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J Rheumatol ; 37(6): 1105-12, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20436074

RESUMO

OBJECTIVE: Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a role in breaking immune tolerance to citrullinated antigens. We studied a cohort of patients with RA and their relatives looking for associations between anti-P. gingivalis antibodies and ACPA. METHODS: Patients with RA (n = 82) and their relatives (n = 205) from a North American Native (NAN) population were studied, along with 47 NAN and 60 non-NAN controls. IgM and IgA rheumatoid factor (RF) were tested by nephelometry and ELISA. Second-generation anticyclic citrullinated peptide (anti-CCP2) isotypes and IgG anti-P. gingivalis lipopolysaccharides were tested by ELISA. HLA-DRB1 typing was performed by sequencing. Oral hygiene and smoking habits were assessed by questionnaires. RESULTS: Autoantibody frequency in patients with RA and relatives: ACPA 91% vs 19%, respectively; IgM RF 82% vs 17%; IgA RF 48% vs 22%. Anti-P. gingivalis levels were higher in patients with RA compared to relatives and controls (p = 0.005) and higher in ACPA-positive patients with RA than in ACPA-negative patients with RA (p = 0.04) and relatives (p < 0.001), but comparable in RF-positive and RF-negative patients and relatives. Poor oral hygiene and smoking were prevalent, but with no clear association with autoantibodies. Relatives with 2 shared-epitope alleles were more likely to be ACPA-positive (OR 2.5, p = 0.02). CONCLUSION: In a genetically predisposed population of NAN patients with RA and their relatives, anti-P. gingivalis antibodies were associated with ACPA. These findings suggest that immune responses to P. gingivalis may be involved in breaking immune tolerance to citrullinated antigens.


Assuntos
Anticorpos Anti-Idiotípicos/imunologia , Artrite Reumatoide/imunologia , Cárie Dentária/imunologia , Peptídeos Cíclicos/imunologia , Adulto , Anticorpos Anti-Idiotípicos/sangue , Artrite Reumatoide/sangue , Artrite Reumatoide/microbiologia , Canadá/epidemiologia , Estudos de Coortes , Cárie Dentária/sangue , Cárie Dentária/microbiologia , Feminino , Humanos , Imunoglobulina A/sangue , Imunoglobulina A/imunologia , Imunoglobulina M/sangue , Imunoglobulina M/imunologia , Indígenas Norte-Americanos , Lipopolissacarídeos/imunologia , Masculino , Pessoa de Meia-Idade , Peptídeos Cíclicos/sangue , Porphyromonas gingivalis/imunologia , Porphyromonas gingivalis/isolamento & purificação , Porphyromonas gingivalis/patogenicidade , Fator Reumatoide/sangue , Fator Reumatoide/imunologia
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