (RI-GWS), were analyzed. The relevant advanced fiber materials and structures, including silica glass, doped silica glasses, polymers, fluorescent and scintillator materials, were also categorized and summarized based on their characteristics. The fabrication methods of intrinsic all-fiber radiation sensors were introduced, as well. Moreover, the applicable scenarios from medical dosimetry to industrial environmental monitoring were discussed. In the end, both challenges and perspectives of fiber-based radiation sensors and fiber-shaped radiation dosimeters were presented.

Inorganic Thermoelectric Fibers: A Review of Materials, Fabrication Methods, and Applications.

Thermoelectric technology can directly harvest the waste heat into electricity, which is a promising field of green and sustainable energy. In this aspect, flexible thermoelectrics (FTE) such as wearable fabrics, smart biosensing, and biomedical electronics offer a variety of applications. Since the nanofibers are one of the important constructions of FTE, inorganic thermoelectric fibers are focused on here due to their excellent thermoelectric performance and acceptable flexibility. Additionally, measurement and microstructure characterizations for various thermoelectric fibers (Bi-Sb-Te, Ag2Te, PbTe, SnSe and NaCo2O4) made by different fabrication methods, such as electrospinning, two-step anodization process, solution-phase deposition method, focused ion beam, and self-heated 3ω method, are detailed. This review further illustrates that some techniques, such as thermal drawing method, result in high performance of fiber-based thermoelectric properties, which can emerge in wearable devices and smart electronics in the near future.

Hybrid Plasmonic Fiber-Optic Sensors.

With the increasing demand of achieving comprehensive perception in every aspect of life, optical fibers have shown great potential in various applications due to their highly-sensitive, highly-integrated, flexible and real-time sensing capabilities. Among various sensing mechanisms, plasmonics based fiber-optic sensors provide remarkable sensitivity benefiting from their outstanding plasmon-matter interaction. Therefore, surface plasmon resonance (SPR) and localized SPR (LSPR)-based hybrid fiber-optic sensors have captured intensive research attention. Conventionally, SPR- or LSPR-based hybrid fiber-optic sensors rely on the resonant electron oscillations of thin metallic films or metallic nanoparticles functionalized on fiber surfaces. Coupled with the new advances in functional nanomaterials as well as fiber structure design and fabrication in recent years, new solutions continue to emerge to further improve the fiber-optic plasmonic sensors' performances in terms of sensitivity, specificity and biocompatibility. For instance, 2D materials like graphene can enhance the surface plasmon intensity at the metallic film surface due to the plasmon-matter interaction. Two-dimensional (2D) morphology of transition metal oxides can be doped with abundant free electrons to facilitate intrinsic plasmonics in visible or near-infrared frequencies, realizing exceptional field confinement and high sensitivity detection of analyte molecules. Gold nanoparticles capped with macrocyclic supramolecules show excellent selectivity to target biomolecules and ultralow limits of detection. Moreover, specially designed microstructured optical fibers are able to achieve high birefringence that can suppress the output inaccuracy induced by polarization crosstalk and meanwhile deliver promising sensitivity. This review aims to reveal and explore the frontiers of such hybrid plasmonic fiber-optic platforms in various sensing applications.

Special Issue "Fiber Optic Sensors and Applications": An Overview.

We present here the recent advance in exploring new detection mechanisms, materials, processes, and applications of fiber optic sensors.

Carbon Allotrope-Based Optical Fibers for Environmental and Biological Sensing: A Review.

Recently, carbon allotropes have received tremendous research interest and paved a new avenue for optical fiber sensing technology. Carbon allotropes exhibit unique sensing properties such as large surface to volume ratios, biocompatibility, and they can serve as molecule enrichers. Meanwhile, optical fibers possess a high degree of surface modification versatility that enables the incorporation of carbon allotropes as the functional coating for a wide range of detection tasks. Moreover, the combination of carbon allotropes and optical fibers also yields high sensitivity and specificity to monitor target molecules in the vicinity of the nanocoating surface. In this review, the development of carbon allotropes-based optical fiber sensors is studied. The first section provides an overview of four different types of carbon allotropes, including carbon nanotubes, carbon dots, graphene, and nanodiamonds. The second section discusses the synthesis approaches used to prepare these carbon allotropes, followed by some deposition techniques to functionalize the surface of the optical fiber, and the associated sensing mechanisms. Numerous applications that have benefitted from carbon allotrope-based optical fiber sensors such as temperature, strain, volatile organic compounds and biosensing applications are reviewed and summarized. Finally, a concluding section highlighting the technological deficiencies, challenges, and suggestions to overcome them is presented.

An Integrated Sensor-Model Approach for Haptic Feedback of Flexible Endoscopic Robots.

