1.
Org Biomol Chem
; 15(41): 8709-8712, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29039854
RESUMO
The preparation of a novel type of iminosugar including a hydrazide imide moiety is described. The sugar hydrazide imides (3S,4S,5R,6R)-1-amino-3,4,5-trihydroxy-6-(hydroxymethyl)-2-iminopiperidine acetate and (3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-imino-1-(methylamino)piperidine acetate presented here behave as inhibitors of α/ß-glucosidases in the low micromolar concentration range. The former inhibitor displays a pH-dependent inhibition of ß-glucosidase. The N-methylated counterpart behaves as an anomer-selective competitive micromolar inhibitor of α-glucosidase.