Hematosalivarian barrier: structure, functions, study methods (review of literature).

The human body consists of various systems (blood, tissues, extracellular fluid, intracellular contents) separated by biological membranes. Physiological barriers ensure the physico-chemical composition of the internal environment remains constant and protects the body from environmental changes. The permeability of the histohematic barrier depends on the concentration of substances in the blood, the body's condition, external influences, and a number of other reasons caused by stimuli coming from the external or internal environment. Information about the state of the regulatory systems of the body has its effect on specific chemoreceptors, which leads to the emergence of local and general physiological and biochemical processes. According to their localization, they distinguish between the hematoencephalic, hemato-placental, hemato-ophthalmic, and hemato-salivary barriers. Recently, the hematosalivary barrier, through which the selective entry of substances from the blood into the oral fluid is carried out, has taken a special place in the study. Its functioning depends on the processes occurring in the body, which is carried out by selective permeability for substances that determine the composition of the main internal environment of the body - blood. Hematosalivary barrier is an important link in maintaining homeostasis, which is reflected in the metabolic parameters of oral fluid.

[Evaluation of the species diversity of microflora isolated from the epithelium of the oral mucosa in patients using removable orthopedic structures based on dental implants]. / Otsenka vidovogo raznoobraziya mikroflory, vydelennoi s epiteliya slizistoi obolochki polosti rta, pri ispol'zovanii s"emnykh ortopedicheskikh konstruktsii s oporoi na dental'nye implantaty.

OBJECTIVE: To assess the species diversity of microorganisms isolated from the oral mucosa in patients with removable orthopedic structures based on dental implants. MATERIALS AND METHODS: The indicators of the species diversity of microorganisms isolated from the oral mucosa in patients of the main and control groups were studied. RESULTS: For prosthetic treatment of patients from main group we used a method of manufacturing an overlapping, frame prostheses supported by teeth and dental implants. The results turned out to be reliable for opportunistic microorganisms Streptococcus anginosus and representatives of the orange periodontopathogenic complex Streptococcus constellatus. CONCLUSION: Microbiological assessment indicates the effectiveness of prosthetic treatment and the use of Corega tablets.

Molecular profile of oral fluid in new coronavirus infection.

Oral fluid is an alternative biological material that confirms correlations with blood parameters in various pathological conditions of the body. In order to find a non-invasive approach to stratification of patients with COVID-19 disease, molecular biomarkers of the oral fluid have been determined in patients with moderate coronavirus infection in comparison with clinically healthy individuals. It has been shown that proteomic, carbohydrate, macro- and microelement profiles of the oral fluid in coronavirus infection can be used for diagnostics. The features of protein metabolism were revealed: an increase in the content of total protein, urea; increased activity of enzymes aspartate aminotransferase, gamma glutamyl transpeptidase, creatine phosphokinase, alkaline phosphatase; changes in carbohydrate metabolism, which is expressed by an increase in glucose and lactate levels, an increase in lactate dehydrogenase activity, sodium, chloride, calcium, magnesium, iron content.