Haptic feedback for flexible endoscopic surgical robots is challenging due to space constraints for sensors and shape-dependent force hysteresis of tendon-sheath mechanisms (TSMs). This paper proposes (1) a single-axis fiber Bragg grating (FBG)-based force sensor for a TSM of a robotic arm and (2) an integrated sensor-model approach to estimate forces on other TSMs of that arm. With a robust and simple structure, a temperature-compensated sensor can be mounted on the distal sheath to measure forces applied by the TSM. This proposed sensor was integrated with a Ø4.2 mm articulated robotic arm driven by six TSMs, with a measurement error of 0.37 N in this work. The measurement from the single sensor was used to identify parameters in the force-transmission models of all other TSMs in the robot, realizing a one-sensor-for-all-distal-forces measurement method. The sensor-model approach could accurately estimate the distal force with an RMSE of 0.65 N. An animal study was carried out to demonstrate the sensor's feasibility in real-life surgery. The sensor-model approach presented a robust, space-saving, and cost-effective solution for haptic feedback of endoscopic robots without any assumption on the shapes of the robot.

Carbon Dot-functionalized Interferometric Optical Fiber Sensor for Detection of Ferric Ions in Biological Samples.

This work reports an interferometric optical microfiber sensor functionalized with nitrogen- and sulfur-codoped carbon dots (CDs) for the detection of ferric ions (Fe3+). Compared to other CD-based ferric ion sensors, the sensing mechanism of this presented sensor is dependent on the refractive index modulations due to selective Fe3+ adsorption onto the CD binding sites at the tapered region. This is the first study in which CD-based sensing was performed at the solid phase as a chelator, which does not rely on its fluorescence properties. The detection performance of the proposed sensor is not only comparable to a conventional fluorescence-based CD nanoprobe sensor but also capable of delivering quantitative analysis results and ease of translation to a sensor device for on-site detection. The presented sensor exhibits Fe3+ detection sensitivity of 0.0061 nm/(µg/L) in the linear detection range between 0 and 300 µg/L and a detection limit of 0.77 µg/L based on the Langmuir isotherm model. Finally, the potential use of the CD-functionalized optical microfiber sensor in the real environmental and biological Fe3+ monitoring applications has also been validated in this work.

An Advanced Hand-Held Microfiber-Based Sensor for Ultrasensitive Lead Ion Detection.

This study demonstrated a l-glutathione-modified nonadiabatic microfiber sensor to detect a trace level of heavy metal ions in aqueous solution. The sensor showed an exclusively selective response to Pb2+ among other metal ions and a measured detection limit of 5 µg/L, lower than the maximum allowable limit of Pb2+ in drinking water by the World Health Organization. Moreover, a novel compact all-fiber-based interrogation scheme was proposed to promote the development of a portable hand-held system for on-site measurement. The presented scheme does not require costly and bulky laboratory equipment but operates based on the reflected optical power of two fiber Bragg gratings (FBG), measured using photodetectors independently.

Functionalized MoS2 Nanosheets as Multi-Gene Delivery Vehicles for In Vivo Pancreatic Cancer Therapy.

Transition metal dichalcogenides (TMDCs) are categorized as novel two-dimensional (2D) nanomaterials with unique physical and chemical properties, bearing varied applications in medical and materials sciences. However, only a few works report the application of TMDCs for gene therapy in cancer treatment. Here, we engineer a multi-gene delivery system based on functionalized monolayer MoS2, which can co-deliver HDAC1 and KRAS small interfering RNAs (siRNAs) to Panc-1 cancer cells for combinational cancer therapy. The synergistic effect of gene silencing therapy and NIR phototherapy is demonstrated by inhibition of both genes, in vitro cell growth rate, and in vivo tumor volume growth rate, exemplifying pre-eminent anticancer efficacy. This anti-tumor effect is a result of the photothermal effect of MoS2 induced by NIR excitation and inactivation of HDAC1 and KRAS genes, which consequently bring about apoptosis, inhibit migration, and induce cell cycle arrest in the treated Panc-1 cells. Moreover, good biocompatibility and reduced cytotoxicity of MoS2-based nanocarriers enable their metabolism within in vitro and in vivo mouse models over a prolonged duration without any evident ill-effects. In summary, we demonstrate the promising potential of low-toxicity, functionalized MoS2 nanocarriers as a biocompatible gene delivery system for in vivo pancreatic adenocarcinoma therapy.

Birefringent Bragg Grating in C-Shaped Optical Fiber as a Temperature-Insensitive Refractometer.

