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Probl Endokrinol (Mosk) ; 26(4): 69-72, 1980.
Artigo em Russo | MEDLINE | ID: mdl-7413616

RESUMO

Experiments were conducted on rats with prolonged (6-9 months) alloxan diabetes; a study was made of the effect of naphthylimidoacetic acid (NIAA) on the blood glucose, fructose, cholesterol and sorbitol dehydrogenase level and also on the intensity of developing microangiopathies, according to biomicroscopy of the iris and electron microscopy of the muscle capillaries. Intramuscular injection of NIAA in a dose of 50 mg/kg of body weight for 30 days failed to alter the blood sugar level, but there was a significant fall of the fructose, cholesterol, sorbitol dehydrogenase content; the intensity of microvascular affection was also considerably diminished.


Assuntos
Acetatos/uso terapêutico , Diabetes Mellitus Experimental/tratamento farmacológico , Aloxano , Animais , Capilares/efeitos dos fármacos , Angiopatias Diabéticas/prevenção & controle , Membro Posterior/irrigação sanguínea , Músculos/irrigação sanguínea , Ratos
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