[The experience of application of standards of laboratory diagnostic of rheumatic diseases in clinical practice.]

The article presents the results of two-year analysis of experience of application of standards of laboratory diagnostic of rheumatic diseases according data of clinical diagnostic laboratory and rheumatic department of the N.N. Burdenko Penzenskaia oblast clinical hospital. The sampling included 2363 examined patients. It was implemented 18 737 analyses i.e. in average 7.9 analyses per one patient. Out of them, tests of detection of auto antibodies consisted 42% (7871), proteins of acute phase - 13.2% (2480), intoxication syndrome - 11.2% (2098). other types of immune diagnostic - 33.6% (6288). The information markers of diagnostic, process activity, severity of course, prognosis and effectiveness of applied therapy are singled out. The conclusions about purpose and evaluation of results of laboratory studies are made.

[Complex evaluation of intestine microbiocenosis condition in patients with chronic pancreatitis].

AIM: Study the state of intestine microbiocenosis in patients with chronic pancreatitis, give comparative evaluation of diagnostic significance of bacterial and gas-liquid chromatography analysis. MATERIALS AND METHODS: 96 patients with chronic pancreatitis (CP) were examined bacteriologically for dysbacteriosis. In parallel in 42 individuals gas-liquid chromatography analysis (GLC-analysis) was carried out. RESULTS: During bacteriological examination in 93.7% of patients various dysbiotic disorders were detected. The main indicators of GLC-analysis---anaerobic index, cumulative content of volatile fatty acids and their isoforms also gave evidence on imbalance of intestine microflora. GLC-analysis as a rule confirmed the data of bacteriological examination. CONCLUSION: During parallel use ofbacteriological and gas-liquid chromatography analysis in almost all the CP patients intestine dysbacteriosis of various degree of intensity was detected. Combined use of these methods increases effectiveness of examination.

[Comparison of the results of magnetic resonance urography and other examination methods in patients with iatrogenic injuries of the ureter and pelvis-ureteral segment].

MR urography was made in 25 patients (age 24-70, mean age 48.6 years, 20 females, 5 males) with iatrogenic injury of the upper urinary tract (UUT). A comparison group consisted of 15 patients without nephrostomic drainage who had no contraindications for intravenous contrast preparations. MR urography was performed in frontal and sagittal projections. The examination was made before and 20 min after intravenous injection of 20 mg diuretic. Five patients received additionally excretory MR urography with intravenous injection of magnevist (0.2 ml/kg, 3 ml/s just before the examination). Mean duration of urography was 21 (18-23) min. The results were compared to findings of ultrasound or x-ray investigations, diapevtic ureteroscopy or open surgical intervention. The results were similar to those of x-ray CT. In patients with ureteral obliteration MR urography was less informative than joint antegrade and retrograde ureteropyelography as the ureter could not be visualized beneath the injury. In 2 patients examined with intravenous urography and x-ray CT, definite length of ureteral stricture was obtained only with MR urography. In 5 patients with hydronephrotic transformation MR urography was much more informative than excretory urography. MR urography provided information sufficient for diagnosis. Sensitivity of MR urography and that with diuretic load was 86.8 and 92.3%, respectively. MR urography, even without contrast enhancement, provides images with high resolution sufficient for visualization of the ureter distally of the stricture and is a method of choice in patients with subnormal renal function, intolerance to iodine-containing contrast media, with hyperthyroidism and pregnant women after the first trimester.