We demonstrate a simple-to-fabricate refractometer based on the inscription of fiber Bragg gratings in a special C-shaped optical fiber. The C-shaped fiber was drawn into shape using a quarter cladding removed preform of a commercial standard single-mode fiber by simple machining. The sensor did not suffer from cross-sensitivity of the refractive index with ambient temperature fluctuations, commonly occurring with many optical fiber refractometers. A refractive index sensitivity of 1300 pm per refractive index unit (RIU) was achieved without employing any additional sensitization techniques such as tapering or etching.

Functionalized Fiber End Superstructure Fiber Bragg Grating Refractive Index Sensor for Heavy Metal Ion Detection.

We present a novel superstructure fiber Bragg grating fiber end sensor capable of detecting variations in refractive index (RI) of liquids and potentially that of gases, and demonstrated an application in the detection of heavy metal ions in water. The sensor is capable of sensing RI variations in the range of 1.333 to 1.470 with good sensitivity of up to 230 dB/RIU achieved for the RI range of 1.370 to 1.390. The sensor is capable of simultaneously measuring variations in ambient temperature along with RI. A simple chemical coating was employed as a chelating agent for heavy metal ion detection at the fiber end to demonstrate an possible application of the sensor. The coated fiber sensor can conclusively detect the presence of heavy metal ions with concentrations upwards of 100 ppm. RI sensing capability of the sensor is neither affected by temperature nor strain and is both robust and easily reproducible.

Self-adaptive Bioinspired Hummingbird-wing Stimulated Triboelectric Nanogenerators.

Bio-inspired technologies have remarkable potential for energy harvesting from clean and sustainable energy sources. Inspired by the hummingbird-wing structure, we propose a shape-adaptive, lightweight triboelectric nanogenerator (TENG) designed to exploit the unique flutter mechanics of the hummingbird for small-scale wind energy harvesting. The flutter is confined between two surfaces for contact electrification upon oscillation. We investigate the flutter mechanics on multiple contact surfaces with several free-standing and lightweight electrification designs. The flutter driven-TENGs are deposited on simplified wing designs to match the electrical performance with variations in wind speed. The hummingbird TENG (H-TENG) device weighed 10 g, making it one of the lightest TENG harvesters in the literature. With a six TENG network, the hybrid design attained a 1.5 W m-2 peak electrical output at 7.5 m/s wind speed with an approximately linear increase in charge rate with the increased number of TENG harvesters. We demonstrate the ability of the H-TENG networks to operate Internet of Things (IoT) devices from sustainable and renewable energy sources.

A Self-Powered Implantable Drug-Delivery System Using Biokinetic Energy.

The first triboelectric-nanogenerator (TENG)-based self-powered implantable drug-delivery system is presented. Pumping flow rates from 5.3 to 40 µL min-1 under different rotating speeds of the TENG are realized. The implantable drug-delivery system can be powered with a TENG device rotated by human hand motion. Ex vivo trans-sclera drug delivery in porcine eyes is demonstrated by utilizing the biokinetic energies of human hands.

Biodegradable charged polyester-based vectors (BCPVs) as an efficient non-viral transfection nanoagent for gene knockdown of the BCR-ABL hybrid oncogene in a human chronic myeloid leukemia cell line.

First-line therapy of chronic myelogenous leukemia (CML) has always involved the use of BCR-ABL tyrosine-kinase inhibitors which is associated with an abnormal chromosome called Philadelphia chromosome. Although the overall survival rate has been improved by the current therapeutic regime, the presence of resistance has resulted in limited efficacy. In this study, an RNA interference (RNAi)-based therapeutic regime is proposed with the aim to knockdown the BCR-ABL hybrid oncogene using small interfering RNA (siRNA). The siRNA transfection rates have usually been limited due to the declining contact probability among polyplexes and the non-adherent nature of leukemic cells. Our work aims at addressing this limitation by using a biodegradable charged polyester-based vector (BCPV) as a nanocarrier for the delivery of BCR-ABL-specific siRNA to the suspension culture of a K562 CML cell line. BCR-ABL siRNAs were encapsulated in the BCPVs by electrostatic force. Cell internalization was facilitated by the BCPV and assessed by confocal microscopy and flow cytometry. The regulation of the BCR-ABL level in K562 cells as a result of RNAi was analyzed by real-time polymerase chain reaction (RT-PCR). We observed that BCPV was able to form stable nanoplexes with siRNA molecules, even in the presence of fetal bovine serum (FBS), and successfully assisted in vitro siRNA transfection in the non-adherent K562 cells. As a consequence of downregulation of BCR-ABL, BCPV-siRNA nanoplexes inhibited cell proliferation and promoted cell apoptosis. All results were compared with a commercial transfection reagent, Lipofectamine2000™, which served as a positive control. More importantly, this class of non-viral vector exhibits biodegradable features and negligible cytotoxicity, thus providing a versatile platform to deliver siRNA to non-adherent leukemia cells with high transfection efficiency by effectively overcoming extra- and intra-cellular barriers. Due to the excellent in vitro transfection results from BCPV-siRNA, a newly developed biodegradable transfection agent, BCPV, is being probed for transfection performance in an animal model.

