[Fraxiparin as a component of lymphotropic polychemotherapy of locally spread valvular cancer in patients with chronic venous insufficiency]. / Fraksyparyn iak komponent limfotropnoï polikhimioterapiï mistsevoposhyrenoho raku vul'vy u khvorykh z khronichnoiu venoznoiu nedostatnistiu.

A total of 29 female patients with locally spread cancer of the vulva in chronic venous insufficiency underwent lymphotropic polychemotherapy. Of these, 16 subjects (55.2%) had varicosis, 13 (44.8%) presented with chronic thrombophlebitis. All above patients were found to run a high risk for development of thromboembolic complications. Administration of the thrombolytic-complication prophylaxis is exercised through the use of fraxiparin, a drug of choice. With lymphotropic polychemotherapy instituted in patients with locally spread carcinoma of the vulva and chronic venous insufficiency, fraxiparin ("Sanofi-Synthelabo") proved to be a highly effective means of prophylaxis against thromboembolic complications.

[Treatment of dystrophy, dysplasia and initial stages of vulvar carcinoma in virus infections]. / Likuvannia dystrofiï, dysplaziï ta pochatkovykh form raku vul'vy pry virusnomu infikuvanni.

Overall sixty-seven patients with distrophy, dysplasia and valvular carcinoma presenting with human papilloma virus- and herpes simplex-2 virus infections underwent a complex treatment intended for background, precancerous affections of the vulva and for valvular carcinoma, involving the use of antiviral drug preparations laferon, zovirax, lovir (both on the systemic and local basis), and an immunomodulator (decaris). Efficacy of the above treatment option has been shown to be 98.5%.

[Role of viral infection in the pathogenesis of vulvar diseases]. / Rol' virusnoï infektsiï v patohenezi zakhvoriuvan' vul'vy.

A clinical assessment was performed of results of examination in 177 patients with dystrophies, dysplasias and carcinomas of the vulva. The presence of the viral infection was ascertained on the basis of cytological signs pathognomonic for specifically viral infection. Virus infection was identified in dystrophy in 29 percent of cases, in mild displasia in 29 percent, in moderately severe in 31 percent, in severe dysplasia in 33 percent of patients. There were 80 percent of infected subjects among those with carcinomas of the vulva, which fact suggests that virus infection plays its part in the pathogenesis of the pathology in question.

[The diagnosis and treatment of background and precancerous diseases of the vulva]. / Diahnostyka ta likuvannia fonovykh i peredrakovykh zakhvoriuvan' vul'vy.

Methodological approaches have been developed toward raising the informative value of cytological diagnosis. There have been identified pathogenetic variants of background and precancerous affections of the vulva, their leading factors being viral infection, function disorders of the hypothalamic centres, hypoestrogenemia, hepatic and thyroidal abnormalities. The effectiveness of the treatment scheme developed with taking account of the above-stated items is 97.3%.