1.
Angew Chem Int Ed Engl
; 53(15): 3859-62, 2014 Apr 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24604885
RESUMO
An asymmetric synthesis of the diterpenoid 17-deoxyprovidencin is described. Key steps include an aldol addition, a base-catalyzed Wipf-type furan formation, a Z-selective ring-closing metathesis for macrocyclization, a photochemical E/Z isomerization to a highly strained and conformationally restricted ring system, and the stereoselective formation of two epoxides on the ring.