Simultaneous measurement of curvature and strain based on fiber Bragg grating in two-dimensional waveguide array fiber.

We report on the fabrication of a fiber Bragg grating (FBG) with multiple resonances in a two-dimensional waveguide array microstructured optical fiber containing 91 cores. Theoretical investigation reveals that these resonances originate from the identical and nonidentical mode couplings between forward-propagating and backward-propagating LP0m-like (m=1, 2, 3; LP refers to linearly polarized) supermodes. Since both the central wavelength and minimum transmission of these resonant dips respond differently to curvature and axial strain, this FBG can be applied in the simultaneous measurement of curvature and axial strain.

Highly sensitive refractive index sensor based on adiabatically tapered microfiber long period gratings.

We demonstrate a refractive index sensor based on a long period grating (LPG) inscribed in a special photosensitive microfiber with double-clad profile. The fiber is tapered gradually enough to ensure the adiabaticity of the fiber taper. In other words, the resulting insertion loss is sufficiently small. The boron and germanium co-doped inner cladding makes it suitable for inscribing gratings into its tapered form. The manner of wavelength shift for refractive indices (RIs) differs from conventional LPG, and the refractive index detection limit is 1.67 × 10⁻5.

Tunable microwave generation based on a dual-wavelength single-longitudinal-mode fiber laser using a phase-shifted grating on a triangular cantilever.

Frequency tunable microwave signal generation, based on a dual-wavelength single-longitudinal-mode (SLM) erbium-doped fiber (EDF) laser, incorporating a phase-shifted fiber Bragg grating (PS-FBG) with two π-phase shifts, is demonstrated. In the proposed configuration, the PS-FBG with two ultranarrow transmission bands is embedded in a triangular cantilever to serve as a wavelength spacing tunable filter with a fixed center wavelength by applying various strains on the cantilever. A section of unpumped EDF is employed as a saturable absorber to ensure SLM operation in each of the two lasing lines. By beating the two wavelengths at a photodiode, a tunable microwave signal ranging from 8.835 to 24.360 GHz is successfully achieved.

Switchable dual-wavelength single-longitudinal-mode erbium-doped fiber laser using an inverse-Gaussian apodized fiber Bragg grating filter and a low-gain semiconductor optical amplifier.

We present a stable and switchable dual-wavelength erbium-doped fiber laser. In the ring cavity, an inverse-Gaussian apodized fiber Bragg grating serves as an ultranarrow dual-wavelength passband filter, a semiconductor optical amplifier biased in the low-gain regime reduces the gain competition of the two wavelengths, and a feedback fiber loop acts as a mode filter to guarantee a stable single-longitudinal-mode operation. Two lasing lines with a wavelength separation of approximately 0.1 nm are obtained experimentally. A microwave signal at 12.51 GHz is demonstrated by beating the dual wavelengths at a photodetector.

Refractive index sensing based on higher-order mode reflection of a microfiber Bragg grating.

A fiber Bragg grating written in a photosensitive microfiber using KrF excimer laser via a uniform phase mask is demonstrated. We have successfully fabricated two Bragg gratings in microfibers having different diameters. In the reflection spectrum of a microfiber Bragg grating (MFBG), we observed two reflection peaks,which agrees with our numerical simulation results. Compared with the fundamental mode reflection, the higher-order reflection mode is more sensitive to the refractive index (RI) variation of the surrounding fluid due to its larger evanescent field. The measured maximum sensitivity is ~102 nm/RIU (RI unit) at an RI value of 1.378 in an MFBG with a diameter of 6 µm.

Simultaneous strain and temperature measurement using a compact photonic crystal fiber inter-modal interferometer and a fiber Bragg grating.

An all-fiber sensor scheme for simultaneous strain and temperature measurement is presented. The sensing head is formed by serially connecting a polarization maintaining photonic-crystal-fiber-based inter-modal interferometer (IMI) with a fiber Bragg grating (FBG). The IMI, exhibiting an opposite strain response as compared to that of the FBG, is highly sensitive to strain, while it is insensitive to temperature. This has potential for improving the strain and temperature measurement resolutions. A sensor resolution of ±8.3 µÎµ in strain and ±2 °C in temperature are experimentally achieved within a strain range of 0-957.6 µÎµ and a temperature range of 24 °C-64 °C, respectively.