[The effect of periodontal cytomedin on free-radical lipid oxidation and on antiaggregation activity in the periodontium in chronic stress]. / Vliianie tsitomedina parodonta na svobodnoradikal'noe okislenie (SRO) lipidov i antiagregatsionnuiu aktivnost' v nem pri khronicheskom stresse.

Effects of polypeptide bioregulators isolated from periodontal tissue on free-radical oxidation of lipids and the microcirculatory hemostasis during the development of chronic stress were under study. Increased reactions of lipid free-radical oxidation and blood hydrocortisone levels, denudation of dental necks were observed in animals during stress, which was explained by disordered reaction of microcirculatory hemostasis assessed from the antiaggregation activity of the periodontium. Administration of a polypeptide bioregulator led to a reduction of free-radical oxidation of lipids, to an increase in the activities of antioxidative enzymes, and hence, to a reduction of the injury to the cellular structures of the periodontium due to decrease of disorders of the microcirculatory hemostasis and ischemia in it.

[The effect of periodontal cytomedin on lipid peroxidation and hemostasis in spontaneous periodontitis in rats]. / Vliianie tsitomedina parodonta na sostoianie perekisnogo okisleniia lipidov i gemostaz pri spontannom parodontite u krys.

Rats with spontaneous periodontitis develop lipid peroxidation in the blood and periodontal tissues, that is associated with hypercoagulation and fibrinolysis inhibition, reduced antiaggregation activity of the periodontal tissues. Administration of periodontal cytomedin results in normalization of lipid peroxidation, blood coagulation, and euglobulin lysis, as well as in increase in the activities of periodontal antioxidant enzymes and antiaggregation properties. Cytomedin effect on lipid peroxidation and antioxidant enzymes was more manifest in periodontal tissues than in the blood. Visual examination has shown an improvement of the periodontal tissue status, thus indicating good prospects for such therapy.

[The mechanism of the therapeutic effect of periodontal cytomedin on the course of experimental periodontitis]. / Mekhanizm terapevticheskogo éffekta tsitomedina iz parodonta na techenie éksperimental'nogo parodontita.

Periodontitis induction causes a drastic elevation of free-radical lipid peroxidation, of ceruloplasmin level, and a reduction of antioxidant enzyme activities. Blood analysis shows hypercoagulation, appearance of paracoagulation products, reduced fibrinolysis, enhanced proaggregation activity of the periodontium, elevated levels of circulating immune complexes; this may by regarded as adaptation failure manifesting by these reactions. Morphologic examinations show foci of destructive changes. Administration of periodontal cytomedin reduced the level of free-radical oxidation, enhanced the activity of antioxidant enzymes, normalized antiaggregation activity of the periodontium and hemostasis and fibrinolysis parameters, and reduced the level of circulating immune complexes. The inflammatory reaction disappears completely, that is seen from reduced ceruloplasmin level and clinically. Morphologic study shows disappearance of foci of destruction. Thus, cytomedin of periodontal tissues may be regarded as an effective agent for the therapy of experimental periodontitis.