RESUMO
Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from pregnancies complicated with PE and/or FGR (n = 18) and normal pregnancies (n = 17) was assessed by Affymetrix HG Focus microarray to obtain hints of mechanisms involved in the pathogenesis. A total of 200 differentially expressed transcripts were detected at a false discovery rate (FDR) Assuntos
Retardo do Crescimento Fetal/enzimologia
, Metaloproteinase 1 da Matriz/metabolismo
, Pré-Eclâmpsia/enzimologia
, Trofoblastos/metabolismo
, Decídua/metabolismo
, Feminino
, Expressão Gênica
, Perfilação da Expressão Gênica
, Humanos
, Gravidez