1.
Chem Pharm Bull (Tokyo)
; 62(10): 956-61, 2014.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25273054
RESUMO
An asymmetric reductive aldol-type reaction of α,ß-unsaturated esters with carbonyl compounds using Rh catalyst and Et2Zn was investigated. A chiral zinc complex from α,ß-unsaturated ester was easily generated as the key intermediate from Et2Zn and Wilkinson's catalyst with diisopropyl L-(+)-tartrate to give a variety of enantioenriched ß-hydroxy esters. The reaction was also applied to the intramolecular reductive aldol cyclization.